NFL Prediction
Arizona Cardinals vs San Francisco 49ers on 9/21/2025
See the simulated matchup results between the 49ers and the Cardinals powered by MyGameSim. Get predicted scores, projected player stats, and key insights from our NFL Game Simulator.
FINAL SCORE
Spread: San Francisco 49ers by 2.5 Over/Under: 45.5
Prediction Accuracy
| Winner: | Incorrect |
| vs Spread: | Correct |
| Over/Under: | Correct |
The predicted score is 49ers (2026): 12.0 - Cardinals (2026): 15.0, decided by < 7 pts 277 times (30.7%)
📊 Simulation Breakdown
49ers (2026) 🏆 Won 365 times (40.5%)
💪 Blowout wins (>20 pts): 23 (2.5%)
Cardinals (2026) 🏆 Won 537 times (59.5%)
💪 Blowout wins (>20 pts): 66 (7.3%)
⏳ Overtime
57 (6.3%)
🎯 Close Game (<7 pts)
277 (30.7%)
💻 Total Simulations
902
Latest Lines
Spread
San Francisco 49ers -2.5 N/A | Arizona Cardinals +2.5 N/A
Total (O/U 45.5)
Over N/A | Under N/A
Insights ⓘ GOLD
Moneyline Edge:
Team +X.X% ⚡ Good Edge
Spread Cover:
Team covers XX% of sims ⚡
Over/Under:
XX% Over 🔥
📋 Projected Player Stats
Only Game Sim+ subscribers have access to view Projected Stats 
Cardinals Passing
| Player | ATT | CP | YDS | AVG | TD | INT | LG | RTG |
|---|---|---|---|---|---|---|---|---|
| Player 1 | -- | -- | -- | -- | -- | -- | -- | -- |
Cardinals Rushing
| Player | ATT | YDS | AVG | LG | TD |
|---|---|---|---|---|---|
| Player 1 | -- | -- | -- | -- | -- |
| Player 2 | -- | -- | -- | -- | -- |
| Player 3 | -- | -- | -- | -- | -- |
| Player 4 | -- | -- | -- | -- | -- |
Cardinals Receiving
| Player | ATT | YDS | AVG | LG | TD |
|---|---|---|---|---|---|
| Player 1 | -- | -- | -- | -- | -- |
| Player 2 | -- | -- | -- | -- | -- |
| Player 3 | -- | -- | -- | -- | -- |
| Player 4 | -- | -- | -- | -- | -- |
| Player 5 | -- | -- | -- | -- | -- |
| Player 6 | -- | -- | -- | -- | -- |
49ers Passing
| Player | ATT | CP | YDS | AVG | TD | INT | LG | RTG |
|---|---|---|---|---|---|---|---|---|
| Player 1 | -- | -- | -- | -- | -- | -- | -- | -- |
49ers Rushing
| Player | ATT | YDS | AVG | LG | TD |
|---|---|---|---|---|---|
| Player 1 | -- | -- | -- | -- | -- |
| Player 2 | -- | -- | -- | -- | -- |
| Player 3 | -- | -- | -- | -- | -- |
| Player 4 | -- | -- | -- | -- | -- |
49ers Receiving
| Player | ATT | YDS | AVG | LG | TD |
|---|---|---|---|---|---|
| Player 1 | -- | -- | -- | -- | -- |
| Player 2 | -- | -- | -- | -- | -- |
| Player 3 | -- | -- | -- | -- | -- |
| Player 4 | -- | -- | -- | -- | -- |
| Player 5 | -- | -- | -- | -- | -- |
| Player 6 | -- | -- | -- | -- | -- |
