Prediction: New Orleans Saints vs Buffalo Bills on 9/28/2025 | NFL Predictions - MyGameSim.com

NFL Prediction
New Orleans Saints vs Buffalo Bills on 9/28/2025

See the simulated matchup results between the Bills and the Saints powered by MyGameSim. Get predicted scores, projected player stats, and key insights from our NFL Game Simulator.

PREDICTED SCORE

The predicted score is Bills (2026): 26.1 - Saints (2026): 10.2, decided by < 5 pts 22 times (15.7%)

 
MATCHUP SIMULATION STATS
Bills vs. Saints
 

(2026)

» Bills won 126 times (90.0%)

» Bills won by >20 pts 51 times (36.4%)

(2026)

» Saints won 14 times (10.0%)

» Saints won by >20 pts 0 times (0.0%)

 
PROJECTED PLAYER STATS
Only Game Sim+ subscribers have access to view Projected Stats

Saints Passing

PlayerATTCPYDSAVGTDINTLGRTG
Player 1 -- -- -- -- -- -- -- --

Saints Rushing

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --

Saints Receiving

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --
Player 5 -- -- -- -- --
Player 6 -- -- -- -- --

Bills Passing

PlayerATTCPYDSAVGTDINTLGRTG
Player 1 -- -- -- -- -- -- -- --

Bills Rushing

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --

Bills Receiving

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --
Player 5 -- -- -- -- --
Player 6 -- -- -- -- --

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