NFL Prediction
San Francisco 49ers vs Arizona Cardinals on 11/16/2025
See the simulated matchup results between the Cardinals and the 49ers powered by MyGameSim. Get predicted scores, projected player stats, and key insights from our NFL Game Simulator.
FINAL SCORE
Spread: San Francisco 49ers by 3.5 Over/Under: 48.5
Prediction Accuracy
| Winner: | Incorrect |
| vs Spread: | Incorrect |
| Over/Under: | Correct |
The predicted score is Cardinals (2026): 30.9 - 49ers (2026): 24.3, decided by < 7 pts 300 times (29.4%)
MATCHUP SIMULATION STATS
Cardinals vs. 49ers
(2026)
» Cardinals won 716 times (70.2%)
» Cardinals won by >20 pts 140 times (13.7%)
(2026)
» 49ers won 304 times (29.8%)
» 49ers won by >20 pts 15 times (1.5%)
PROJECTED PLAYER STATS
Only Game Sim+ subscribers have access to view Projected Stats 
49ers Passing
| Player | ATT | CP | YDS | AVG | TD | INT | LG | RTG |
|---|---|---|---|---|---|---|---|---|
| Player 1 | -- | -- | -- | -- | -- | -- | -- | -- |
49ers Rushing
| Player | ATT | YDS | AVG | LG | TD |
|---|---|---|---|---|---|
| Player 1 | -- | -- | -- | -- | -- |
| Player 2 | -- | -- | -- | -- | -- |
| Player 3 | -- | -- | -- | -- | -- |
| Player 4 | -- | -- | -- | -- | -- |
49ers Receiving
| Player | ATT | YDS | AVG | LG | TD |
|---|---|---|---|---|---|
| Player 1 | -- | -- | -- | -- | -- |
| Player 2 | -- | -- | -- | -- | -- |
| Player 3 | -- | -- | -- | -- | -- |
| Player 4 | -- | -- | -- | -- | -- |
| Player 5 | -- | -- | -- | -- | -- |
| Player 6 | -- | -- | -- | -- | -- |
Cardinals Passing
| Player | ATT | CP | YDS | AVG | TD | INT | LG | RTG |
|---|---|---|---|---|---|---|---|---|
| Player 1 | -- | -- | -- | -- | -- | -- | -- | -- |
Cardinals Rushing
| Player | ATT | YDS | AVG | LG | TD |
|---|---|---|---|---|---|
| Player 1 | -- | -- | -- | -- | -- |
| Player 2 | -- | -- | -- | -- | -- |
| Player 3 | -- | -- | -- | -- | -- |
| Player 4 | -- | -- | -- | -- | -- |
Cardinals Receiving
| Player | ATT | YDS | AVG | LG | TD |
|---|---|---|---|---|---|
| Player 1 | -- | -- | -- | -- | -- |
| Player 2 | -- | -- | -- | -- | -- |
| Player 3 | -- | -- | -- | -- | -- |
| Player 4 | -- | -- | -- | -- | -- |
| Player 5 | -- | -- | -- | -- | -- |
| Player 6 | -- | -- | -- | -- | -- |
