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Predictions refresh daily and may update during the day when key injuries or depth chart changes occur.

MLB Predictions for 9/16/2025

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Odds: Line | O/U | Money Line

9/16/2025 MLB Games
Time *ET	Matchup	Prediction	Actual	Result
1:05 PM	Atlanta Braves @ Washington Nationals Jose Suarez vs Jake Irvin by 1.5 +/- Lineups Jurickson Profar LF Matt Olson 1B Ronald Acuna DH Drake Baldwin C Ozzie Albies 2B Ha-Seong Kim SS Michael Harris CF Eli White RF Vidal Brujan 3B Jose Suarez P CJ Abrams SS James Wood DH Andres Chaparro 1B Daylen Lile LF Jorge Alfaro C Luis Garcia 2B Dylan Crews RF Brady House 3B Jacob Young CF Jake Irvin P	Atlanta Braves WIN 4.8-4.0 by 0.7 Prediction	Atlanta Braves wins 6-3
6:40 PM	Chicago Cubs @ Pittsburgh Pirates Cade Horton vs Paul Skenes by 1.5 +/- Lineups Michael Busch 1B Nico Hoerner 2B Ian Happ LF Moises Ballesteros DH Carson Kelly C Pete Crow-Armstrong CF Dansby Swanson SS Willi Castro RF Matt Shaw 3B Cade Horton P Jared Triolo 3B Spencer Horwitz 1B Bryan Reynolds DH Oneil Cruz CF Nick Gonzales SS Jack Suwinski LF Nick Yorke 2B Alexander Canario RF Henry Davis C Paul Skenes P	Chicago Cubs WIN 4.0-3.5 by 0.5 Prediction	Chicago Cubs wins 4-1
6:40 PM	Cleveland Guardians @ Detroit Tigers Joey Cantillo vs Casey Mize by 1.5 +/- Lineups Steven Kwan LF Daniel Schneemann CF Jose Ramirez 3B Kyle Manzardo DH Bo Naylor C Gabriel Arias SS Nolan Jones RF C.J. Kayfus 1B Brayan Rocchio 2B Joey Cantillo P Jahmai Jones DH Gleyber Torres 2B Wenceel Perez RF Spencer Torkelson 1B Riley Greene LF Andy Ibanez 3B Dillon Dingler C Parker Meadows CF Javier Baez SS Casey Mize P	Detroit Tigers WIN 4.8-3.8 by 1.0 Prediction	Cleveland Guardians wins 7-5
6:45 PM	Athletics @ Boston Red Sox Jeffrey Springs vs Connelly Early by 1.5 +/- Lineups Shea Langeliers C Jacob Wilson SS Nick Kurtz 1B Brent Rooker DH Colby Thomas RF Darell Hernaiz 2B Brett Harris 3B Lawrence Butler CF Max Schuemann LF Jeffrey Springs P Romy Gonzalez 1B Alex Bregman 3B Trevor Story SS Rob Refsnyder DH Carlos Narvaez C Nate Eaton RF Nick Sogard 2B Jarren Duran LF Ceddanne Rafaela CF Connelly Early P	Athletics WIN 4.8-4.5 by 0.3 Prediction	Athletics wins 2-1
6:45 PM	Atlanta Braves @ Washington Nationals Chris Sale vs MacKenzie Gore by 1.5 +/- Lineups Jurickson Profar LF Matt Olson 1B Ronald Acuna RF Ozzie Albies 2B Marcell Ozuna DH Michael Harris CF Sandy Leon C Nacho Alvarez 3B Nick Allen SS Chris Sale P Nasim Nunez SS Dylan Crews RF Josh Bell DH Daylen Lile LF Riley Adams C Andres Chaparro 1B Brady House 3B Paul DeJong 2B Jacob Young CF MacKenzie Gore P	Atlanta Braves WIN 4.0-2.8 by 1.2 Prediction	Atlanta Braves wins 5-0
7:10 PM	San Diego Padres @ New York Mets Michael King vs Sean Manaea by 1.5 +/- Lineups Fernando Tatis RF Luis Arraez 2B Manny Machado 3B Gavin Sheets DH Ramon Laureano LF Jackson Merrill CF Ryan O'Hearn 1B Jake Cronenworth SS Freddy Fermin C Michael King P Francisco Lindor SS Juan Soto RF Pete Alonso 1B Brandon Nimmo LF Mark Vientos DH Jeff McNeil 2B Brett Baty 3B Francisco Alvarez C Cedric Mullins CF Sean Manaea P	New York Mets WIN 3.7-3.2 by 0.4 Prediction	New York Mets wins 8-3
7:35 PM	Toronto Blue Jays @ Tampa Bay Rays Jose Berrios vs Ryan Pepiot by 1.5 +/- Lineups George Springer DH Nathan Lukes RF Vladimir Guerrero 1B Addison Barger 3B Alejandro Kirk C Davis Schneider LF Ernie Clement 2B Andres Gimenez SS Myles Straw CF Jose Berrios P Chandler Simpson LF Yandy Diaz DH Brandon Lowe 2B Junior Caminero 3B Josh Lowe RF Jake Mangum CF Tristan Gray SS Hunter Feduccia C Bob Seymour 1B Ryan Pepiot P	Toronto Blue Jays WIN 4.4-4.0 by 0.3 Prediction	Toronto Blue Jays wins 6-5
7:40 PM	Baltimore Orioles @ Chicago White Sox Dean Kremer vs Shane Smith by 1.5 +/- Lineups Jackson Holliday 2B Jeremiah Jackson 3B Gunnar Henderson SS Jordan Westburg DH Dylan Beavers RF Colton Cowser CF Coby Mayo 1B Samuel Basallo C Dylan Carlson LF Dean Kremer P Chase Meidroth 2B Kyle Teel C Colson Montgomery SS Miguel Vargas 3B Mike Tauchman RF Lenyn Sosa 1B Andrew Benintendi LF Edgar Quero DH Brooks Baldwin CF Shane Smith P	Chicago White Sox WIN 4.3-4.1 by 0.3 Prediction	Baltimore Orioles wins 8-7
7:40 PM	Seattle Mariners @ Kansas City Royals Logan Gilbert vs Michael Wacha by 1.5 +/- Lineups Randy Arozarena LF Cal Raleigh C Julio Rodriguez CF Josh Naylor 1B Jorge Polanco 2B Eugenio Suarez 3B Dominic Canzone DH Victor Robles RF J.P. Crawford SS Logan Gilbert P Mike Yastrzemski LF Bobby Witt SS Vinnie Pasquantino 1B Maikel Garcia 3B Salvador Perez DH Jac Caglianone RF Jonathan India 2B Carter Jensen C Kyle Isbel CF Michael Wacha P	Seattle Mariners WIN 5.2-4.2 by 1.1 Prediction	Seattle Mariners wins 12-5
7:40 PM	New York Yankees @ Minnesota Twins Cam Schlittler vs Zebby Matthews by 1.5 +/- Lineups Trent Grisham CF Aaron Judge RF Ben Rice 1B Cody Bellinger LF Giancarlo Stanton DH Jazz Chisholm 2B Ryan McMahon 3B Anthony Volpe SS Austin Wells C Cam Schlittler P Byron Buxton CF Austin Martin 2B Trevor Larnach DH Kody Clemens 1B Royce Lewis 3B Matt Wallner RF Mickey Gasper C Ryan Fitzgerald SS James Outman LF Zebby Matthews P	New York Yankees WIN 6.3-4.1 by 2.2 Prediction	New York Yankees wins 10-9
7:40 PM	Los Angeles Angels @ Milwaukee Brewers Caden Dana vs Freddy Peralta by 1.5 +/- Lineups Oswald Peraza 3B Mike Trout DH Taylor Ward LF Jo Adell RF Logan O'Hoppe C Christian Moore 2B Carter Kieboom 1B Denzer Guzman SS Bryce Teodosio CF Caden Dana P Sal Frelick RF Jackson Chourio LF Christian Yelich DH William Contreras C Brice Turang 2B Andrew Vaughn 1B Caleb Durbin 3B Blake Perkins CF Joey Ortiz SS Freddy Peralta P	Milwaukee Brewers WIN 4.4-3.5 by 1.0 Prediction	Milwaukee Brewers wins 9-2
7:45 PM	Cincinnati Reds @ St. Louis Cardinals Andrew Abbott vs Michael McGreevy by 1.5 +/- Lineups TJ Friedl CF Gavin Lux DH Noelvi Marte RF Sal Stewart 1B Will Benson LF Tyler Stephenson C Elly De La Cruz SS Ke'Bryan Hayes 3B Matt McLain 2B Andrew Abbott P Brendan Donovan 2B Ivan Herrera DH Nolan Arenado 3B Alec Burleson 1B Thomas Saggese SS Lars Nootbaar LF Pedro Pages C Jordan Walker RF Nathan Church CF Michael McGreevy P	Cincinnati Reds WIN 5.3-3.8 by 1.5 Prediction	St. Louis Cardinals wins 3-0
8:10 PM	Texas Rangers @ Houston Astros Merrill Kelly vs AJ Blubaugh by 1.5 +/- Lineups Josh Smith SS Wyatt Langford LF Jake Burger 1B Joc Pederson DH Kyle Higashioka C Josh Jung 3B Alejandro Osuna RF Michael Helman CF Cody Freeman 2B Merrill Kelly P Jeremy Pena SS Carlos Correa 3B Jose Altuve 2B Christian Walker 1B Zach Cole RF Jake Meyers CF Victor Caratini C Yainer Diaz DH Jesus Sanchez LF AJ Blubaugh P	Houston Astros WIN 4.0-3.2 by 0.8 Prediction	Houston Astros wins 6-5
8:40 PM	Miami Marlins @ Colorado Rockies Eury Perez vs Kyle Freeland by 1.5 +/- Lineups Otto Lopez SS Agustin Ramirez C Jakob Marsee CF Heriberto Hernandez DH Eric Wagaman 1B Connor Norby 3B Dane Myers LF Joey Wiemer RF Javier Sanoja 2B Eury Perez P Tyler Freeman DH Mickey Moniak RF Hunter Goodman C Jordan Beck LF Ezequiel Tovar SS Brenton Doyle CF Blaine Crim 1B Kyle Karros 3B Ryan Ritter 2B Kyle Freeland P	Miami Marlins WIN 4.4-3.7 by 0.7 Prediction	Miami Marlins wins 6-5
9:40 PM	San Francisco Giants @ Arizona Diamondbacks Tristan Beck vs Eduardo Rodriguez by 1.5 +/- Lineups Heliot Ramos LF Rafael Devers DH Willy Adames SS Matt Chapman 3B Wilmer Flores 1B Casey Schmitt 2B Jerar Encarnacion RF Jung Hoo Lee CF Andrew Knizner C Tristan Beck P Geraldo Perdomo SS Ketel Marte 2B Corbin Carroll RF Gabriel Moreno C Blaze Alexander 3B Adrian Del Castillo DH Alek Thomas CF Ildemaro Vargas 1B Jake McCarthy LF Eduardo Rodriguez P	Arizona Diamondbacks WIN 4.3-3.7 by 0.6 Prediction	Arizona Diamondbacks wins 6-5
10:10 PM	Philadelphia Phillies @ Los Angeles Dodgers Cristopher Sanchez vs Shohei Ohtani by 1.5 +/- Lineups Harrison Bader CF Kyle Schwarber DH Bryce Harper 1B Brandon Marsh LF Otto Kemp 3B Max Kepler RF Weston Wilson 2B Bryson Stott SS Rafael Marchan C Cristopher Sanchez P Shohei Ohtani DH Mookie Betts SS Teoscar Hernandez RF Freddie Freeman 1B Tommy Edman 2B Alex Call LF Andy Pages CF Enrique Hernandez 3B Ben Rortvedt C Shohei Ohtani P	Philadelphia Phillies WIN 4.9-4.6 by 0.3 Prediction	Philadelphia Phillies wins 9-6

Legend/Totals

Correct Picks	13 (81.3%)
Incorrect Picks	3 (18.8%)
Final Margin within 5 Runs	5 (31.3%)
Beat the Spread	10 (62.5%)

MLB Predictions for 9/16/2025

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