Prediction: Louisville vs SMU on 11/22/2025 | College Football Predictions - MyGameSim.com

College Football Prediction
Louisville vs SMU on 11/22/2025

See the simulated matchup results between the SMU and the Louisville powered by MyGameSim. Get predicted scores, projected player stats, and key insights from our College Football Game Simulator.

PREDICTED SCORE
Spread: SMU by 1.5 Over/Under: 53.5

The predicted score is SMU (2026): 21.8 - Louisville (2026): 34.6, decided by < 7 pts 68 times (21.3%)


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MATCHUP SIMULATION STATS
SMU vs. Louisville
 

(2026)

» SMU won 40 times (12.5%)

» SMU won by >20 pts 0 times (0.0%)

(2026)

» Louisville won 280 times (87.5%)

» Louisville won by >20 pts 90 times (28.1%)

 
PROJECTED PLAYER STATS
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Louisville Passing

PlayerATTCPYDSAVGTDINTLGRTG
Player 1 -- -- -- -- -- -- -- --

Louisville Rushing

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --

Louisville Receiving

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --
Player 5 -- -- -- -- --
Player 6 -- -- -- -- --

SMU Passing

PlayerATTCPYDSAVGTDINTLGRTG
Player 1 -- -- -- -- -- -- -- --

SMU Rushing

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --

SMU Receiving

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --
Player 5 -- -- -- -- --
Player 6 -- -- -- -- --

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