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Predictions refresh daily and may update during the day when key injuries or depth chart changes occur.

MLB Predictions for 9/5/2025

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Odds: Line | O/U | Money Line

9/5/2025 MLB Games
Time *ET	Matchup	Prediction	Actual	Result
2:20 PM	Washington Nationals @ Chicago Cubs Jake Irvin vs Javier Assad by 1.5 +/- Lineups James Wood LF CJ Abrams SS Josh Bell DH Daylen Lile RF Luis Garcia 2B Andres Chaparro 1B Riley Adams C Robert Hassell CF Brady House 3B Jake Irvin P Michael Busch 1B Ian Happ LF Seiya Suzuki DH Pete Crow-Armstrong CF Nico Hoerner 2B Willi Castro RF Dansby Swanson SS Matt Shaw 3B Reese McGuire C Javier Assad P	Chicago Cubs WIN 4.3-4.1 by 0.2 Prediction	Chicago Cubs wins 11-5
6:40 PM	Milwaukee Brewers @ Pittsburgh Pirates Quinn Priester vs Johan Oviedo by 1.5 +/- Lineups Brice Turang 2B Isaac Collins LF Jackson Chourio CF William Contreras C Sal Frelick RF Andrew Vaughn 1B Jake Bauers DH Caleb Durbin 3B Joey Ortiz SS Quinn Priester P Jared Triolo 3B Spencer Horwitz 1B Bryan Reynolds RF Tommy Pham LF Andrew McCutchen DH Nick Gonzales SS Oneil Cruz CF Joey Bart C Nick Yorke 2B Johan Oviedo P	Pittsburgh Pirates WIN 3.9-3.9 by 0.0 Prediction	Milwaukee Brewers wins 5-2
6:40 PM	New York Mets @ Cincinnati Reds David Peterson vs Andrew Abbott by 1.5 +/- Lineups Francisco Lindor SS Juan Soto RF Pete Alonso 1B Mark Vientos 3B Brandon Nimmo LF Starling Marte DH Jeff McNeil CF Francisco Alvarez C Luisangel Acuna 2B David Peterson P TJ Friedl CF Noelvi Marte RF Elly De La Cruz SS Miguel Andujar DH Austin Hays LF Spencer Steer 1B Tyler Stephenson C Ke'Bryan Hayes 3B Matt McLain 2B Andrew Abbott P	Cincinnati Reds WIN 4.8-4.6 by 0.2 Prediction	New York Mets wins 5-4
6:40 PM	Chicago White Sox @ Detroit Tigers Shane Smith vs Jack Flaherty by 1.5 +/- Lineups Edgar Quero DH Kyle Teel C Curtis Mead 1B Colson Montgomery SS Chase Meidroth 2B Andrew Benintendi LF Will Robertson RF Bryan Ramos 3B Dominic Fletcher CF Shane Smith P Colt Keith 3B Gleyber Torres 2B Kerry Carpenter DH Riley Greene LF Spencer Torkelson 1B Wenceel Perez RF Zach McKinstry SS Dillon Dingler C Parker Meadows CF Jack Flaherty P	Detroit Tigers WIN 5.0-4.6 by 0.4 Prediction	Chicago White Sox wins 7-5
7:05 PM	Los Angeles Dodgers @ Baltimore Orioles Shohei Ohtani vs Dean Kremer by 1.5 +/- Lineups Shohei Ohtani DH Mookie Betts SS Freddie Freeman 1B Teoscar Hernandez RF Michael Conforto LF Andy Pages CF Hyeseong Kim 2B Dalton Rushing C Miguel Rojas 3B Shohei Ohtani P Jackson Holliday 2B Jeremiah Jackson RF Gunnar Henderson SS Ryan Mountcastle DH Colton Cowser CF Emmanuel Rivera 3B Dylan Beavers LF Samuel Basallo C Coby Mayo 1B Dean Kremer P	Los Angeles Dodgers WIN 4.9-4.6 by 0.3 Prediction	Baltimore Orioles wins 2-1
7:05 PM	Toronto Blue Jays @ New York Yankees Kevin Gausman vs Cam Schlittler by 1.5 +/- Lineups George Springer DH Addison Barger RF Vladimir Guerrero 1B Bo Bichette SS Daulton Varsho CF Alejandro Kirk C Nathan Lukes LF Ernie Clement 3B Andres Gimenez 2B Kevin Gausman P Trent Grisham CF Ben Rice C Aaron Judge RF Cody Bellinger LF Giancarlo Stanton DH Jazz Chisholm 2B Paul Goldschmidt 1B Ryan McMahon 3B Jose Caballero SS Cam Schlittler P	New York Yankees WIN 5.6-5.2 by 0.4 Prediction	Toronto Blue Jays wins 7-1
7:10 PM	Philadelphia Phillies @ Miami Marlins Cristopher Sanchez vs Valente Bellozo by 1.5 +/- Lineups Trea Turner SS Kyle Schwarber DH Bryce Harper 1B J.T. Realmuto C Brandon Marsh LF Harrison Bader CF Max Kepler RF Alec Bohm 3B Bryson Stott 2B Cristopher Sanchez P Otto Lopez SS Agustin Ramirez C Jakob Marsee CF Heriberto Hernandez DH Eric Wagaman 1B Joey Wiemer RF Maximo Acosta 2B Victor Mesa LF Javier Sanoja 3B Valente Bellozo P	Philadelphia Phillies WIN 4.8-3.6 by 1.2 Prediction	Philadelphia Phillies wins 9-3
7:15 PM	Seattle Mariners @ Atlanta Braves Logan Gilbert vs Chris Sale by 1.5 +/- Lineups Randy Arozarena LF Cal Raleigh C Julio Rodriguez CF Eugenio Suarez 3B Jorge Polanco 2B Mitch Garver DH Dominic Canzone RF Leo Rivas SS Luke Raley 1B Logan Gilbert P Jurickson Profar LF Matt Olson 1B Ozzie Albies 2B Drake Baldwin C Ha-Seong Kim SS Michael Harris CF Marcell Ozuna DH Jake Fraley RF Nacho Alvarez 3B Chris Sale P	Seattle Mariners WIN 4.3-4.0 by 0.3 Prediction	Atlanta Braves wins 4-1
7:35 PM	Cleveland Guardians @ Tampa Bay Rays Gavin Williams vs Ian Seymour by 1.5 +/- Lineups Steven Kwan LF Angel Martinez CF Jose Ramirez 3B David Fry DH Nolan Jones RF Gabriel Arias SS Jhonkensy Noel 1B Brayan Rocchio 2B Austin Hedges C Gavin Williams P Richie Palacios LF Yandy Diaz DH Brandon Lowe 2B Junior Caminero 3B Josh Lowe RF Jake Mangum CF Hunter Feduccia C Carson Williams SS Bob Seymour 1B Ian Seymour P	Tampa Bay Rays WIN 4.2-3.0 by 1.3 Prediction	Cleveland Guardians wins 7-1
7:40 PM	Minnesota Twins @ Kansas City Royals Pablo Lopez vs Michael Wacha by 1.5 +/- Lineups Byron Buxton CF Trevor Larnach DH Luke Keaschall 2B Kody Clemens 1B Austin Martin LF Matt Wallner RF Royce Lewis 3B Brooks Lee SS Jhonny Pereda C Pablo Lopez P Mike Yastrzemski DH Bobby Witt SS Vinnie Pasquantino 1B Maikel Garcia 3B Salvador Perez C Adam Frazier LF Michael Massey 2B Jac Caglianone RF Kyle Isbel CF Michael Wacha P	Kansas City Royals WIN 4.3-4.2 by 0.0 Prediction	Kansas City Royals wins 2-1
8:05 PM	Houston Astros @ Texas Rangers Colton Gordon vs Merrill Kelly by 1.5 +/- Lineups Jeremy Pena SS Yordan Alvarez DH Jose Altuve 2B Carlos Correa 3B Jesus Sanchez LF Christian Walker 1B Victor Caratini C Taylor Trammell CF Cam Smith RF Colton Gordon P Michael Helman CF Cody Freeman 2B Wyatt Langford LF Jake Burger 1B Kyle Higashioka C Josh Jung 3B Ezequiel Duran RF Dylan Moore DH Josh Smith SS Merrill Kelly P	Texas Rangers WIN 4.3-3.6 by 0.7 Prediction	Texas Rangers wins 4-3
8:15 PM	San Francisco Giants @ St. Louis Cardinals Carson Seymour vs Michael McGreevy by 1.5 +/- Lineups Heliot Ramos LF Rafael Devers DH Willy Adames SS Dominic Smith 1B Matt Chapman 3B Jung Hoo Lee CF Casey Schmitt 2B Drew Gilbert RF Patrick Bailey C Carson Seymour P Lars Nootbaar LF Ivan Herrera DH Nolan Gorman 1B Masyn Winn SS Jimmy Crooks C Thomas Saggese 3B Jordan Walker RF Victor Scott CF Jose Fermin 2B Michael McGreevy P	St. Louis Cardinals WIN 4.1-3.8 by 0.3 Prediction	San Francisco Giants wins 8-2
8:40 PM	San Diego Padres @ Colorado Rockies Nick Pivetta vs Kyle Freeland by 1.5 +/- Lineups Fernando Tatis RF Ryan O'Hearn 1B Manny Machado 3B Gavin Sheets DH Ramon Laureano LF Jackson Merrill CF Jose Iglesias SS Jake Cronenworth 2B Elias Diaz C Nick Pivetta P Tyler Freeman DH Mickey Moniak RF Hunter Goodman C Jordan Beck LF Brenton Doyle CF Ezequiel Tovar SS Kyle Karros 3B Warming Bernabel 1B Ryan Ritter 2B Kyle Freeland P	San Diego Padres WIN 4.9-3.3 by 1.6 Prediction	Colorado Rockies wins 3-0
9:38 PM	Athletics @ Los Angeles Angels Mason Barnett vs Jose Soriano by 1.5 +/- Lineups Nick Kurtz 1B Shea Langeliers C Brent Rooker DH Tyler Soderstrom LF Jacob Wilson SS Lawrence Butler CF Zack Gelof 2B JJ Bleday RF Darell Hernaiz 3B Mason Barnett P Zach Neto SS Mike Trout DH Yoan Moncada 3B Taylor Ward LF Jo Adell RF Luis Rengifo 2B Oswald Peraza 1B Travis d'Arnaud C Bryce Teodosio CF Jose Soriano P	Athletics WIN 4.5-4.4 by 0.1 Prediction	Athletics wins 10-4
9:40 PM	Boston Red Sox @ Arizona Diamondbacks Payton Tolle vs Eduardo Rodriguez by 1.5 +/- Lineups Jarren Duran LF Alex Bregman 3B Trevor Story SS Romy Gonzalez 2B Rob Refsnyder DH Nathaniel Lowe 1B Nate Eaton RF Ceddanne Rafaela CF Carlos Narvaez C Payton Tolle P Ketel Marte 2B Geraldo Perdomo SS Corbin Carroll RF Gabriel Moreno C Blaze Alexander CF Ildemaro Vargas DH Jordan Lawlar 3B Tyler Locklear 1B Jorge Barrosa LF Eduardo Rodriguez P	Boston Red Sox WIN 5.5-2.7 by 2.7 Prediction	Arizona Diamondbacks wins 10-5

Legend/Totals

Correct Picks	5 (33.3%)
Incorrect Picks	10 (66.7%)
Final Margin within 5 Runs	2 (13.3%)
Beat the Spread	8 (53.3%)

MLB Predictions for 9/5/2025

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