Prediction: New England Patriots vs Buffalo Bills on 10/5/2025 | NFL Predictions - MyGameSim.com

NFL Prediction
New England Patriots vs Buffalo Bills on 10/5/2025

See the simulated matchup results between the Bills and the Patriots powered by MyGameSim. Get predicted scores, projected player stats, and key insights from our NFL Game Simulator.

FINAL SCORE
Spread: Buffalo Bills by 8.5 Over/Under: 49.5

Prediction Accuracy

Winner: Incorrect
vs Spread: Correct
Over/Under: Correct

The predicted score is Bills (2026): 24.9 - Patriots (2026): 16.9, decided by < 7 pts 223 times (26.5%)

 
MATCHUP SIMULATION STATS
Bills vs. Patriots
 

(2026)

» Bills won 596 times (71.0%)

» Bills won by >20 pts 175 times (20.8%)

(2026)

» Patriots won 244 times (29.0%)

» Patriots won by >20 pts 25 times (3.0%)

 
PROJECTED PLAYER STATS
Only Game Sim+ subscribers have access to view Projected Stats

Patriots Passing

PlayerATTCPYDSAVGTDINTLGRTG
Player 1 -- -- -- -- -- -- -- --

Patriots Rushing

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --

Patriots Receiving

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --
Player 5 -- -- -- -- --
Player 6 -- -- -- -- --

Bills Passing

PlayerATTCPYDSAVGTDINTLGRTG
Player 1 -- -- -- -- -- -- -- --

Bills Rushing

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --

Bills Receiving

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --
Player 5 -- -- -- -- --
Player 6 -- -- -- -- --

Feedback