Prediction: Jacksonville Jaguars vs San Francisco 49ers on 9/28/2025 | NFL Predictions - MyGameSim.com

NFL Prediction
Jacksonville Jaguars vs San Francisco 49ers on 9/28/2025

See the simulated matchup results between the 49ers and the Jaguars powered by MyGameSim. Get predicted scores, projected player stats, and key insights from our NFL Game Simulator.

FINAL SCORE
Spread: San Francisco 49ers by 3.5 Over/Under: 47.0

Prediction Accuracy

Winner: Incorrect
vs Spread: Correct
Over/Under: Incorrect

The predicted score is 49ers (2026): 16.8 - Jaguars (2026): 15.2, decided by < 7 pts 324 times (31.8%)

📊 Simulation Breakdown

49ers (2026)

🏆 Won 565 times (55.4%)

💪 Blowout wins (>20 pts): 90 (8.8%)

Jaguars (2026)

🏆 Won 455 times (44.6%)

💪 Blowout wins (>20 pts): 51 (5.0%)

⏳ Overtime

47 (4.6%)

🎯 Close Game (<7 pts)

324 (31.8%)

💻 Total Simulations

1,020

📈 Latest Lines

Spread
San Francisco 49ers -3.5 N/A | Jacksonville Jaguars +3.5 N/A
Total (O/U 47.0)
Over N/A | Under N/A

📊 Insights GOLD

Moneyline Edge:
Team +X.X% ⚡ Good Edge
Spread Cover:
Team covers XX% of sims ⚡
Over/Under:
XX% Over 🔥

📋 Projected Player Stats

Only Game Sim+ subscribers have access to view Projected Stats

Jaguars Passing

PlayerATTCPYDSAVGTDINTLGRTG
Player 1 -- -- -- -- -- -- -- --

Jaguars Rushing

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --

Jaguars Receiving

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --
Player 5 -- -- -- -- --
Player 6 -- -- -- -- --

49ers Passing

PlayerATTCPYDSAVGTDINTLGRTG
Player 1 -- -- -- -- -- -- -- --

49ers Rushing

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --

49ers Receiving

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --
Player 5 -- -- -- -- --
Player 6 -- -- -- -- --

Feedback