NFL Prediction
San Francisco 49ers vs Indianapolis Colts on 12/22/2025
See the simulated matchup results between the Colts and the 49ers powered by MyGameSim. Get predicted scores, projected player stats, and key insights from our NFL Game Simulator.
PREDICTED SCORE
The predicted score is Colts (2026): - 49ers (2026): , decided by < 7 pts times (%)
Simulate the matchup NOW!
MATCHUP SIMULATION STATS
Colts vs. 49ers
(2026)
» Colts won times (%)
» Colts won by >20 pts times (%)
(2026)
» 49ers won times (%)
» 49ers won by >20 pts times (%)
PROJECTED PLAYER STATS
Only Game Sim+ subscribers have access to view Projected Stats 
49ers Passing
| Player | ATT | CP | YDS | AVG | TD | INT | LG | RTG |
|---|---|---|---|---|---|---|---|---|
| Player 1 | -- | -- | -- | -- | -- | -- | -- | -- |
49ers Rushing
| Player | ATT | YDS | AVG | LG | TD |
|---|---|---|---|---|---|
| Player 1 | -- | -- | -- | -- | -- |
| Player 2 | -- | -- | -- | -- | -- |
| Player 3 | -- | -- | -- | -- | -- |
| Player 4 | -- | -- | -- | -- | -- |
49ers Receiving
| Player | ATT | YDS | AVG | LG | TD |
|---|---|---|---|---|---|
| Player 1 | -- | -- | -- | -- | -- |
| Player 2 | -- | -- | -- | -- | -- |
| Player 3 | -- | -- | -- | -- | -- |
| Player 4 | -- | -- | -- | -- | -- |
| Player 5 | -- | -- | -- | -- | -- |
| Player 6 | -- | -- | -- | -- | -- |
Colts Passing
| Player | ATT | CP | YDS | AVG | TD | INT | LG | RTG |
|---|---|---|---|---|---|---|---|---|
| Player 1 | -- | -- | -- | -- | -- | -- | -- | -- |
Colts Rushing
| Player | ATT | YDS | AVG | LG | TD |
|---|---|---|---|---|---|
| Player 1 | -- | -- | -- | -- | -- |
| Player 2 | -- | -- | -- | -- | -- |
| Player 3 | -- | -- | -- | -- | -- |
| Player 4 | -- | -- | -- | -- | -- |
Colts Receiving
| Player | ATT | YDS | AVG | LG | TD |
|---|---|---|---|---|---|
| Player 1 | -- | -- | -- | -- | -- |
| Player 2 | -- | -- | -- | -- | -- |
| Player 3 | -- | -- | -- | -- | -- |
| Player 4 | -- | -- | -- | -- | -- |
| Player 5 | -- | -- | -- | -- | -- |
| Player 6 | -- | -- | -- | -- | -- |
