Prediction: Carolina Panthers vs San Francisco 49ers on 11/24/2025 | NFL Predictions - MyGameSim.com

NFL Prediction
Carolina Panthers vs San Francisco 49ers on 11/24/2025

See the simulated matchup results between the 49ers and the Panthers powered by MyGameSim. Get predicted scores, projected player stats, and key insights from our NFL Game Simulator.

PREDICTED SCORE
Spread: San Francisco 49ers by 7 Over/Under: 47.5

The predicted score is 49ers (2026): 28.1 - Panthers (2026): 24.6, decided by < 7 pts 211 times (34.0%)


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MATCHUP SIMULATION STATS
49ers vs. Panthers
 

(2026)

» 49ers won 355 times (57.3%)

» 49ers won by >20 pts 62 times (10.0%)

(2026)

» Panthers won 265 times (42.7%)

» Panthers won by >20 pts 13 times (2.1%)

 
PROJECTED PLAYER STATS
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Panthers Passing

PlayerATTCPYDSAVGTDINTLGRTG
Player 1 -- -- -- -- -- -- -- --

Panthers Rushing

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --

Panthers Receiving

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --
Player 5 -- -- -- -- --
Player 6 -- -- -- -- --

49ers Passing

PlayerATTCPYDSAVGTDINTLGRTG
Player 1 -- -- -- -- -- -- -- --

49ers Rushing

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --

49ers Receiving

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --
Player 5 -- -- -- -- --
Player 6 -- -- -- -- --

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