College Football Predictions & CFB Simulator - MyGameSim.com

College Football Predictions for Week 6


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10/2/2025 NCAA FB Games
TimeMatchupPredictionActualResult
9 PM  Sam Houston @ New Mexico State  
by 2.5
New Mexico State
WIN 22.6-10.3
won 79.21% of sims, average margin of 12.3
Prediction
New Mexico State wins 37-10
 

 
10/3/2025 NCAA FB Games
TimeMatchupPredictionActualResult
7 PM  Western Kentucky @ Delaware  
by 1.5
Western Kentucky
WIN 31.3-21.2
won 71.56% of sims, average margin of 10.1
Prediction
Western Kentucky wins 27-24
 

 
7 PM  Charlotte @ USF  
by 28.5
USF
WIN 49.8-7.2
won 99.69% of sims, average margin of 42.6
Prediction
USF wins 54-26
 

10 PM  New Mexico @ San Jose State  
by 3.5
San Jose State
WIN 27.6-21.8
won 63.44% of sims, average margin of 5.8
Prediction
San Jose State wins 35-28
 

 
 
10:30 PM  West Virginia @ BYU (19) 
by 20.5
BYU
WIN 32.5-12.3
won 90.94% of sims, average margin of 20.2
Prediction
BYU wins 38-24
 

 
 
10:30 PM  Colorado State @ San Diego State  
by 5.5
Colorado State
WIN 12.9-12.2
won 52.19% of sims, average margin of 0.7
Prediction
San Diego State wins 45-24
 

10/4/2025 NCAA FB Games
TimeMatchupPredictionActualResult
12 PM  Wisconsin @ Michigan (5) 
by 16.5
Michigan
WIN 43.9-6.4
won 99.47% of sims, average margin of 37.4
Prediction
Michigan wins 24-10
 

12 PM  Iowa State @ Cincinnati (20) 
by 3.5
Cincinnati
WIN 42.1-16.8
won 96.05% of sims, average margin of 25.3
Prediction
Cincinnati wins 38-30
 

 
12 PM  Illinois @ Purdue  
by 7.5
Illinois
WIN 30.1-21.1
won 71.05% of sims, average margin of 8.9
Prediction
Illinois wins 43-27
 

 
12 PM  Kentucky @ Georgia  
by 20.5
Georgia
WIN 27.4-24.8
won 57.11% of sims, average margin of 2.6
Prediction
Georgia wins 35-14
 

12 PM  Air Force @ Navy  
by 11.5
Navy
WIN 33.4-32.9
won 49.21% of sims, average margin of 0.5
Prediction
Navy wins 34-31
 

 
 
12 PM  Kansas State @ Baylor  
by 5.5
Kansas State
WIN 26.5-20.3
won 67.89% of sims, average margin of 6.2
Prediction
Baylor wins 35-34
 

 
12 PM  Clemson @ UNC  
by 13.5
Clemson
WIN 33.0-10.1
won 93.16% of sims, average margin of 22.9
Prediction
Clemson wins 38-10
 

 
 
12 PM  Army @ UAB  
by 9.5
UAB
WIN 32.7-20.0
won 76.84% of sims, average margin of 12.7
Prediction
Army wins 31-13
 

12 PM  Ohio @ Ball State  
by 17.5
Ohio
WIN 32.2-15.8
won 86.58% of sims, average margin of 16.4
Prediction
Ball State wins 20-14
 

 
12 PM  Boston College @ Pittsburgh (10) 
by 4.5
Pittsburgh
WIN 31.2-24.0
won 66.32% of sims, average margin of 7.2
Prediction
Pittsburgh wins 48-7
 

 
1 PM  Wake Forest (14) @ Virginia Tech  
by 5.5
Virginia Tech
WIN 28.5-15.2
won 82.63% of sims, average margin of 13.3
Prediction
Wake Forest wins 30-23
 

1 PM  TX-San Antonio @ Temple  
by 6.5
TX-San Antonio
WIN 30.3-19.9
won 73.16% of sims, average margin of 10.5
Prediction
Temple wins 27-21
 

2 PM  Campbell @ NC State  
NC State
WIN 34.3-13.8
won 89.85% of sims, average margin of 20.4
Prediction
NC State wins 56-10
 

2:30 PM  Western Michigan @ Massachusetts  
by 10.5
Western Michigan
WIN 18.6-13.7
won 65.53% of sims, average margin of 4.9
Prediction
Western Michigan wins 21-3
 

3 PM  Oklahoma State @ Arizona  
by 17.5
Arizona
WIN 37.8-9.9
won 97.11% of sims, average margin of 27.9
Prediction
Arizona wins 41-13
 

 
 
3:30 PM  Vanderbilt (9) @ Alabama  
by 22.5
Alabama
WIN 30.1-27.5
won 59.06% of sims, average margin of 2.7
Prediction
Alabama wins 30-14
 

 
3:30 PM  Virginia @ Louisville (12) 
by 7.5
Louisville
WIN 34.1-28.9
won 61.84% of sims, average margin of 5.2
Prediction
Virginia wins 30-27
 

 
3:30 PM  Boise State (25) @ Notre Dame (2) 
by 16.5
Boise State
WIN 36.7-25.1
won 75.63% of sims, average margin of 11.7
Prediction
Notre Dame wins 28-7
 

3:30 PM  Washington (21) @ Maryland  
by 7.5
Washington
WIN 35.9-16.3
won 90.00% of sims, average margin of 19.6
Prediction
Washington wins 24-20
 

3:30 PM  James Madison @ Georgia State  
by 17.5
Georgia State
WIN 32.9-8.2
won 95.51% of sims, average margin of 24.7
Prediction
James Madison wins 14-7
 

 
3:30 PM  Texas (3) @ Florida  
by 6.5
Texas
WIN 18.9-18.2
won 54.06% of sims, average margin of 0.7
Prediction
Florida wins 29-21
 

 
3:30 PM  Syracuse @ SMU  
by 16.5
Syracuse
WIN 40.5-13.6
won 94.06% of sims, average margin of 26.9
Prediction
SMU wins 31-18
 

 
3:30 PM  UL Monroe @ Northwestern  
by 9.5
Northwestern
WIN 25.3-12.7
won 80.53% of sims, average margin of 12.6
Prediction
Northwestern wins 42-7
 

 
3:30 PM  Oregon State @ Appalachian State  
by 1.5
Oregon State
WIN 28.4-20.5
won 68.68% of sims, average margin of 7.9
Prediction
Appalachian State wins 27-23
 

3:30 PM  Penn State @ UCLA  
by 27.5
Penn State
WIN 25.0-19.7
won 64.06% of sims, average margin of 5.3
Prediction
UCLA wins 42-37
 

 
3:30 PM  FIU @ Connecticut  
by 10
Connecticut
WIN 46.0-10.5
won 99.38% of sims, average margin of 35.5
Prediction
Connecticut wins 51-10
 

 
 
3:30 PM  Miami (Ohio) @ Northern Illinois  
by 1.5
Miami (Ohio)
WIN 22.8-11.3
won 82.50% of sims, average margin of 11.4
Prediction
Miami (Ohio) wins 25-14
 

 
 
3:30 PM  Central Michigan @ Akron  
by 7
Central Michigan
WIN 24.4-12.5
won 83.44% of sims, average margin of 11.9
Prediction
Akron wins 28-22
 

3:30 PM  Eastern Michigan @ Buffalo  
by 9.5
Buffalo
WIN 22.1-19.0
won 57.81% of sims, average margin of 3.0
Prediction
Buffalo wins 31-30
 

 
 
4 PM  Kent State @ Oklahoma (17) 
by 45.5
Oklahoma
WIN 26.4-6.8
won 93.44% of sims, average margin of 19.5
Prediction
Oklahoma wins 44-0
 

 
4 PM  Michigan State @ Nebraska (15) 
by 10
Nebraska
WIN 35.0-16.2
won 91.25% of sims, average margin of 18.9
Prediction
Nebraska wins 38-27
 

 
4 PM  Texas State @ Arkansas State  
by 8.5
Texas State
WIN 29.8-21.0
won 71.56% of sims, average margin of 8.9
Prediction
Arkansas State wins 31-30
 

6 PM  Coastal Carolina @ Old Dominion  
by 15
Old Dominion
WIN 47.3-9.0
won 99.69% of sims, average margin of 38.3
Prediction
Old Dominion wins 47-7
 

 
 
7 PM  Texas Tech (11) @ Houston  
by 8.5
Texas Tech
WIN 30.3-17.8
won 83.44% of sims, average margin of 12.5
Prediction
Texas Tech wins 35-11
 

 
7 PM  Florida Atlantic @ Rice  
by 5.5
Rice
WIN 19.5-17.6
won 55.63% of sims, average margin of 1.8
Prediction
Florida Atlantic wins 27-21
 

 
7 PM  South Alabama @ Troy  
by 3
Troy
WIN 22.8-18.1
won 61.88% of sims, average margin of 4.7
Prediction
Troy wins 31-24
 

 
 
7 PM  UNLV @ Wyoming  
by 4.5
Wyoming
WIN 27.4-21.2
won 65.31% of sims, average margin of 6.2
Prediction
UNLV wins 31-17
 

7:30 PM  Mississippi State @ Texas A&M (1) 
by 13.5
Texas A&M
WIN 40.1-12.7
won 95.63% of sims, average margin of 27.4
Prediction
Texas A&M wins 31-9
 

 
 
7:30 PM  Miami (6) @ Florida State (8) 
by 7
Miami
WIN 30.8-29.9
won 52.50% of sims, average margin of 1.0
Prediction
Miami wins 28-22
 

 
 
7:30 PM  Minnesota @ Ohio State (4) 
by 21
Ohio State
WIN 46.8-11.0
won 99.38% of sims, average margin of 35.7
Prediction
Ohio State wins 42-3
 

 
 
7:30 PM  Colorado @ TCU  
by 13.5
Colorado
WIN 41.6-13.7
won 95.94% of sims, average margin of 27.9
Prediction
TCU wins 35-21
 

7:30 PM  Kansas (18) @ UCF  
by 3
Kansas
WIN 39.8-22.6
won 85.94% of sims, average margin of 17.2
Prediction
Kansas wins 27-20
 

 
8 PM  Tulsa @ Memphis  
by 21
Memphis
WIN 39.4-14.9
won 92.50% of sims, average margin of 24.5
Prediction
Memphis wins 45-7
 

 
10:30 PM  Duke @ California  
by 1.5
Duke
WIN 50.3-13.4
won 98.13% of sims, average margin of 37.0
Prediction
Duke wins 45-21
 

 
10:30 PM  Nevada @ Fresno State  
by 15.5
Fresno State
WIN 33.8-13.5
won 90.94% of sims, average margin of 20.2
Prediction
Fresno State wins 20-17
 

Legend/Totals

 TotalTop 25
Correct Picks 33 (64.7%)13 (76.5%)
Incorrect Picks 18 (35.3%)4 (23.5%)
Final Margin within 5 Pts 13 (25.5%)4 (23.5%)
Beat the Spread 34 (68.0%)13 (76.5%)

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