Prediction: Buffalo Bills vs Carolina Panthers on 10/26/2025 | NFL Predictions - MyGameSim.com

NFL Prediction
Buffalo Bills vs Carolina Panthers on 10/26/2025

See the simulated matchup results between the Panthers and the Bills powered by MyGameSim. Get predicted scores, projected player stats, and key insights from our NFL Game Simulator.

FINAL SCORE
Spread: Buffalo Bills by 7.5 Over/Under: 46.5

Prediction Accuracy

Winner: Incorrect
vs Spread: Incorrect
Over/Under: Incorrect

The predicted score is Panthers (2026): 21.6 - Bills (2026): 20.2, decided by < 7 pts 279 times (29.1%)

 
MATCHUP SIMULATION STATS
Panthers vs. Bills
 

(2026)

» Panthers won 525 times (54.7%)

» Panthers won by >20 pts 81 times (8.4%)

(2026)

» Bills won 435 times (45.3%)

» Bills won by >20 pts 60 times (6.3%)

 
PROJECTED PLAYER STATS
Only Game Sim+ subscribers have access to view Projected Stats

Bills Passing

PlayerATTCPYDSAVGTDINTLGRTG
Player 1 -- -- -- -- -- -- -- --

Bills Rushing

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --

Bills Receiving

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --
Player 5 -- -- -- -- --
Player 6 -- -- -- -- --

Panthers Passing

PlayerATTCPYDSAVGTDINTLGRTG
Player 1 -- -- -- -- -- -- -- --

Panthers Rushing

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --

Panthers Receiving

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --
Player 5 -- -- -- -- --
Player 6 -- -- -- -- --

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