MLB Predictions & Baseball Game Simulator - MyGameSim.com

MLB Predictions for 9/28/2025


9/28/2025 MLB Games
Time *ETMatchupPredictionActualResult
3:05 PM Detroit Tigers @ Boston Red Sox  
Chris Paddack vs Jose De Leon
by 1.5
+/- Lineups
Boston Red Sox
WIN 4.7-4.1
  by 0.6
Prediction
Boston Red Sox wins 4-3

 
 
3:05 PM Kansas City Royals @ Athletics  
Cole Ragans vs Mitch Spence
by 1.5
+/- Lineups
Kansas City Royals
WIN 4.6-4.4
  by 0.2
Prediction
Kansas City Royals wins 9-2

3:05 PM Colorado Rockies @ San Francisco Giants  
McCade Brown vs Logan Webb
by 1.5
+/- Lineups
San Francisco Giants
WIN 4.6-3.7
  by 0.9
Prediction
San Francisco Giants wins 4-0

3:05 PM Minnesota Twins @ Philadelphia Phillies  
Simeon Woods Richardson vs Cristopher Sanchez
by 1.5
+/- Lineups
Philadelphia Phillies
WIN 4.7-3.5
  by 1.2
Prediction
Philadelphia Phillies wins 2-1

 
 
3:05 PM Chicago White Sox @ Washington Nationals  
Shane Smith vs Brad Lord
by 1.5
+/- Lineups
Chicago White Sox
WIN 4.4-3.5
  by 0.9
Prediction
Chicago White Sox wins 8-0

3:05 PM Baltimore Orioles @ New York Yankees  
Kyle Bradish vs Luis Gil
by 1.5
+/- Lineups
New York Yankees
WIN 5.2-4.9
  by 0.3
Prediction
New York Yankees wins 3-2

 
 
3:07 PM Houston Astros @ Los Angeles Angels  
Lance McCullers Jr. vs Sam Aldegheri
by 1.5
+/- Lineups
Houston Astros
WIN 5.6-4.4
  by 1.2
Prediction
Houston Astros wins 6-2

3:07 PM Tampa Bay Rays @ Toronto Blue Jays  
Ian Seymour vs Kevin Gausman
by 1.5
+/- Lineups
Toronto Blue Jays
WIN 3.7-3.4
  by 0.3
Prediction
Toronto Blue Jays wins 13-4

3:10 PM Texas Rangers @ Cleveland Guardians  
Patrick Corbin vs Logan Allen
by 1.5
+/- Lineups
Texas Rangers
WIN 3.7-3.3
  by 0.3
Prediction
Cleveland Guardians wins 9-8

 
3:10 PM Arizona Diamondbacks @ San Diego Padres  
Brandon Pfaadt vs JP Sears
by 1.5
+/- Lineups
San Diego Padres
WIN 4.5-3.9
  by 0.6
Prediction
San Diego Padres wins 12-4

3:10 PM Los Angeles Dodgers @ Seattle Mariners  
Clayton Kershaw vs Bryce Miller
by 1.5
+/- Lineups
Los Angeles Dodgers
WIN 4.8-4.2
  by 0.6
Prediction
Los Angeles Dodgers wins 6-1

3:10 PM New York Mets @ Miami Marlins  
Sean Manaea vs Edward Cabrera
by 1.5
+/- Lineups
New York Mets
WIN 4.9-3.9
  by 1.0
Prediction
Miami Marlins wins 4-0

 
3:10 PM Cincinnati Reds @ Milwaukee Brewers  
Brady Singer vs Freddy Peralta
by 1.5
+/- Lineups
Milwaukee Brewers
WIN 4.5-4.0
  by 0.6
Prediction
Milwaukee Brewers wins 4-2

3:15 PM Pittsburgh Pirates @ Atlanta Braves  
Johan Oviedo vs Chris Sale
by 1.5
+/- Lineups
Atlanta Braves
WIN 4.4-3.1
  by 1.2
Prediction
Atlanta Braves wins 4-1

3:20 PM St. Louis Cardinals @ Chicago Cubs  
Andre Pallante vs Javier Assad
by 1.5
+/- Lineups
Chicago Cubs
WIN 4.6-3.3
  by 1.3
Prediction
Chicago Cubs wins 2-0

 

Legend/Totals

Correct Picks 13 (86.7%)
Incorrect Picks 2 (13.3%)
Final Margin within 5 Runs 4 (26.7%)
Beat the Spread 5 (33.3%)

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