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MLB Predictions for 8/22/2025

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Odds: Line | O/U | Money Line

8/22/2025 MLB Games
Time *ET	Matchup	Prediction	Actual	Result
6:40 PM	Colorado Rockies @ Pittsburgh Pirates Antonio Senzatela vs Braxton Ashcraft O/U 8.5 +/- Lineups Tyler Freeman DH Mickey Moniak CF Ezequiel Tovar SS Jordan Beck LF Kyle Karros 3B Braxton Fulford C Yanquiel Fernandez RF Orlando Arcia 1B Ryan Ritter 2B Antonio Senzatela P Spencer Horwitz 1B Nick Gonzales 2B Bryan Reynolds RF Tommy Pham LF Andrew McCutchen DH Jack Suwinski CF Jared Triolo SS Henry Davis C Isiah Kiner-Falefa 3B Braxton Ashcraft P	Pittsburgh Pirates WIN 4.7-3.7 by 1.0 Prediction	Pittsburgh Pirates wins 9-0
6:45 PM	Washington Nationals @ Philadelphia Phillies Cade Cavalli vs Taijuan Walker O/U 9 +/- Lineups James Wood LF CJ Abrams SS Josh Bell 1B Riley Adams C Luis Garcia 2B Dylan Crews RF Daylen Lile DH Brady House 3B Robert Hassell CF Cade Cavalli P Trea Turner SS Kyle Schwarber DH Bryce Harper 1B J.T. Realmuto C Alec Bohm 3B Brandon Marsh CF Nick Castellanos RF Max Kepler LF Bryson Stott 2B Taijuan Walker P	Philadelphia Phillies WIN 4.6-4.1 by 0.5 Prediction	Washington Nationals wins 5-4
7:05 PM	Houston Astros @ Baltimore Orioles Lance McCullers Jr. vs Cade Povich O/U 9.5 +/- Lineups Jeremy Pena SS Carlos Correa 3B Jose Altuve DH Christian Walker 1B Yainer Diaz C Ramon Urias 2B Mauricio Dubon LF Cam Smith RF Chas McCormick CF Lance McCullers Jr. P Jackson Holliday 2B Jeremiah Jackson RF Gunnar Henderson SS Ryan Mountcastle DH Colton Cowser CF Coby Mayo 1B Dylan Beavers LF Luis Vazquez 3B Alex Jackson C Cade Povich P	Houston Astros WIN 5.0-4.3 by 0.7 Prediction	Houston Astros wins 10-7
7:05 PM	Boston Red Sox @ New York Yankees Brayan Bello vs Max Fried O/U 8.5 +/- Lineups Romy Gonzalez 1B Alex Bregman 3B Roman Anthony RF Trevor Story SS Jhostynxon Garcia CF Jarren Duran LF Ceddanne Rafaela 2B Nate Eaton DH Connor Wong C Brayan Bello P Trent Grisham CF Ben Rice 1B Aaron Judge DH Cody Bellinger RF Jazz Chisholm 2B Jasson Dominguez LF Anthony Volpe SS Ryan McMahon 3B Austin Wells C Max Fried P	New York Yankees WIN 5.2-3.7 by 1.5 Prediction	Boston Red Sox wins 1-0
7:10 PM	Kansas City Royals @ Detroit Tigers Ryan Bergert vs Casey Mize O/U 8.5 +/- Lineups Mike Yastrzemski RF Bobby Witt SS Vinnie Pasquantino 1B Maikel Garcia 3B Salvador Perez C Adam Frazier 2B Jonathan India DH John Rave LF Kyle Isbel CF Ryan Bergert P Colt Keith 3B Gleyber Torres 2B Kerry Carpenter DH Riley Greene LF Spencer Torkelson 1B Wenceel Perez RF Dillon Dingler C Zach McKinstry SS Javier Baez CF Casey Mize P	Kansas City Royals WIN 4.1-3.9 by 0.2 Prediction	Detroit Tigers wins 7-5
7:10 PM	Toronto Blue Jays @ Miami Marlins Shane Bieber vs Ryan Gusto O/U 8 +/- Lineups George Springer DH Addison Barger RF Bo Bichette SS Alejandro Kirk C Daulton Varsho CF Ty France 1B Nathan Lukes LF Ernie Clement 3B Andres Gimenez 2B Shane Bieber P Xavier Edwards 2B Jakob Marsee RF Agustin Ramirez DH Otto Lopez SS Liam Hicks C Heriberto Hernandez LF Troy Johnston 1B Derek Hill CF Javier Sanoja 3B Ryan Gusto P	Toronto Blue Jays WIN 4.8-4.2 by 0.6 Prediction	Toronto Blue Jays wins 5-2
7:15 PM	New York Mets @ Atlanta Braves Nolan McLean vs Joey Wentz O/U 8.5 +/- Lineups Francisco Lindor SS Juan Soto RF Starling Marte DH Pete Alonso 1B Mark Vientos 3B Brett Baty 2B Tyrone Taylor LF Cedric Mullins CF Hayden Senger C Nolan McLean P Jurickson Profar LF Matt Olson 1B Ronald Acuna RF Michael Harris CF Marcell Ozuna DH Drake Baldwin C Ozzie Albies 2B Nacho Alvarez 3B Nick Allen SS Joey Wentz P	Atlanta Braves WIN 3.7-2.5 by 1.2 Prediction	New York Mets wins 12-7
7:35 PM	St. Louis Cardinals @ Tampa Bay Rays Miles Mikolas vs Adrian Houser O/U 9 +/- Lineups Lars Nootbaar CF Ivan Herrera DH Alec Burleson LF Willson Contreras 1B Nolan Gorman 3B Masyn Winn SS Thomas Saggese 2B Yohel Pozo C Jordan Walker RF Miles Mikolas P Chandler Simpson LF Junior Caminero 3B Brandon Lowe DH Josh Lowe RF Jake Mangum CF Hunter Feduccia C Carson Williams SS Bob Seymour 1B Tristan Gray 2B Adrian Houser P	St. Louis Cardinals WIN 5.6-4.4 by 1.3 Prediction	Tampa Bay Rays wins 10-6
7:40 PM	Minnesota Twins @ Chicago White Sox Zebby Matthews vs Aaron Civale O/U 8.5 +/- Lineups Byron Buxton CF Trevor Larnach DH Luke Keaschall 2B Matt Wallner RF Ryan Jeffers C Brooks Lee SS James Outman LF Royce Lewis 3B Edouard Julien 1B Zebby Matthews P Mike Tauchman RF Miguel Vargas 3B Kyle Teel C Lenyn Sosa 1B Colson Montgomery SS Luis Robert CF Andrew Benintendi LF Chase Meidroth 2B Edgar Quero DH Aaron Civale P	Chicago White Sox WIN 4.2-4.1 by 0.1 Prediction	Minnesota Twins wins 9-7
8:05 PM	Cleveland Guardians @ Texas Rangers Slade Cecconi vs Nathan Eovaldi O/U 7.5 +/- Lineups Steven Kwan LF Daniel Schneemann CF Jose Ramirez 3B Kyle Manzardo DH Carlos Santana 1B C.J. Kayfus RF Gabriel Arias SS Bo Naylor C Brayan Rocchio 2B Slade Cecconi P Josh Smith LF Wyatt Langford CF Corey Seager SS Joc Pederson DH Kyle Higashioka C Rowdy Tellez 1B Josh Jung 3B Ezequiel Duran 2B Alejandro Osuna RF Nathan Eovaldi P	Texas Rangers WIN 4.0-3.3 by 0.7 Prediction	Texas Rangers wins 4-3
8:10 PM	San Francisco Giants @ Milwaukee Brewers Carson Whisenhunt vs Jose Quintana O/U 9 +/- Lineups Heliot Ramos LF Rafael Devers 1B Willy Adames SS Wilmer Flores DH Casey Schmitt 3B Jung Hoo Lee CF Luis Matos RF Christian Koss 2B Patrick Bailey C Carson Whisenhunt P Brice Turang 2B William Contreras C Christian Yelich DH Andrew Vaughn 1B Sal Frelick RF Caleb Durbin 3B Isaac Collins LF Brandon Lockridge CF Andruw Monasterio SS Jose Quintana P	Milwaukee Brewers WIN 4.7-3.1 by 1.5 Prediction	Milwaukee Brewers wins 5-4
9:38 PM	Chicago Cubs @ Los Angeles Angels Javier Assad vs Tyler Anderson O/U 9.5 +/- Lineups Nico Hoerner 2B Kyle Tucker RF Seiya Suzuki DH Justin Turner 1B Carson Kelly C Ian Happ LF Pete Crow-Armstrong CF Dansby Swanson SS Matt Shaw 3B Javier Assad P Zach Neto SS Nolan Schanuel 1B Mike Trout DH Taylor Ward LF Yoan Moncada 3B Jo Adell RF Logan O'Hoppe C Christian Moore 2B Bryce Teodosio CF Tyler Anderson P	Los Angeles Angels WIN 5.4-5.3 by 0.1 Prediction	Chicago Cubs wins 3-2
9:40 PM	Cincinnati Reds @ Arizona Diamondbacks Zack Littell vs Ryne Nelson O/U 9 +/- Lineups TJ Friedl CF Gavin Lux DH Elly De La Cruz SS Austin Hays LF Noelvi Marte RF Spencer Steer 1B Ke'Bryan Hayes 3B Jose Trevino C Matt McLain 2B Zack Littell P Geraldo Perdomo SS Ketel Marte 2B Corbin Carroll RF Lourdes Gurriel LF Pavin Smith 1B Gabriel Moreno C Adrian Del Castillo DH Blaze Alexander 3B Alek Thomas CF Ryne Nelson P	Arizona Diamondbacks WIN 4.1-3.9 by 0.1 Prediction	Arizona Diamondbacks wins 6-5
9:40 PM	Los Angeles Dodgers @ San Diego Padres Blake Snell vs Yu Darvish O/U 8.5 +/- Lineups Shohei Ohtani DH Mookie Betts SS Will Smith C Freddie Freeman 1B Teoscar Hernandez RF Michael Conforto LF Andy Pages CF Alex Freeland 2B Buddy Kennedy 3B Blake Snell P Fernando Tatis RF Luis Arraez 1B Manny Machado 3B Ryan O'Hearn DH Xander Bogaerts SS Gavin Sheets LF Ramon Laureano CF Jake Cronenworth 2B Freddy Fermin C Yu Darvish P	San Diego Padres WIN 4.6-4.6 by 0.0 Prediction	San Diego Padres wins 2-1
10:10 PM	Athletics @ Seattle Mariners Luis Morales vs Bryan Woo O/U 8.5 +/- Lineups Nick Kurtz 1B Shea Langeliers C Brent Rooker DH Tyler Soderstrom LF Jacob Wilson SS Lawrence Butler CF Darell Hernaiz 2B JJ Bleday RF Brett Harris 3B Luis Morales P Randy Arozarena LF Cal Raleigh C Julio Rodriguez CF Josh Naylor 1B Eugenio Suarez 3B Jorge Polanco DH Luke Raley RF J.P. Crawford SS Cole Young 2B Bryan Woo P	Seattle Mariners WIN 4.8-3.9 by 0.9 Prediction	Seattle Mariners wins 3-2

Legend/Totals

Correct Picks	8 (53.3%)
Incorrect Picks	7 (46.7%)
Final Margin within 5 Runs	5 (33.3%)
Beat the Spread	2 (13.3%)

MLB Predictions for 8/22/2025

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