Prediction: Jacksonville Jaguars vs San Francisco 49ers on 9/28/2025 | NFL Predictions - MyGameSim.com

NFL Prediction
Jacksonville Jaguars vs San Francisco 49ers on 9/28/2025

See the simulated matchup results between the 49ers and the Jaguars powered by MyGameSim. Get predicted scores, projected player stats, and key insights from our NFL Game Simulator.

PREDICTED SCORE

The predicted score is 49ers (2026): 18.2 - Jaguars (2026): 15.4, decided by < 5 pts 38 times (27.1%)

 
MATCHUP SIMULATION STATS
49ers vs. Jaguars
 

(2026)

» 49ers won 86 times (61.4%)

» 49ers won by >20 pts 18 times (12.9%)

(2026)

» Jaguars won 54 times (38.6%)

» Jaguars won by >20 pts 7 times (5.0%)

 
PROJECTED PLAYER STATS
Only Game Sim+ subscribers have access to view Projected Stats

Jaguars Passing

PlayerATTCPYDSAVGTDINTLGRTG
Player 1 -- -- -- -- -- -- -- --

Jaguars Rushing

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --

Jaguars Receiving

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --
Player 5 -- -- -- -- --
Player 6 -- -- -- -- --

49ers Passing

PlayerATTCPYDSAVGTDINTLGRTG
Player 1 -- -- -- -- -- -- -- --

49ers Rushing

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --

49ers Receiving

PlayerATTYDSAVGLGTD
Player 1 -- -- -- -- --
Player 2 -- -- -- -- --
Player 3 -- -- -- -- --
Player 4 -- -- -- -- --
Player 5 -- -- -- -- --
Player 6 -- -- -- -- --

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