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Predictions refresh daily and may update during the day when key injuries or depth chart changes occur.

MLB Predictions for 9/14/2025

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Odds: Line | O/U | Money Line

9/14/2025 MLB Games
Time *ET	Matchup	Prediction	Actual	Result
11:35 AM	Pittsburgh Pirates @ Washington Nationals Mike Burrows vs Cade Cavalli by 1.5 +/- Lineups Jared Triolo 3B Spencer Horwitz 1B Bryan Reynolds DH Tommy Pham LF Nick Gonzales SS Oneil Cruz CF Joey Bart C Nick Yorke 2B Ji Hwan Bae RF Mike Burrows P CJ Abrams SS James Wood DH Riley Adams C Daylen Lile LF Andres Chaparro 1B Robert Hassell RF Paul DeJong 3B Nasim Nunez 2B Jacob Young CF Cade Cavalli P	Pittsburgh Pirates WIN 4.2-3.4 by 0.8 Prediction	Washington Nationals wins 4-3
1:35 PM	Kansas City Royals @ Philadelphia Phillies Noah Cameron vs Aaron Nola by 1.5 +/- Lineups Mike Yastrzemski CF Bobby Witt SS Vinnie Pasquantino 1B Maikel Garcia 3B Salvador Perez DH Michael Massey LF Jonathan India 2B Jac Caglianone RF Carter Jensen C Noah Cameron P Harrison Bader CF Kyle Schwarber DH Bryce Harper 1B J.T. Realmuto C Nick Castellanos RF Brandon Marsh LF Otto Kemp 3B Bryson Stott SS Weston Wilson 2B Aaron Nola P	Kansas City Royals WIN 4.9-3.7 by 1.2 Prediction	Kansas City Royals wins 10-3
1:35 PM	Houston Astros @ Atlanta Braves Framber Valdez vs Joey Wentz by 1.5 +/- Lineups Jeremy Pena SS Yordan Alvarez DH Carlos Correa 3B Christian Walker 1B Jake Meyers CF Yainer Diaz C Cam Smith RF Zach Cole LF Mauricio Dubon 2B Framber Valdez P Jurickson Profar LF Matt Olson 1B Ronald Acuna RF Ozzie Albies 2B Ha-Seong Kim SS Marcell Ozuna DH Michael Harris CF Sandy Leon C Nacho Alvarez 3B Joey Wentz P	Houston Astros WIN 4.5-4.0 by 0.4 Prediction	Atlanta Braves wins 8-3
1:37 PM	Baltimore Orioles @ Toronto Blue Jays Albert Suarez vs Shane Bieber by 1.5 +/- Lineups Jackson Holliday 2B Dylan Beavers RF Gunnar Henderson SS Jeremiah Jackson 3B Samuel Basallo DH Coby Mayo 1B Colton Cowser CF Dylan Carlson LF Alex Jackson C Albert Suarez P George Springer DH Davis Schneider LF Vladimir Guerrero 1B Addison Barger 3B Alejandro Kirk C Daulton Varsho CF Ernie Clement 2B Joey Loperfido RF Andres Gimenez SS Shane Bieber P	Toronto Blue Jays WIN 5.0-3.4 by 1.6 Prediction	Toronto Blue Jays wins 11-2
1:40 PM	Texas Rangers @ New York Mets Jacob Latz vs Nolan McLean by 1.5 +/- Lineups Josh Smith SS Wyatt Langford CF Joc Pederson DH Adolis Garcia RF Rowdy Tellez 1B Josh Jung 3B Alejandro Osuna LF Kyle Higashioka C Cody Freeman 2B Jacob Latz P Francisco Lindor SS Juan Soto RF Pete Alonso 1B Brandon Nimmo LF Mark Vientos 3B Jeff McNeil 2B Starling Marte DH Cedric Mullins CF Francisco Alvarez C Nolan McLean P	New York Mets WIN 4.0-3.2 by 0.8 Prediction	New York Mets wins 5-2
1:40 PM	Chicago White Sox @ Cleveland Guardians Yoendrys Gomez vs Slade Cecconi by 1.5 +/- Lineups Mike Tauchman RF Kyle Teel C Lenyn Sosa 1B Colson Montgomery SS Miguel Vargas 3B Andrew Benintendi DH Will Robertson LF Chase Meidroth 2B Dominic Fletcher CF Yoendrys Gomez P Steven Kwan LF Nolan Jones CF Jose Ramirez DH Kyle Manzardo 1B Bo Naylor C Gabriel Arias SS Daniel Schneemann 3B C.J. Kayfus RF Brayan Rocchio 2B Slade Cecconi P	Chicago White Sox WIN 4.1-4.0 by 0.2 Prediction	Cleveland Guardians wins 3-2
1:40 PM	Detroit Tigers @ Miami Marlins Jose Urquidy vs Adam Mazur by 1.5 +/- Lineups Parker Meadows CF Gleyber Torres 2B Kerry Carpenter LF Riley Greene DH Spencer Torkelson 1B Wenceel Perez RF Colt Keith 3B Dillon Dingler C Zach McKinstry SS Jose Urquidy P Otto Lopez SS Jakob Marsee CF Agustin Ramirez C Liam Hicks DH Eric Wagaman 1B Troy Johnston LF Maximo Acosta 2B Victor Mesa RF Javier Sanoja 3B Adam Mazur P	Detroit Tigers WIN 4.7-4.3 by 0.3 Prediction	Detroit Tigers wins 2-0
2:10 PM	Arizona Diamondbacks @ Minnesota Twins Nabil Crismatt vs Bailey Ober by 1.5 +/- Lineups Geraldo Perdomo SS Ketel Marte DH Corbin Carroll RF Blaze Alexander 2B Jordan Lawlar 3B Alek Thomas CF James McCann C Jorge Barrosa LF Tim Tawa 1B Nabil Crismatt P Byron Buxton CF Austin Martin LF Kody Clemens 1B Luke Keaschall 2B Matt Wallner RF Royce Lewis 3B Brooks Lee SS Mickey Gasper C Edouard Julien DH Bailey Ober P	Minnesota Twins WIN 5.0-4.1 by 0.9 Prediction	Arizona Diamondbacks wins 6-4
2:10 PM	St. Louis Cardinals @ Milwaukee Brewers Miles Mikolas vs Jose Quintana by 1.5 +/- Lineups Lars Nootbaar LF Ivan Herrera DH Alec Burleson 1B Thomas Saggese SS Nolan Gorman 3B Pedro Pages C Jordan Walker RF Jose Fermin 2B Nathan Church CF Miles Mikolas P Sal Frelick RF Jackson Chourio CF Christian Yelich DH Isaac Collins LF Brice Turang 2B Caleb Durbin 3B Jake Bauers 1B Danny Jansen C Andruw Monasterio SS Jose Quintana P	Milwaukee Brewers WIN 4.3-3.8 by 0.6 Prediction	St. Louis Cardinals wins 3-2
2:20 PM	Tampa Bay Rays @ Chicago Cubs Adrian Houser vs Shota Imanaga by 1.5 +/- Lineups Yandy Diaz DH Junior Caminero 3B Brandon Lowe 2B Christopher Morel LF Nick Fortes C Josh Lowe RF Everson Pereira CF Carson Williams SS Bob Seymour 1B Adrian Houser P Michael Busch 1B Nico Hoerner 2B Ian Happ LF Moises Ballesteros DH Dansby Swanson SS Pete Crow-Armstrong CF Willi Castro RF Reese McGuire C Matt Shaw 3B Shota Imanaga P	Chicago Cubs WIN 4.4-2.9 by 1.5 Prediction	Chicago Cubs wins 4-3
4:05 PM	Cincinnati Reds @ Athletics Nick Lodolo vs Luis Morales by 1.5 +/- Lineups TJ Friedl CF Noelvi Marte RF Elly De La Cruz SS Sal Stewart 1B Gavin Lux DH Will Benson LF Ke'Bryan Hayes 3B Jose Trevino C Matt McLain 2B Nick Lodolo P Shea Langeliers DH Jacob Wilson SS Nick Kurtz 1B Brent Rooker RF Colby Thomas CF Darell Hernaiz 2B Brett Harris 3B Willie MacIver C Max Schuemann LF Luis Morales P	Athletics WIN 4.9-4.0 by 0.9 Prediction	Athletics wins 7-4
4:05 PM	Los Angeles Dodgers @ San Francisco Giants Tyler Glasnow vs Robbie Ray by 1.5 +/- Lineups Shohei Ohtani DH Mookie Betts SS Teoscar Hernandez RF Freddie Freeman 1B Tommy Edman CF Alex Call LF Miguel Rojas 2B Enrique Hernandez 3B Ben Rortvedt C Tyler Glasnow P Heliot Ramos LF Rafael Devers DH Willy Adames SS Matt Chapman 3B Jung Hoo Lee CF Wilmer Flores 1B Patrick Bailey C Casey Schmitt 2B Drew Gilbert RF Robbie Ray P	Los Angeles Dodgers WIN 4.8-4.2 by 0.6 Prediction	Los Angeles Dodgers wins 10-2
4:10 PM	Colorado Rockies @ San Diego Padres German Marquez vs Yu Darvish by 1.5 +/- Lineups Tyler Freeman DH Ezequiel Tovar SS Mickey Moniak LF Blaine Crim 1B Brenton Doyle CF Yanquiel Fernandez RF Kyle Farmer 3B Braxton Fulford C Ryan Ritter 2B German Marquez P Fernando Tatis RF Jackson Merrill CF Ramon Laureano LF Gavin Sheets DH Ryan O'Hearn 1B Jake Cronenworth 2B Jose Iglesias 3B Freddy Fermin C Mason McCoy SS Yu Darvish P	San Diego Padres WIN 5.1-3.4 by 1.7 Prediction	San Diego Padres wins 9-6
4:10 PM	Los Angeles Angels @ Seattle Mariners Kyle Hendricks vs George Kirby by 1.5 +/- Lineups Mike Trout DH Yoan Moncada 3B Taylor Ward LF Jo Adell RF Christian Moore 2B Logan Davidson 1B Denzer Guzman SS Sebastian Rivero C Bryce Teodosio CF Kyle Hendricks P Randy Arozarena LF Cal Raleigh C Julio Rodriguez CF Josh Naylor 1B Jorge Polanco DH Eugenio Suarez 3B Dominic Canzone RF Leo Rivas 2B J.P. Crawford SS George Kirby P	Seattle Mariners WIN 4.9-4.2 by 0.7 Prediction	Seattle Mariners wins 11-2
7:10 PM	New York Yankees @ Boston Red Sox Will Warren vs Garrett Crochet by 1.5 +/- Lineups Austin Slater RF Aaron Judge DH Cody Bellinger CF Giancarlo Stanton LF Amed Rosario 3B Paul Goldschmidt 1B Jazz Chisholm 2B Jose Caballero SS Ben Rice C Will Warren P Jarren Duran LF Alex Bregman 3B Trevor Story SS Nathaniel Lowe 1B Romy Gonzalez 2B Masataka Yoshida DH Rob Refsnyder RF Carlos Narvaez C Ceddanne Rafaela CF Garrett Crochet P	New York Yankees WIN 5.0-4.3 by 0.7 Prediction	Boston Red Sox wins 6-4

Legend/Totals

Correct Picks	9 (60.0%)
Incorrect Picks	6 (40.0%)
Final Margin within 5 Runs	1 (6.7%)
Beat the Spread	9 (60.0%)

MLB Predictions for 9/14/2025

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