| Player | Injury | Status | Details |
|---|---|---|---|
| Andre Baccellia | Neck | Out | |
| Bam Knight | Ankle | Out | |
| Bilal Nichols | Knee | Out | |
| Blake Gillikin | Back | Out | |
| Evan Brown | Personal | Out | |
| Garrett Williams | Achilles | Out | |
| Greg Dortch | Chest | Out | |
| J.J. Russell | Concussion | Out | |
| James Conner | Foot | Out | |
| Joey Blount | Neck | Out | |
| Jonah Williams | Shoulder | Out | |
| Josh Sweat | Ankle | Questionable | |
| Kei'Trel Clark | Back | Out | |
| Kitan Crawford | Ankle | Out | |
| Kyler Murray | Foot | Out | |
| Mack Wilson | Ribs | Out | |
| Marvin Harrison | Foot | Out | |
| Paris Johnson | Knee - MCL | Out | |
| Sean Murphy-Bunting | Knee | Out | |
| Simi Fehoko | Wrist | Out | |
| Starling Thomas | Knee - ACL | Out | |
| Tip Reiman | Ankle | Out | |
| Travis Vokolek | Neck | Out | |
| Trey Benson | Knee - Meniscus | Out | |
| Valentin Senn | Undisclosed | Out | |
| Walter Nolen | Knee | Out | |
| Will Hernandez | Hip | Out | |
| Zay Jones | Achilles | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| A.J. Terrell | Illness | Questionable | |
| Billy Bowman | Achilles | Out | |
| Bralen Trice | Knee | Out | |
| Brandon Dorlus | Hamstring | Out | |
| Clark Phillips | Triceps | Out | |
| Darnell Mooney | Knee | Questionable | |
| DeAngelo Malone | Ankle | Out | |
| DeMarcco Hellams | Hamstring | Out | |
| Drake London | Knee - PCL | Questionable | |
| Emory Jones | Concussion | Out | |
| Kaleb McGary | Leg | Out | |
| KhaDarel Hodge | Shoulder | Out | |
| Kyle Pitts | Knee | Questionable | |
| Liam McCullough | Illness | Questionable | |
| Malik Verdon | Shoulder | Out | |
| Michael Penix | Knee - ACL | Out | |
| Mike Hughes | Ankle | Out | |
| Ruke Orhorhoro | Illness | Questionable | |
| Sam Roberts | Knee | Out | |
| Storm Norton | Foot | Out | |
| Troy Andersen | Knee | Out | |
| Tyrone Wheatley | Undisclosed | Out | |
| Zach Harrison | Knee | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Adisa Isaac | Elbow | Out | |
| Bilhal Kone | Knee | Out | |
| Broderick Washington | Achilles | Out | |
| Dayton Wade | Ribs | Out | |
| Justice Hill | Neck | Out | |
| Marlon Humphrey | Illness | Questionable | |
| Michael Pierce | Undisclosed | Out | |
| Nnamdi Madubuike | Neck | Out | |
| Rashod Bateman | Illness | Out | |
| Robert Longerbeam | Knee | Out | |
| Taven Bryan | Knee | Out | |
| Teddye Buchanan | Knee - ACL | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Chase Lundt | Knee | Out | |
| Curtis Samuel | Elbow | Out | |
| Dalton Kincaid | Knee | Questionable | |
| Damar Hamlin | Pectoral | Out | |
| DaQuan Jones | Calf | Out | |
| Darius Slay | Personal | Reserve-DNR | |
| Deone Walker | Illness | Questionable | |
| DeWayne Carter | Achilles | Out | |
| Dorian Strong | Neck | Out | |
| Ed Oliver | Biceps | Out | |
| Joey Bosa | Hamstring | Questionable | |
| Jordan Phillips | Ankle | Questionable | |
| Jordan Poyer | Hamstring | Out | |
| Landon Jackson | Knee | Out | |
| Michael Hoecht | Achilles | Out | |
| Taylor Rapp | Knee | Out | |
| Terrel Bernard | Calf | Out | |
| Tyler Bass | Hip | Out | |
| Wande Owens | Undisclosed | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Bobby Brown | Concussion | Questionable | |
| Brady Christensen | Achilles | Out | |
| Chandler Zavala | Calf | Out | |
| Claudin Cherelus | Calf | Out | |
| Corey Thornton | Lower Leg | Out | |
| D'Anthony Bell | Coach's Decision | Out | |
| Damarri Mathis | Knee - ACL | Out | |
| David Moore | Elbow | Out | |
| Demani Richardson | Coach's Decision | Out | |
| Hunter Renfrow | Coach's Decision | Out | |
| Ja'Tavion Sanders | Lower Leg | Out | |
| Jared Harrison-Hunte | Coach's Decision | Out | |
| Jonathon Brooks | Knee - ACL | Out | |
| Patrick Jones | Back | Out | |
| Popo Aumavae | Achilles | Out | |
| Robert Hunt | Biceps | Out | |
| Robert Rochell | Concussion | Out | |
| Tershawn Wharton | Hamstring | Out | |
| Trevin Wallace | Shoulder | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Braxton Jones | Knee | Out | |
| Dayo Odeyingbo | Achilles | Out | |
| Deion Hankins | Quadriceps | Out | |
| Jaquan Brisker | Illness | Questionable | |
| Joe Tryon-Shoyinka | Concussion | Out | |
| Kiran Amegadjie | Elbow | Out | |
| Kyler Gordon | Groin | Out | |
| Nick McCloud | Illness | Questionable | |
| Noah Sewell | Achilles | Out | |
| Ozzy Trapilo | Knee | Questionable | |
| Rome Odunze | Foot | Questionable | |
| Roschon Johnson | Thumb | Out | |
| Shemar Turner | Knee - ACL | Out | |
| Terell Smith | Knee | Out | |
| Zah Frazier | Personal | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| B.J. Hill | Ankle | Questionable | |
| Brian Asamoah | Knee | Out | |
| Cam Grandy | Chest | Questionable | |
| Cam Taylor-Britt | Foot | Out | |
| Charlie Jones | Ankle | Out | |
| Cordell Volson | Shoulder | Out | |
| Erick All | Knee - ACL | Out | |
| Joseph Ossai | Ankle | Out | |
| Josh Newton | Hamstring | Out | |
| Kris Jenkins | Ankle | Out | |
| Marco Wilson | Hamstring | Out | |
| Matt Lee | Knee | Out | |
| Sam Hubbard | Undisclosed | Out | |
| Trey Hendrickson | Pelvis | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Anthony Kendall | Undisclosed | Out | |
| Carson Schwesinger | Ankle | Out | |
| David Bell | Hip | Out | |
| David Njoku | Knee | Out | |
| Dawand Jones | Knee | Out | |
| DeAndre Carter | Knee | Out | |
| Deshaun Watson | Achilles | Out | |
| Dom Jones | Knee | Out | |
| Elerson Smith | Undisclosed | Out | |
| Ethan Pocic | Achilles | Out | |
| Harold Fannin | Groin | Out | |
| Jack Conklin | Concussion | Out | |
| Jeremiah Owusu-Koramoah | Neck | Out | |
| Jerome Ford | Shoulder | Out | |
| Jordan Hicks | Undisclosed | Out | |
| Justin Osborne | Undisclosed | Out | |
| Kingsley Eguakun | Knee | Questionable | |
| Maliek Collins | Quadriceps | Out | |
| Martin Emerson | Achilles | Out | |
| Myles Harden | Shoulder | Questionable | |
| Nathaniel Watson | Biceps | Out | |
| Quinshon Judkins | Ankle | Out | |
| Winston Reid | Back | Out | |
| Wyatt Teller | Calf | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Ajani Cornelius | Knee | Out | |
| DaRon Bland | Foot | Out | |
| DeMarvion Overshown | Concussion | Out | |
| Jack Sanborn | Groin | Out | |
| Javonte Williams | Shoulder | Out | |
| Josh Butler | Knee - ACL | Questionable | |
| Juanyeh Thomas | Migraine | Out | |
| Malik Davis | Eye | Out | |
| Miles Sanders | Knee | Out | |
| Payton Turner | Ribs | Out | |
| Phil Mafah | Shoulder | Questionable | |
| Rob Jones | Neck | Out | |
| Shavon Revel | Concussion | Out | |
| T.J. Bass | Knee | Out | |
| Trevor Keegan | Neck | Out | |
| Tyler Guyton | Ankle | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Brandon Jones | Pectoral | Out | |
| Dre Greenlaw | Hamstring | Out | |
| Drew Sanders | Foot | Out | |
| J.K. Dobbins | Foot | Out | |
| John Franklin-Myers | Hip | Questionable | |
| Johnny Walker | Undisclosed | Out | |
| Karene Reid | Hamstring | Out | |
| Lucas Krull | Foot | Out | |
| Luke Wattenberg | Shoulder | Out | |
| Matt Henningsen | Achilles | Out | |
| Matt Peart | Knee - MCL | Out | |
| Michael Burton | Hamstring | Out | |
| Nick Gargiulo | Knee | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Alex Anzalone | Concussion | Out | |
| Alim McNeill | Abdomen | Out | |
| Amon-Ra St. Brown | Knee | Questionable | |
| Brian Branch | Achilles | Out | |
| Brock Wright | Neck | Out | |
| Christian Mahogany | Illness | Questionable | |
| Colby Sorsdal | Leg | Out | |
| Dan Jackson | Leg | Out | |
| Ennis Rakestraw | Shoulder | Out | |
| Ezekiel Turner | Foot | Out | |
| Frank Ragnow | Hamstring | Out | |
| Giovanni Manu | Knee | Out | |
| Jamarco Jones | Achilles | Out | |
| Josh Paschal | Back | Out | |
| Kayode Awosika | Illness | Questionable | |
| Kerby Joseph | Knee | Out | |
| Kye Robichaux | Undisclosed | Out | |
| Levi Onwuzurike | Knee - ACL | Out | |
| Penei Sewell | Ankle | Out | |
| Sam LaPorta | Back | Out | |
| Taylor Decker | Shoulder | Questionable | |
| Terrion Arnold | Shoulder | Out | |
| Thomas Harper | Concussion | Out | |
| Trystan Colon | Wrist | Out | |
| Zach Cunningham | Hamstring | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Devonte Wyatt | Ankle | Out | |
| Donovan Jennings | Neck | Out | |
| Dontayvion Wicks | Concussion | Doubtful | |
| Elgton Jenkins | Lower Leg | Out | |
| John FitzPatrick | Achilles | Out | |
| John Williams | Back | Out | |
| Jordon Riley | Achilles | Out | |
| Kamal Hadden | Ankle | Out | |
| Kristian Welch | Ankle | Out | |
| Malik Willis | Shoulder | Questionable | |
| MarShawn Lloyd | Hamstring | Out | |
| Micah Parsons | Knee - ACL | Out | |
| Nate Hobbs | Knee | Out | |
| Nick Niemann | Pectoral | Out | |
| Savion Williams | Foot | Out | |
| Travis Glover | Shoulder | Out | |
| Tucker Kraft | Knee - ACL | Out | |
| Zach Tom | Back | Questionable | |
| Zayne Anderson | Ankle | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Ajani Carter | Hamstring | Out | |
| Brevin Jordan | Knee | Out | |
| Darrell Taylor | Ankle | Out | |
| Folorunso Fatukasi | Shoulder | Out | |
| Jake Hansen | Chest | Out | |
| Jamal Hill | Calf | Out | |
| Jaylen Reed | Forearm | Out | |
| Jaylin Smith | Undisclosed | Out | |
| Jimmie Ward | Foot | Out | |
| Joe Mixon | Foot | Out | |
| Kamari Lassiter | Ankle | Out | |
| Kurt Hinish | Undisclosed | Out | |
| Kyonte Hamilton | Ankle | Out | |
| M.J. Stewart | Quadriceps | Out | |
| Mario Edwards | Pectoral | Out | |
| Ronald Darby | Undisclosed | Out | |
| Tank Dell | Knee - ACL + MCL | Out | |
| Tim Settle | Foot | Out | |
| Trent Brown | Ankle | Questionable |
| Player | Injury | Status | Details |
|---|---|---|---|
| Anthony Gould | Foot | Out | |
| Anthony Richardson | Eye | Out | |
| Blake Freeland | Leg | Out | |
| Braden Smith | Concussion | Out | |
| Charvarius Ward | Concussion | Out | |
| Chris Lammons | Foot | Out | |
| D.J. Montgomery | Undisclosed | Out | |
| Daniel Jones | Achilles | Out | |
| Daniel Scott | Knee | Out | |
| DeForest Buckner | Neck | Out | |
| Drew Ogletree | Neck | Out | |
| Hunter Wohler | Foot | Out | |
| Jack Wilson | Undisclosed | Out | |
| Jacob Phillips | Biceps | Out | |
| Justin Walley | Knee - ACL | Out | |
| Salvon Ahmed | Ankle | Out | |
| Sauce Gardner | Calf | Out | |
| Spencer Shrader | Knee - ACL + MCL | Out | |
| Will Mallory | Chest | Out | |
| Xavien Howard | Personal | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Caleb Ransaw | Lower Body | Out | |
| Cooper Hodges | Knee | Out | |
| Dennis Daley | Undisclosed | Out | |
| Jack Kiser | Undisclosed | Out | |
| Jalen McLeod | Ankle | Out | |
| Joshua Cephus | Undisclosed | Out | |
| Jourdan Lewis | Foot | Out | |
| Patrick Mekari | Back | Out | |
| Travis Hunter | Knee | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Brandon George | Undisclosed | Out | |
| Christian Roland-Wallace | Back | Out | |
| Deon Bush | Achilles | Out | |
| Eric Scott | Undisclosed | Out | |
| Ethan Driskell | Appendix | Out | |
| Felix Anudike-Uzomah | Hamstring | Out | |
| Gardner Minshew | Knee | Out | |
| George Karlaftis | Rest | Questionable | |
| Isiah Pacheco | Rest | Questionable | |
| Jake Briningstool | Hamstring | Out | |
| Janarius Robinson | Foot | Out | |
| Jawaan Taylor | Elbow | Out | |
| Jaylen Watson | Groin | Out | |
| Jaylon Moore | Knee | Questionable | |
| Jerry Tillery | Personal | Questionable | |
| Josh Simmons | Wrist | Out | |
| Keaontay Ingram | Undisclosed | Out | |
| Leo Chenal | Shoulder | Out | |
| Nikko Remigio | Knee | Out | |
| Omarr Norman-Lott | Knee - ACL | Out | |
| Patrick Mahomes | Knee - ACL | Out | |
| Rashee Rice | Concussion | Out | |
| Trent McDuffie | Knee | Out | |
| Trey Smith | Ankle | Out | |
| Tyquan Thornton | Concussion | Out | |
| Wanya Morris | Knee | Out | |
| Xavier Worthy | Illness | Doubtful |
| Player | Injury | Status | Details |
|---|---|---|---|
| Adam Butler | Biceps | Out | |
| Brennan Jackson | Foot | Out | |
| Brock Bowers | Knee - PCL | Out | |
| Dylan Parham | Illness | Out | |
| Geno Smith | Ankle | Out | |
| Jackson Powers-Johnson | Ankle | Out | |
| Jeremy Chinn | Back | Out | |
| Jordan Meredith | Ankle | Out | |
| Kolton Miller | Ankle | Out | |
| Kyu Blu Kelly | Knee | Out | |
| Maxx Crosby | Knee | Out | |
| Raheem Mostert | Knee | Questionable |
| Player | Injury | Status | Details |
|---|---|---|---|
| Benjamin St-Juste | Shoulder | Questionable | |
| Bradley Bozeman | Concussion | Questionable | |
| Del'Shawn Phillips | Hamstring | Questionable | |
| Denzel Perryman | Suspension | Out | |
| Elijah Molden | Hamstring | Out | |
| Eric Rogers | Undisclosed | Out | |
| Hassan Haskins | Concussion | Questionable | |
| Jamaree Salyer | Hamstring | Doubtful | |
| Joe Alt | Ankle | Out | |
| Jordan Oladokun | Undisclosed | Out | |
| Josh Fuga | Undisclosed | Out | |
| Junior Colson | Shoulder | Out | |
| Kimani Vidal | Neck | Questionable | |
| Mike Williams | Undisclosed | Reserve-Ex | |
| Najee Harris | Achilles | Out | |
| Nikko Reed | Hamstring | Out | |
| Omarion Hampton | Ankle | Out | |
| Rashawn Slater | Kneecap | Out | |
| Rick Lovato | Undisclosed | Out | |
| RJ Mickens | Shoulder | Questionable | |
| Savion Washington | Undisclosed | Out | |
| Tucker Fisk | Ankle | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Alaric Jackson | Knee | Questionable | |
| Blake Corum | Ankle | Questionable | |
| Davante Adams | Hamstring | Questionable | |
| Josh Wallace | Ankle | Out | |
| Keir Thomas | Undisclosed | Out | |
| Kevin Dotson | Ankle | Out | |
| Kyren Williams | Ankle | Questionable | |
| Omar Speights | Ankle | Questionable | |
| Quentin Lake | Elbow | Out | |
| Rob Havenstein | Ankle | Out | |
| Terrance Ferguson | Hamstring | Doubtful | |
| Tyler Higbee | Ankle | Questionable |
| Player | Injury | Status | Details |
|---|---|---|---|
| Aaron Brewer | Neck | Questionable | |
| Alexander Mattison | Neck | Out | |
| Artie Burns | Knee - ACL | Out | |
| Austin Jackson | Back | Questionable | |
| Benito Jones | Back | Out | |
| Caleb Johnson | Shoulder | Out | |
| Chop Robinson | Concussion | Questionable | |
| Darren Waller | Groin | Out | |
| De'Von Achane | Shoulder | Doubtful | |
| Dee Eskridge | Toe | Out | |
| Elijah Campbell | Ankle | Out | |
| Germain Ifedi | Undisclosed | Out | |
| Isaiah Johnson | Knee | Out | |
| Jalin Conyers | Leg | Out | |
| James Daniels | Pectoral | Out | |
| Jason Maitre | Undisclosed | Out | |
| Jason Sanders | Hip | Out | |
| Jaylen Waddle | Ribs | Questionable | |
| Jordan Colbert | Neck | Out | |
| Jordyn Brooks | Hamstring | Questionable | |
| JuJu Brents | Foot | Out | |
| Kader Kohou | Knee - ACL | Out | |
| Liam Eichenberg | Undisclosed | Out | |
| Minkah Fitzpatrick | Calf | Out | |
| Obinna Eze | Undisclosed | Out | |
| Quinton Bell | Illness | Questionable | |
| Storm Duck | Knee | Out | |
| Terron Armstead | Undisclosed | Out | |
| Tyreek Hill | Knee - ACL | Out | |
| Yodny Cajuste | Undisclosed | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Aaron Jones | Hip | Out | |
| Carson Wentz | Shoulder | Out | |
| Christian Darrisaw | Knee | Out | |
| Dwight McGlothern | Hip | Questionable | |
| Elijah Williams | Ankle | Out | |
| Gavin Bartholomew | Back | Out | |
| Jeff Okudah | Concussion | Out | |
| Jonathan Greenard | Shoulder | Out | |
| Josh Metellus | Shoulder | Out | |
| Matt Nelson | Undisclosed | Out | |
| Myles Price | Ankle | Out | |
| Rondale Moore | Knee | Out | |
| Ryan Kelly | Concussion | Out | |
| T.J. Hockenson | Shoulder | Out | |
| Zeke Correll | Ankle | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Alex Austin | Wrist | Out | |
| Antonio Gibson | Knee - ACL | Out | |
| Brock Lampe | Undisclosed | Out | |
| Charles Woods | Foot | Questionable | |
| Deneric Prince | Undisclosed | Out | |
| Harold Landry | Knee | Out | |
| Isaiah Iton | Hip | Out | |
| Jack Westover | Ankle | Questionable | |
| Jaquelin Roy | Undisclosed | Out | |
| Jared Wilson | Concussion | Out | |
| Joshua Farmer | Hamstring | Out | |
| Khyiris Tonga | Foot | Out | |
| Lan Larison | Foot | Out | |
| Mack Hollins | Abdomen | Out | |
| Marcellas Dial | Knee - ACL | Out | |
| Robert Spillane | Ankle | Out | |
| Terrell Jennings | Concussion | Out | |
| Wes Schweitzer | Undisclosed | Out | |
| Yasir Durant | Undisclosed | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Alvin Kamara | Knee - MCL | Out | |
| Bryan Bresee | Knee | Out | |
| Bub Means | Lower Leg | Out | |
| Chris Olave | Illness | Out | |
| Demario Davis | Calf | Questionable | |
| Derek Carr | Shoulder | Out | |
| Devaughn Vele | Shoulder | Out | |
| Devin Neal | Hamstring | Out | |
| Dillon Radunz | Knee | Questionable | |
| Erik McCoy | Biceps | Out | |
| Foster Moreau | Ankle | Out | |
| Ja'Lynn Polk | Shoulder | Out | |
| Jack Stoll | Knee | Out | |
| Julian Blackmon | Shoulder - Labrum | Out | |
| Kendre Miller | Knee - ACL | Out | |
| Landon Young | Ankle | Out | |
| Mason Pline | Upper Body | Out | |
| Mason Tipton | Groin | Out | |
| Michael Davis | Shoulder | Out | |
| Nathan Shepherd | Ankle | Out | |
| Nick Saldiveri | Knee | Out | |
| Ryan Ramczyk | Undisclosed | Out | |
| Spencer Rattler | Finger | Questionable | |
| Trey Palmer | Ankle | Out | |
| Tyrann Mathieu | Undisclosed | Out | |
| Vernon Broughton | Hip | Out | |
| Will Clapp | Foot | Out | |
| Zaire Mitchell-Paden | Knee | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Andrew Thomas | Hamstring | Out | |
| Anthony Johnson | Undisclosed | Out | |
| Beaux Collins | Concussion | Out | |
| Bryce Ford-Wheaton | Achilles | Out | |
| Cam Skattebo | Ankle | Out | |
| Chris Board | Chest | Out | |
| Cor'Dale Flott | Knee | Out | |
| D.J. Davidson | Neck | Out | |
| Da'Quan Felton | Undisclosed | Out | |
| Evan Neal | Neck | Out | |
| Graham Gano | Neck | Out | |
| Jalin Hyatt | Illness | Questionable | |
| Jevon Holland | Knee | Out | |
| John Michael Schmitz | Finger | Out | |
| Joshua Ezeudu | Calf | Out | |
| Kayvon Thibodeaux | Shoulder | Out | |
| Malik Nabers | Knee - ACL | Out | |
| Micah McFadden | Foot | Out | |
| Nic Jones | Shoulder | Out | |
| Rakeem Nunez-Roches | Ankle | Out | |
| T.J. Moore | Upper Leg | Out | |
| Theo Johnson | Illness | Out | |
| Thomas Fidone | Foot | Out | |
| Tyler Nubin | Neck | Out | |
| Victor Dimukeje | Knee | Out | |
| Wan'Dale Robinson | Ribs | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Alijah Vera-Tucker | Triceps | Out | |
| Andre Cisco | Pectoral | Out | |
| Azareye'h Thomas | Shoulder | Out | |
| Braelon Allen | Knee - MCL | Out | |
| Brandon Stephens | Neck | Out | |
| Breece Hall | Knee | Out | |
| Francisco Mauigoa | Neck | Out | |
| Garrett Wilson | Knee | Out | |
| Gus Hartwig | Undisclosed | Out | |
| Irvin Charles | Knee - ACL | Out | |
| Isaiah Davis | Concussion | Out | |
| Isaiah Oliver | Knee | Out | |
| Jarvis Brownlee | Hip | Out | |
| Jay Tufele | Foot | Out | |
| Jelani Woods | Hamstring | Out | |
| Joe Tippmann | Hip | Questionable | |
| Jordan Travis | Lower Leg | Out | |
| Josh Reynolds | Hip | Out | |
| Justin Fields | Knee | Out | |
| Kris Boyd | Abdomen | Out | |
| Marcelino McCrary-Ball | Hamstring | Out | |
| Mason Taylor | Neck | Out | |
| Micheal Clemons | Ankle | Out | |
| Qwan'tez Stiggers | Knee | Out | |
| Tony Adams | Groin | Out | |
| Tyler Baron | Knee | Out | |
| Tyrod Taylor | Knee | Questionable | |
| Will McDonald | Knee | Out | |
| Xavier Newman-Johnson | Knee | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Andrew Mukuba | Ankle | Out | |
| Azeez Ojulari | Hamstring | Out | |
| Ben VanSumeren | Knee | Out | |
| Dallas Goedert | Knee | Out | |
| Jaelan Phillips | Ankle | Out | |
| Jaire Alexander | Undisclosed | Out | |
| Jalen Carter | Hip | Out | |
| Johnny Wilson | Knee | Out | |
| Lane Johnson | Foot | Out | |
| Marcus Epps | Concussion | Out | |
| Myles Hinton | Back | Out | |
| Nakobe Dean | Hamstring | Out | |
| Ogbo Okoronkwo | Triceps | Out | |
| Willie Lampkin | Knee | Out | |
| Za'Darius Smith | Undisclosed | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Broderick Jones | Neck | Out | |
| Calvin Anderson | Knee | Out | |
| Cory Trice | Knee | Out | |
| Daniel Ekuale | Knee - ACL | Out | |
| Darnell Washington | Forearm | Out | |
| Dean Lowry | Knee | Out | |
| DeShon Elliott | Knee | Out | |
| DK Metcalf | Suspension | Out | |
| Donald Parham | Achilles | Out | |
| Donte Kent | Ankle | Out | |
| Isaiahh Loudermilk | Ankle | Out | |
| Jacob Slade | Undisclosed | Out | |
| Max Scharping | Knee | Out | |
| Miles Killebrew | Knee | Out | |
| Skylar Thompson | Hamstring | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Ben Bartch | Foot | Out | |
| Brandon Aiyuk | Knee - ACL + MCL | Reserve-DNR | |
| Chase Lucas | Coach's Decision | Out | |
| Curtis Robinson | Coach's Decision | Out | |
| Dee Winters | Ankle | Questionable | |
| Fred Warner | Ankle | Out | |
| Isaac Guerendo | Coach's Decision | Out | |
| Jacob Cowing | Hamstring | Out | |
| Jakob Robinson | Forearm | Out | |
| Kevin Givens | Coach's Decision | Out | |
| Kurtis Rourke | Knee | Out | |
| Mykel Williams | Knee - ACL | Out | |
| Nick Bosa | Knee - ACL | Out | |
| Nick Martin | Concussion | Out | |
| Patrick Taylor | Shoulder | Out | |
| Ricky Pearsall | Knee | Out | |
| Robert Beal | Coach's Decision | Out | |
| Tarron Jackson | Undisclosed | Out | |
| Tatum Bethune | Groin | Questionable | |
| Tre Tomlinson | Undisclosed | Out | |
| Trent Taylor | Undisclosed | Out | |
| Trent Williams | Hamstring | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| AJ Finley | Knee | Out | |
| Bryce Cabeldue | Coach's Decision | Out | |
| Charles Cross | Hamstring | Out | |
| Chazz Surratt | Ankle | Out | |
| Coby Bryant | Knee | Out | |
| Cody White | Groin | Out | |
| Elijah Arroyo | Knee | Out | |
| George Holani | Hamstring | Out | |
| Jalen Milroe | Coach's Decision | Out | |
| Jared Ivey | Coach's Decision | Out | |
| Kenny McIntosh | Knee - ACL | Out | |
| Mason Richman | Coach's Decision | Out | |
| Nick Kallerup | Coach's Decision | Out | |
| Tory Horton | Shin | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Anthony Nelson | Knee | Out | |
| Anthony Walker | Ankle | Questionable | |
| Ben Bredeson | Knee | Out | |
| Cody Mauch | Knee | Out | |
| Connor Bazelak | Coach's Decision | Out | |
| David Walker | Knee | Out | |
| Elijah Klein | Coach's Decision | Out | |
| Elijah Simmons | Coach's Decision | Out | |
| Garret Greenfield | Undisclosed | Out | |
| J.J. Roberts | Knee | Out | |
| Jaden Smith | Undisclosed | Out | |
| Jamel Dean | Shoulder | Out | |
| Ko Kieft | Leg | Out | |
| Sterling Shepard | Coach's Decision | Out | |
| Zyon McCollum | Hip | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Amani Hooker | Ankle | Doubtful | |
| Anfernee Orji | Knee - ACL | Out | |
| Arden Key | Hip | Out | |
| Blake Hance | Shoulder | Out | |
| Calvin Ridley | Lower Leg | Out | |
| Gunnar Helm | Toe | Out | |
| Jalyn Armour-Davis | Achilles | Out | |
| Kevin Winston | Hamstring | Out | |
| L'Jarius Sneed | Quadriceps | Out | |
| Marcus Harris | Knee | Out | |
| Mike Brown | Ankle | Out | |
| Oluwafemi Oladejo | Lower Leg | Out | |
| Van Jefferson | Forearm | Out | |
| Will Levis | Shoulder | Out | |
| Xavier Woods | Hamstring | Out |
| Player | Injury | Status | Details |
|---|---|---|---|
| Austin Ekeler | Achilles | Out | |
| Brandon Coleman | Knee | Questionable | |
| Deatrich Wise | Quadriceps | Out | |
| Dorance Armstrong | Knee | Out | |
| Eddie Goldman | Concussion | Out | |
| Javontae Jean-Baptiste | Pectoral | Out | |
| Jayden Daniels | Elbow | Out | |
| Jaylin Lane | Ankle | Out | |
| Laremy Tunsil | Oblique | Out | |
| Lucas Niang | Knee - ACL | Out | |
| Luke McCaffrey | Collarbone | Out | |
| Marcus Mariota | Hand | Out | |
| Marshon Lattimore | Knee - ACL | Out | |
| Noah Brown | Ribs | Out | |
| Sam Cosmi | Concussion | Out | |
| Trey Amos | Lower Leg | Out | |
| Tyler Biadasz | Knee | Out | |
| Tyree Jackson | Undisclosed | Out | |
| Zach Ertz | Knee - ACL | Out |