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Predictions refresh daily and may update during the day when key injuries or depth chart changes occur.

MLB Predictions for 9/26/2025

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Odds: Line | O/U | Money Line

9/26/2025 MLB Games
Time *ET	Matchup	Prediction	Actual	Result
2:20 PM	St. Louis Cardinals @ Chicago Cubs Miles Mikolas vs Colin Rea O/U 9 +/- Lineups Lars Nootbaar LF Ivan Herrera DH Alec Burleson 1B Nolan Arenado 3B Nolan Gorman 2B Thomas Saggese SS Pedro Pages C Jordan Walker RF Victor Scott CF Miles Mikolas P Michael Busch 1B Nico Hoerner 2B Ian Happ LF Kyle Tucker DH Seiya Suzuki RF Pete Crow-Armstrong CF Dansby Swanson SS Reese McGuire C Matt Shaw 3B Colin Rea P	Chicago Cubs WIN 5.2-3.9 by 1.3 Prediction	Chicago Cubs wins 12-1
6:45 PM	Minnesota Twins @ Philadelphia Phillies Joe Ryan vs Aaron Nola O/U 8.5 +/- Lineups Byron Buxton CF Kody Clemens 2B Ryan Jeffers DH Trevor Larnach RF Brooks Lee SS Edouard Julien 1B Royce Lewis 3B James Outman LF Christian Vazquez C Joe Ryan P Harrison Bader CF Kyle Schwarber DH Bryce Harper 1B Alec Bohm 3B Brandon Marsh LF J.T. Realmuto C Nick Castellanos RF Bryson Stott 2B Edmundo Sosa SS Aaron Nola P	Philadelphia Phillies WIN 4.4-4.2 by 0.1 Prediction	Philadelphia Phillies wins 3-1
6:45 PM	Chicago White Sox @ Washington Nationals Yoendrys Gomez vs Cade Cavalli O/U 9 +/- Lineups Chase Meidroth 2B Kyle Teel DH Colson Montgomery SS Miguel Vargas 3B Edgar Quero C Brooks Baldwin CF Lenyn Sosa 1B Will Robertson LF Dominic Fletcher RF Yoendrys Gomez P James Wood LF CJ Abrams SS Josh Bell 1B Daylen Lile DH Dylan Crews RF Luis Garcia 2B Riley Adams C Robert Hassell CF Paul DeJong 3B Cade Cavalli P	Chicago White Sox WIN 4.2-3.8 by 0.4 Prediction	Chicago White Sox wins 10-9
7:05 PM	Baltimore Orioles @ New York Yankees Trevor Rogers vs Will Warren O/U 8.5 +/- Lineups Jackson Holliday 2B Jordan Westburg 3B Gunnar Henderson SS Tyler O'Neill RF Dylan Beavers LF Adley Rutschman C Colton Cowser CF Samuel Basallo DH Coby Mayo 1B Trevor Rogers P Paul Goldschmidt 1B Aaron Judge RF Cody Bellinger CF Giancarlo Stanton DH Amed Rosario 3B Austin Slater LF Anthony Volpe SS Austin Wells C Jose Caballero 2B Will Warren P	New York Yankees WIN 4.7-4.4 by 0.3 Prediction	New York Yankees wins 8-4
7:07 PM	Tampa Bay Rays @ Toronto Blue Jays Adrian Houser vs Shane Bieber O/U 8 +/- Lineups Chandler Simpson CF Yandy Diaz DH Brandon Lowe 2B Junior Caminero 3B Jonathan Aranda 1B Jake Mangum LF Josh Lowe RF Carson Williams SS Hunter Feduccia C Adrian Houser P George Springer DH Nathan Lukes RF Vladimir Guerrero 1B Addison Barger 3B Alejandro Kirk C Daulton Varsho CF Anthony Santander LF Ernie Clement 2B Andres Gimenez SS Shane Bieber P	Toronto Blue Jays WIN 4.8-3.7 by 1.2 Prediction	Toronto Blue Jays wins 4-2
7:10 PM	Detroit Tigers @ Boston Red Sox Casey Mize vs Kyle Harrison O/U 9 +/- Lineups Jahmai Jones DH Gleyber Torres 2B Wenceel Perez RF Spencer Torkelson 1B Riley Greene LF Andy Ibanez 3B Dillon Dingler C Parker Meadows CF Javier Baez SS Casey Mize P Jarren Duran LF Trevor Story SS Alex Bregman 3B Masataka Yoshida DH Romy Gonzalez 2B Ceddanne Rafaela CF Nathaniel Lowe 1B Wilyer Abreu RF Carlos Narvaez C Kyle Harrison P	Boston Red Sox WIN 4.7-4.5 by 0.2 Prediction	Boston Red Sox wins 4-3
7:10 PM	Texas Rangers @ Cleveland Guardians Jack Leiter vs Slade Cecconi O/U 7.5 +/- Lineups Joc Pederson DH Cody Freeman 2B Josh Jung 3B Rowdy Tellez 1B Ezequiel Duran SS Alejandro Osuna LF Jonah Heim C Billy McKinney RF Michael Helman CF Jack Leiter P Steven Kwan LF George Valera RF Jose Ramirez 3B Kyle Manzardo DH Bo Naylor C Gabriel Arias SS Daniel Schneemann CF C.J. Kayfus 1B Brayan Rocchio 2B Slade Cecconi P	Cleveland Guardians WIN 4.3-3.4 by 0.9 Prediction	Texas Rangers wins 7-3
7:10 PM	New York Mets @ Miami Marlins Brandon Sproat vs Sandy Alcantara O/U 8.5 +/- Lineups Francisco Lindor SS Juan Soto RF Brandon Nimmo LF Pete Alonso 1B Jeff McNeil 2B Brett Baty 3B Francisco Alvarez DH Cedric Mullins CF Luis Torrens C Brandon Sproat P Jakob Marsee CF Agustin Ramirez C Xavier Edwards 2B Liam Hicks DH Otto Lopez SS Griffin Conine RF Troy Johnston 1B Heriberto Hernandez LF Graham Pauley 3B Sandy Alcantara P	New York Mets WIN 4.7-4.0 by 0.7 Prediction	Miami Marlins wins 6-2
7:15 PM	Pittsburgh Pirates @ Atlanta Braves Mitch Keller vs Joey Wentz O/U 8.5 +/- Lineups Jared Triolo 3B Nick Gonzales SS Bryan Reynolds RF Andrew McCutchen DH Spencer Horwitz 1B Tommy Pham LF Alexander Canario CF Nick Yorke 2B Henry Davis C Mitch Keller P Jurickson Profar LF Matt Olson 1B Ronald Acuna RF Drake Baldwin C Ha-Seong Kim SS Michael Harris CF Marcell Ozuna DH Nacho Alvarez 3B Brett Wisely 2B Joey Wentz P	Atlanta Braves WIN 4.5-3.8 by 0.7 Prediction	Pittsburgh Pirates wins 9-3
8:10 PM	Cincinnati Reds @ Milwaukee Brewers Zack Littell vs Quinn Priester O/U 8 +/- Lineups TJ Friedl CF Noelvi Marte RF Gavin Lux LF Miguel Andujar DH Elly De La Cruz SS Spencer Steer 1B Tyler Stephenson C Ke'Bryan Hayes 3B Matt McLain 2B Zack Littell P Christian Yelich DH Jackson Chourio CF Brice Turang 2B William Contreras C Sal Frelick RF Andrew Vaughn 1B Jake Bauers LF Andruw Monasterio 3B Joey Ortiz SS Quinn Priester P	Cincinnati Reds WIN 4.5-4.2 by 0.3 Prediction	Cincinnati Reds wins 3-1
9:38 PM	Houston Astros @ Los Angeles Angels Jason Alexander vs Kyle Hendricks O/U 9 +/- Lineups Jose Altuve 2B Isaac Paredes DH Carlos Correa SS Christian Walker 1B Yainer Diaz C Jake Meyers CF Zach Cole RF Ramon Urias 3B Mauricio Dubon LF Jason Alexander P Nolan Schanuel 1B Mike Trout DH Taylor Ward LF Jo Adell RF Luis Rengifo 3B Logan O'Hoppe C Christian Moore 2B Denzer Guzman SS Bryce Teodosio CF Kyle Hendricks P	Houston Astros WIN 4.5-4.2 by 0.3 Prediction	Los Angeles Angels wins 4-3
9:40 PM	Arizona Diamondbacks @ San Diego Padres Zac Gallen vs Yu Darvish O/U 8 +/- Lineups Geraldo Perdomo SS Ketel Marte 2B Corbin Carroll RF Gabriel Moreno DH Blaze Alexander 3B James McCann C Alek Thomas CF Ildemaro Vargas 1B Jake McCarthy LF Zac Gallen P Fernando Tatis RF Luis Arraez 1B Manny Machado 3B Jackson Merrill CF Xander Bogaerts SS Gavin Sheets LF Ryan O'Hearn DH Jake Cronenworth 2B Freddy Fermin C Yu Darvish P	Arizona Diamondbacks WIN 4.6-4.4 by 0.2 Prediction	San Diego Padres wins 7-4
9:40 PM	Los Angeles Dodgers @ Seattle Mariners Emmet Sheehan vs George Kirby O/U 7 +/- Lineups Shohei Ohtani DH Andy Pages CF Michael Conforto LF Teoscar Hernandez RF Hyeseong Kim SS Miguel Rojas 2B Dalton Rushing 1B Enrique Hernandez 3B Ben Rortvedt C Emmet Sheehan P Randy Arozarena LF Cal Raleigh C Julio Rodriguez CF Josh Naylor DH Eugenio Suarez 3B Luke Raley 1B Victor Robles RF J.P. Crawford SS Cole Young 2B George Kirby P	Los Angeles Dodgers WIN 4.1-3.7 by 0.4 Prediction	Los Angeles Dodgers wins 3-2
10:05 PM	Kansas City Royals @ Athletics Noah Cameron vs Mason Barnett O/U 10 +/- Lineups Mike Yastrzemski CF Bobby Witt SS Vinnie Pasquantino 1B Maikel Garcia 3B Salvador Perez DH Carter Jensen C Jonathan India 2B Adam Frazier LF Jac Caglianone RF Noah Cameron P Shea Langeliers C Nick Kurtz 1B Brent Rooker DH Tyler Soderstrom LF Jacob Wilson SS Colby Thomas RF Lawrence Butler CF Darell Hernaiz 2B Brett Harris 3B Mason Barnett P	Kansas City Royals WIN 5.6-5.1 by 0.6 Prediction	Athletics wins 4-3
10:15 PM	Colorado Rockies @ San Francisco Giants German Marquez vs Trevor McDonald O/U 8.5 +/- Lineups Ezequiel Tovar SS Hunter Goodman DH Blaine Crim 1B Jordan Beck LF Yanquiel Fernandez RF Brenton Doyle CF Kyle Karros 3B Braxton Fulford C Ryan Ritter 2B German Marquez P Heliot Ramos LF Rafael Devers DH Willy Adames SS Matt Chapman 3B Bryce Eldridge 1B Casey Schmitt 2B Jung Hoo Lee CF Patrick Bailey C Grant McCray RF Trevor McDonald P	San Francisco Giants WIN 5.3-3.7 by 1.6 Prediction	San Francisco Giants wins 6-3

Legend/Totals

Correct Picks	9 (60.0%)
Incorrect Picks	6 (40.0%)
Final Margin within 5 Runs	4 (26.7%)
Beat the Spread	6 (40.0%)

MLB Predictions for 9/26/2025

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