MLB Predictions & Baseball Game Simulator - MyGameSim.com

MLB Predictions for 9/17/2025


9/17/2025 MLB Games
Time *ETMatchupPredictionActualResult
12:35 PM Chicago Cubs @ Pittsburgh Pirates  
Matthew Boyd vs Johan Oviedo
by 1.5
+/- Lineups
Chicago Cubs
WIN 4.0-3.2
  by 0.8
Prediction
Chicago Cubs wins 8-4

1:15 PM Cincinnati Reds @ St. Louis Cardinals  
Brady Singer vs Andre Pallante
by 1.5
+/- Lineups
Cincinnati Reds
WIN 4.6-4.1
  by 0.5
Prediction
Cincinnati Reds wins 6-2

2:10 PM Baltimore Orioles @ Chicago White Sox  
Tyler Wells vs Martin Perez
by 1.5
+/- Lineups
Chicago White Sox
WIN 3.8-3.6
  by 0.2
Prediction
Baltimore Orioles wins 3-1

3:40 PM San Francisco Giants @ Arizona Diamondbacks  
Justin Verlander vs Brandon Pfaadt
by 1.5
+/- Lineups
Arizona Diamondbacks
WIN 4.6-4.6
  by 0.0
Prediction
San Francisco Giants wins 5-1

4:05 PM Atlanta Braves @ Washington Nationals  
Hurston Waldrep vs Brad Lord
by 1.5
+/- Lineups
Atlanta Braves
WIN 4.9-3.6
  by 1.3
Prediction
Atlanta Braves wins 9-4

6:40 PM Cleveland Guardians @ Detroit Tigers  
Gavin Williams vs Jack Flaherty
by 1.5
+/- Lineups
Detroit Tigers
WIN 4.2-3.9
  by 0.3
Prediction
Cleveland Guardians wins 4-0

 
6:45 PM Athletics @ Boston Red Sox  
Mason Barnett vs Lucas Giolito
by 1.5
+/- Lineups
Boston Red Sox
WIN 5.2-4.1
  by 1.1
Prediction
Boston Red Sox wins 5-4

 
 
7:05 PM Toronto Blue Jays @ Tampa Bay Rays  
Kevin Gausman vs Ian Seymour
by 1.5
+/- Lineups
Toronto Blue Jays
WIN 4.6-3.4
  by 1.2
Prediction
Tampa Bay Rays wins 2-1

 
7:10 PM San Diego Padres @ New York Mets  
Nick Pivetta vs David Peterson
by 1.5
+/- Lineups
New York Mets
WIN 3.8-3.5
  by 0.3
Prediction
San Diego Padres wins 7-4

 
7:40 PM Seattle Mariners @ Kansas City Royals  
Bryce Miller vs Cole Ragans
by 1.5
+/- Lineups
Seattle Mariners
WIN 5.3-5.0
  by 0.3
Prediction
Kansas City Royals wins 7-5

7:40 PM New York Yankees @ Minnesota Twins  
Luis Gil vs Taj Bradley
by 1.5
+/- Lineups
New York Yankees
WIN 5.6-4.4
  by 1.2
Prediction
New York Yankees wins 10-5

7:40 PM Los Angeles Angels @ Milwaukee Brewers  
Jose Soriano vs Brandon Woodruff
by 1.5
+/- Lineups
Milwaukee Brewers
WIN 4.4-3.5
  by 0.9
Prediction
Milwaukee Brewers wins 9-2

8:10 PM Texas Rangers @ Houston Astros  
Jacob deGrom vs Cristian Javier
by 1.5
+/- Lineups
Houston Astros
WIN 3.6-3.2
  by 0.4
Prediction
Houston Astros wins 5-2

 
8:40 PM Miami Marlins @ Colorado Rockies  
Ryan Weathers vs McCade Brown
by 1.5
+/- Lineups
Miami Marlins
WIN 6.1-4.0
  by 2.1
Prediction
Miami Marlins wins 8-4

 
10:10 PM Philadelphia Phillies @ Los Angeles Dodgers  
Jesus Luzardo vs Blake Snell
by 1.5
+/- Lineups
Los Angeles Dodgers
WIN 4.7-3.6
  by 1.0
Prediction
Los Angeles Dodgers wins 5-0

Legend/Totals

Correct Picks 9 (60.0%)
Incorrect Picks 6 (40.0%)
Final Margin within 5 Runs 1 (6.7%)
Beat the Spread 6 (40.0%)

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