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Predictions refresh daily and may update during the day when key injuries or depth chart changes occur.

MLB Predictions for 9/27/2025

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Odds: Line | O/U | Money Line

9/27/2025 MLB Games
Time *ET	Matchup	Prediction	Actual	Result
1:05 PM	Baltimore Orioles @ New York Yankees Tomoyuki Sugano vs Cam Schlittler by 1.5 +/- Lineups Jackson Holliday 2B Jordan Westburg 3B Gunnar Henderson SS Tyler O'Neill DH Dylan Beavers LF Jeremiah Jackson RF Colton Cowser CF Samuel Basallo C Coby Mayo 1B Tomoyuki Sugano P Trent Grisham CF Ben Rice C Aaron Judge RF Cody Bellinger LF Giancarlo Stanton DH Jazz Chisholm 2B Paul Goldschmidt 1B Ryan McMahon 3B Anthony Volpe SS Cam Schlittler P	New York Yankees WIN 5.7-4.4 by 1.2 Prediction	New York Yankees wins 6-1
2:20 PM	St. Louis Cardinals @ Chicago Cubs Michael McGreevy vs Jameson Taillon by 1.5 +/- Lineups Lars Nootbaar LF Ivan Herrera DH Alec Burleson 1B Nolan Arenado 3B Nolan Gorman 2B Thomas Saggese SS Jimmy Crooks C Jordan Walker RF Victor Scott CF Michael McGreevy P Michael Busch 1B Nico Hoerner 2B Ian Happ LF Kyle Tucker DH Seiya Suzuki RF Carson Kelly C Pete Crow-Armstrong CF Dansby Swanson SS Matt Shaw 3B Jameson Taillon P	Chicago Cubs WIN 5.4-3.8 by 1.6 Prediction	Chicago Cubs wins 7-3
3:07 PM	Tampa Bay Rays @ Toronto Blue Jays Joe Boyle vs Trey Yesavage by 1.5 +/- Lineups Chandler Simpson CF Yandy Diaz DH Brandon Lowe 2B Junior Caminero 3B Jonathan Aranda 1B Christopher Morel LF Jake Mangum RF Nick Fortes C Carson Williams SS Joe Boyle P George Springer DH Nathan Lukes RF Vladimir Guerrero 1B Addison Barger 3B Davis Schneider LF Daulton Varsho CF Alejandro Kirk C Ernie Clement 2B Andres Gimenez SS Trey Yesavage P	Toronto Blue Jays WIN 4.6-4.2 by 0.4 Prediction	Toronto Blue Jays wins 5-1
4:05 PM	Colorado Rockies @ San Francisco Giants Kyle Freeland vs Justin Verlander by 1.5 +/- Lineups Ezequiel Tovar SS Hunter Goodman C Blaine Crim 1B Jordan Beck LF Brenton Doyle CF Yanquiel Fernandez RF Kyle Karros 3B Warming Bernabel DH Ryan Ritter 2B Kyle Freeland P Heliot Ramos LF Rafael Devers 1B Willy Adames SS Matt Chapman 3B Wilmer Flores DH Casey Schmitt 2B Jung Hoo Lee CF Jerar Encarnacion RF Andrew Knizner C Justin Verlander P	Colorado Rockies WIN 4.6-4.5 by 0.1 Prediction	San Francisco Giants wins 4-3
4:05 PM	Chicago White Sox @ Washington Nationals Sean Burke vs Jake Irvin by 1.5 +/- Lineups Chase Meidroth 2B Kyle Teel C Colson Montgomery SS Miguel Vargas 3B Edgar Quero DH Brooks Baldwin LF Lenyn Sosa 1B Dominic Fletcher RF Derek Hill CF Sean Burke P James Wood LF CJ Abrams SS Josh Bell DH Daylen Lile RF Jorge Alfaro C Luis Garcia 1B Brady House 3B Nasim Nunez 2B Jacob Young CF Jake Irvin P	Chicago White Sox WIN 4.5-3.8 by 0.6 Prediction	Washington Nationals wins 6-5
4:10 PM	Detroit Tigers @ Boston Red Sox Keider Montero vs Connelly Early by 1.5 +/- Lineups Jahmai Jones DH Gleyber Torres 2B Wenceel Perez RF Spencer Torkelson 1B Riley Greene LF Dillon Dingler C Andy Ibanez 3B Javier Baez SS Parker Meadows CF Keider Montero P David Hamilton SS Wilyer Abreu RF Rob Refsnyder DH Masataka Yoshida LF Ceddanne Rafaela CF Nathaniel Lowe 1B Carlos Narvaez C Nate Eaton 3B Nick Sogard 2B Connelly Early P	Detroit Tigers WIN 4.7-4.4 by 0.3 Prediction	Detroit Tigers wins 2-1
4:10 PM	New York Mets @ Miami Marlins Clay Holmes vs Eury Perez by 1.5 +/- Lineups Francisco Lindor SS Juan Soto RF Pete Alonso 1B Brandon Nimmo LF Starling Marte DH Jeff McNeil 2B Francisco Alvarez C Ronny Mauricio 3B Tyrone Taylor CF Clay Holmes P Xavier Edwards 2B Jakob Marsee CF Connor Norby 3B Liam Hicks C Troy Johnston DH Griffin Conine RF Otto Lopez SS Graham Pauley 1B Heriberto Hernandez LF Eury Perez P	New York Mets WIN 4.6-4.1 by 0.5 Prediction	New York Mets wins 5-0
6:05 PM	Minnesota Twins @ Philadelphia Phillies Mick Abel vs Ranger Suarez by 1.5 +/- Lineups Byron Buxton DH Austin Martin LF Ryan Jeffers C Royce Lewis 3B Kody Clemens 1B Brooks Lee SS Carson McCusker RF Ryan Fitzgerald 2B James Outman CF Mick Abel P Harrison Bader CF Kyle Schwarber DH Bryce Harper 1B Alec Bohm 3B Brandon Marsh LF J.T. Realmuto C Nick Castellanos RF Bryson Stott 2B Edmundo Sosa SS Ranger Suarez P	Philadelphia Phillies WIN 6.6-4.2 by 2.3 Prediction	Minnesota Twins wins 5-0
7:15 PM	Texas Rangers @ Cleveland Guardians Jacob Latz vs Joey Cantillo by 1.5 +/- Lineups Michael Helman CF Cody Freeman LF Josh Jung 3B Adolis Garcia DH Kyle Higashioka C Jake Burger 1B Donovan Solano 2B Ezequiel Duran SS Dylan Moore RF Jacob Latz P Steven Kwan LF Angel Martinez CF Jose Ramirez 3B Johnathan Rodriguez RF Kyle Manzardo DH Gabriel Arias SS Jhonkensy Noel 1B Brayan Rocchio 2B Austin Hedges C Joey Cantillo P	Texas Rangers WIN 3.3-3.2 by 0.1 Prediction	Cleveland Guardians wins 3-2
7:15 PM	Pittsburgh Pirates @ Atlanta Braves Bubba Chandler vs Spencer Strider by 1.5 +/- Lineups Oneil Cruz CF Jared Triolo 3B Bryan Reynolds RF Spencer Horwitz 2B Nick Gonzales SS Joey Bart DH Jack Suwinski LF Rafael Flores 1B Henry Davis C Bubba Chandler P Jurickson Profar LF Matt Olson 1B Ronald Acuna RF Drake Baldwin C Ha-Seong Kim SS Michael Harris CF Marcell Ozuna DH Nacho Alvarez 3B Brett Wisely 2B Spencer Strider P	Atlanta Braves WIN 4.3-3.8 by 0.4 Prediction	Pittsburgh Pirates wins 3-1
7:15 PM	Cincinnati Reds @ Milwaukee Brewers Andrew Abbott vs Jacob Misiorowski by 1.5 +/- Lineups TJ Friedl CF Noelvi Marte RF Miguel Andujar DH Spencer Steer LF Sal Stewart 1B Elly De La Cruz SS Tyler Stephenson C Ke'Bryan Hayes 3B Matt McLain 2B Andrew Abbott P Christian Yelich DH Jackson Chourio RF Brice Turang 2B Andrew Vaughn 1B Isaac Collins LF Caleb Durbin 3B Blake Perkins CF Danny Jansen C Joey Ortiz SS Jacob Misiorowski P	Cincinnati Reds WIN 4.4-4.3 by 0.1 Prediction	Cincinnati Reds wins 7-4
8:40 PM	Arizona Diamondbacks @ San Diego Padres Eduardo Rodriguez vs Michael King by 1.5 +/- Lineups Geraldo Perdomo SS Gabriel Moreno C Adrian Del Castillo DH Blaze Alexander 3B Alek Thomas CF Ildemaro Vargas 1B Jake McCarthy LF Jorge Barrosa RF Connor Kaiser 2B Eduardo Rodriguez P Fernando Tatis RF Luis Arraez DH Xander Bogaerts SS Jackson Merrill CF Gavin Sheets LF Jose Iglesias 3B Ryan O'Hearn 1B Jake Cronenworth 2B Elias Diaz C Michael King P	San Diego Padres WIN 4.2-3.5 by 0.7 Prediction	San Diego Padres wins 5-1
9:38 PM	Houston Astros @ Los Angeles Angels AJ Blubaugh vs Caden Dana by 1.5 +/- Lineups Jose Altuve 2B Isaac Paredes DH Carlos Correa 3B Christian Walker 1B Yainer Diaz C Zach Cole CF Jesus Sanchez RF Mauricio Dubon SS Taylor Trammell LF AJ Blubaugh P Luis Rengifo 3B Mike Trout DH Taylor Ward LF Jo Adell RF Logan O'Hoppe C Christian Moore 2B Oswald Peraza 1B Denzer Guzman SS Bryce Teodosio CF Caden Dana P	Houston Astros WIN 5.1-3.3 by 1.8 Prediction	Houston Astros wins 6-1
9:40 PM	Los Angeles Dodgers @ Seattle Mariners Tyler Glasnow vs Logan Gilbert by 1.5 +/- Lineups Tommy Edman DH Mookie Betts SS Freddie Freeman 1B Andy Pages CF Michael Conforto LF Alex Call RF Miguel Rojas 2B Enrique Hernandez 3B Dalton Rushing C Tyler Glasnow P Randy Arozarena LF Cal Raleigh DH Julio Rodriguez CF Jorge Polanco 2B Eugenio Suarez 3B Dominic Canzone RF Luke Raley 1B Leo Rivas SS Harry Ford C Logan Gilbert P	Seattle Mariners WIN 4.2-3.3 by 0.8 Prediction	Los Angeles Dodgers wins 5-3
10:05 PM	Kansas City Royals @ Athletics Michael Wacha vs Luis Morales Even +/- Lineups Mike Yastrzemski RF Bobby Witt SS Vinnie Pasquantino 1B Maikel Garcia 3B Salvador Perez C Carter Jensen DH Adam Frazier LF Michael Massey 2B John Rave CF Michael Wacha P Nick Kurtz 1B Shea Langeliers C Tyler Soderstrom LF Brent Rooker DH Jacob Wilson SS Lawrence Butler CF Darell Hernaiz 3B Carlos Cortes RF Max Schuemann 2B Luis Morales P	Athletics WIN 4.5-3.8 by 0.6 Prediction	Kansas City Royals wins 4-2

Legend/Totals

Correct Picks	8 (53.3%)
Incorrect Picks	7 (46.7%)
Final Margin within 5 Runs	1 (6.7%)
Beat the Spread	9 (60.0%)

MLB Predictions for 9/27/2025

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