MLB Predictions & Baseball Game Simulator - MyGameSim.com

MLB Predictions for 9/27/2025


9/27/2025 MLB Games
Time *ETMatchupPredictionActualResult
1:05 PM Baltimore Orioles @ New York Yankees  
Tomoyuki Sugano vs Cam Schlittler
-235 or 70.1%
+/- Lineups
New York Yankees
WIN 65.1% of sims
  by 1.2
Prediction
New York Yankees wins 6-1

2:20 PM St. Louis Cardinals @ Chicago Cubs  
Michael McGreevy vs Jameson Taillon
-178 or 64.0%
+/- Lineups
Chicago Cubs
WIN 68.5% of sims
  by 1.6
Prediction
Chicago Cubs wins 7-3

 
3:07 PM Tampa Bay Rays @ Toronto Blue Jays  
Joe Boyle vs Trey Yesavage
-172 or 63.2%
+/- Lineups
Toronto Blue Jays
WIN 57.6% of sims
  by 0.4
Prediction
Toronto Blue Jays wins 5-1

4:05 PM Colorado Rockies @ San Francisco Giants  
Kyle Freeland vs Justin Verlander
-240 or 70.6%
+/- Lineups
San Francisco Giants
WIN 53.3% of sims
  by 0.1
Prediction
San Francisco Giants wins 4-3

4:05 PM Chicago White Sox @ Washington Nationals  
Sean Burke vs Jake Irvin
-113 or 53.1%
+/- Lineups
Chicago White Sox
WIN 51.4% of sims
  by 0.6
Prediction
Washington Nationals wins 6-5

4:10 PM Detroit Tigers @ Boston Red Sox  
Keider Montero vs Connelly Early
-120 or 54.5%
+/- Lineups
Detroit Tigers
WIN 51.1% of sims
  by 0.3
Prediction
Detroit Tigers wins 2-1

 
 
4:10 PM New York Mets @ Miami Marlins  
Clay Holmes vs Eury Perez
-120 or 54.5%
+/- Lineups
New York Mets
WIN 52.0% of sims
  by 0.5
Prediction
New York Mets wins 5-0

6:05 PM Minnesota Twins @ Philadelphia Phillies  
Mick Abel vs Ranger Suarez
-246 or 71.1%
+/- Lineups
Philadelphia Phillies
WIN 70.6% of sims
  by 2.3
Prediction
Minnesota Twins wins 5-0

 
7:15 PM Texas Rangers @ Cleveland Guardians  
Jacob Latz vs Joey Cantillo
-154 or 60.6%
+/- Lineups
Texas Rangers
WIN 51.1% of sims
  by 0.1
Prediction
Cleveland Guardians wins 3-2

7:15 PM Pittsburgh Pirates @ Atlanta Braves  
Bubba Chandler vs Spencer Strider
-177 or 63.9%
+/- Lineups
Atlanta Braves
WIN 57.5% of sims
  by 0.4
Prediction
Pittsburgh Pirates wins 3-1

 
7:15 PM Cincinnati Reds @ Milwaukee Brewers  
Andrew Abbott vs Jacob Misiorowski
-126 or 55.8%
+/- Lineups
Milwaukee Brewers
WIN 51.9% of sims
  by 0.1
Prediction
Cincinnati Reds wins 7-4

 
8:40 PM Arizona Diamondbacks @ San Diego Padres  
Eduardo Rodriguez vs Michael King
-162 or 61.8%
+/- Lineups
San Diego Padres
WIN 59.8% of sims
  by 0.7
Prediction
San Diego Padres wins 5-1

9:38 PM Houston Astros @ Los Angeles Angels  
AJ Blubaugh vs Caden Dana
-120 or 54.5%
+/- Lineups
Houston Astros
WIN 63.6% of sims
  by 1.8
Prediction
Houston Astros wins 6-1

 
9:40 PM Los Angeles Dodgers @ Seattle Mariners  
Tyler Glasnow vs Logan Gilbert
-135 or 57.4%
+/- Lineups
Seattle Mariners
WIN 61.8% of sims
  by 0.8
Prediction
Los Angeles Dodgers wins 5-3

10:05 PM Kansas City Royals @ Athletics  
Michael Wacha vs Luis Morales
-120 or 54.5%
+/- Lineups
Athletics
WIN 59.5% of sims
  by 0.6
Prediction
Kansas City Royals wins 4-2

Legend/Totals

Correct Picks 8 (53.3%)
Incorrect Picks 7 (46.7%)
Final Margin within 5 Runs 1 (6.7%)
Beat the Spread 6 (40.0%)

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