Prediction: Indianapolis Colts vs Los Angeles Rams on 9/28/2025 | NFL Predictions - MyGameSim.com

NFL Prediction
Indianapolis Colts vs Los Angeles Rams on 9/28/2025

See the simulated matchup results between the Rams and the Colts powered by MyGameSim. Get predicted scores, projected player stats, and key insights from our NFL Game Simulator.

PREDICTED SCORE

The predicted score is Rams (2026): 20.9 - Colts (2026): 18.0, decided by < 5 pts 35 times (25.0%)

 
MATCHUP SIMULATION STATS
Rams vs. Colts
 

(2026)

» Rams won 88 times (62.9%)

» Rams won by >20 pts 15 times (10.7%)

(2026)

» Colts won 52 times (37.1%)

» Colts won by >20 pts 10 times (7.1%)

 
PROJECTED PLAYER STATS
Only Game Sim+ subscribers have access to view Projected Stats

Colts Passing

PlayerATTCPYDSAVGTDINTLGRTG
Player 1 -- -- -- -- -- -- -- --

Colts Rushing

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --

Colts Receiving

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --
Player 5 -- -- -- -- --
Player 6 -- -- -- -- --

Rams Passing

PlayerATTCPYDSAVGTDINTLGRTG
Player 1 -- -- -- -- -- -- -- --

Rams Rushing

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --

Rams Receiving

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --
Player 5 -- -- -- -- --
Player 6 -- -- -- -- --

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