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MLB Predictions for 9/17/2025


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Odds: Line |  O/U |  Money Line

9/17/2025 MLB Games
Time *ETMatchupPredictionActualResult
12:35 PM Chicago Cubs @ Pittsburgh Pirates  
Matthew Boyd vs Johan Oviedo
O/U 7.5
+/- Lineups		Chicago Cubs
WIN 4.0-3.2
  by 0.8
Prediction
Chicago Cubs wins 8-4

1:15 PM Cincinnati Reds @ St. Louis Cardinals  
Brady Singer vs Andre Pallante
O/U 8.5
+/- Lineups		Cincinnati Reds
WIN 4.6-4.1
  by 0.5
Prediction
Cincinnati Reds wins 6-2

2:10 PM Baltimore Orioles @ Chicago White Sox  
Tyler Wells vs Martin Perez
O/U 8.5
+/- Lineups		Chicago White Sox
WIN 3.8-3.6
  by 0.2
Prediction
Baltimore Orioles wins 3-1

 
3:40 PM San Francisco Giants @ Arizona Diamondbacks  
Justin Verlander vs Brandon Pfaadt
O/U 9
+/- Lineups		Arizona Diamondbacks
WIN 4.6-4.6
  by 0.0
Prediction
San Francisco Giants wins 5-1

4:05 PM Atlanta Braves @ Washington Nationals  
Hurston Waldrep vs Brad Lord
O/U 8.5
+/- Lineups		Atlanta Braves
WIN 4.9-3.6
  by 1.3
Prediction
Atlanta Braves wins 9-4

6:40 PM Cleveland Guardians @ Detroit Tigers  
Gavin Williams vs Jack Flaherty
O/U 8
+/- Lineups		Detroit Tigers
WIN 4.2-3.9
  by 0.3
Prediction
Cleveland Guardians wins 4-0

6:45 PM Athletics @ Boston Red Sox  
Mason Barnett vs Lucas Giolito
O/U 9
+/- Lineups		Boston Red Sox
WIN 5.2-4.1
  by 1.1
Prediction
Boston Red Sox wins 5-4

 
7:05 PM Toronto Blue Jays @ Tampa Bay Rays  
Kevin Gausman vs Ian Seymour
O/U 7.5
+/- Lineups		Toronto Blue Jays
WIN 4.6-3.4
  by 1.2
Prediction
Tampa Bay Rays wins 2-1

7:10 PM San Diego Padres @ New York Mets  
Nick Pivetta vs David Peterson
O/U 7.5
+/- Lineups		New York Mets
WIN 3.8-3.5
  by 0.3
Prediction
San Diego Padres wins 7-4

7:40 PM Seattle Mariners @ Kansas City Royals  
Bryce Miller vs Cole Ragans
O/U 8.5
+/- Lineups		Seattle Mariners
WIN 5.3-5.0
  by 0.3
Prediction
Kansas City Royals wins 7-5

 
7:40 PM New York Yankees @ Minnesota Twins  
Luis Gil vs Taj Bradley
O/U 9.5
+/- Lineups		New York Yankees
WIN 5.6-4.4
  by 1.2
Prediction
New York Yankees wins 10-5

 
7:40 PM Los Angeles Angels @ Milwaukee Brewers  
Jose Soriano vs Brandon Woodruff
O/U 7.5
+/- Lineups		Milwaukee Brewers
WIN 4.4-3.5
  by 0.9
Prediction
Milwaukee Brewers wins 9-2

 
8:10 PM Texas Rangers @ Houston Astros  
Jacob deGrom vs Cristian Javier
O/U 7.5
+/- Lineups		Houston Astros
WIN 3.6-3.2
  by 0.4
Prediction
Houston Astros wins 5-2

 
8:40 PM Miami Marlins @ Colorado Rockies  
Ryan Weathers vs McCade Brown
O/U 10.5
+/- Lineups		Miami Marlins
WIN 6.1-4.0
  by 2.1
Prediction
Miami Marlins wins 8-4

10:10 PM Philadelphia Phillies @ Los Angeles Dodgers  
Jesus Luzardo vs Blake Snell
O/U 7.5
+/- Lineups		Los Angeles Dodgers
WIN 4.7-3.6
  by 1.0
Prediction
Los Angeles Dodgers wins 5-0

Legend/Totals

Correct Picks 9 (60.0%)
Incorrect Picks 6 (40.0%)
Final Margin within 5 Runs 1 (6.7%)
Beat the Spread 5 (33.3%)
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