How does the MLB Game Simulator work?

The MLB Game Simulator uses at-bat-by-at-bat modeling, pitcher data, and player stats to predict outcomes, scores, and performances.

Are MLB predictions updated daily?

Yes. Baseball predictions and player stat projections are updated daily to reflect pitching matchups, lineups, and recent performance.

How accurate are the MLB predictions?

Accuracy varies by day and matchup. We publish performance summaries so you can track results over time.

How often are predictions refreshed?

Predictions refresh daily and may update during the day when key injuries or depth chart changes occur.

MLB Predictions for 9/21/2025

<< Prev Next >>

Odds: Line | O/U | Money Line

9/21/2025 MLB Games
Time *ET	Matchup	Prediction	Actual	Result
1:10 PM	Atlanta Braves @ Detroit Tigers Spencer Strider vs Casey Mize O/U 8.5 +/- Lineups Jurickson Profar LF Matt Olson 1B Ronald Acuna RF Drake Baldwin C Ozzie Albies 2B Ha-Seong Kim SS Marcell Ozuna DH Michael Harris CF Vidal Brujan 3B Spencer Strider P Parker Meadows CF Gleyber Torres 2B Kerry Carpenter DH Riley Greene LF Spencer Torkelson 1B Wenceel Perez RF Dillon Dingler C Zach McKinstry 3B Javier Baez SS Casey Mize P	Atlanta Braves WIN 4.8-4.3 by 0.5 Prediction	Atlanta Braves wins 6-2
1:35 PM	Athletics @ Pittsburgh Pirates Mitch Spence vs Mike Burrows O/U 8.5 +/- Lineups Lawrence Butler CF Brent Rooker DH Nick Kurtz 1B Tyler Soderstrom LF Jacob Wilson SS Carlos Cortes RF Darell Hernaiz 3B Willie MacIver C Max Schuemann 2B Mitch Spence P Oneil Cruz CF Jared Triolo 3B Bryan Reynolds RF Spencer Horwitz 1B Andrew McCutchen DH Nick Gonzales SS Jack Suwinski LF Joey Bart C Nick Yorke 2B Mike Burrows P	Athletics WIN 4.4-3.8 by 0.6 Prediction	Pittsburgh Pirates wins 11-0
1:35 PM	New York Yankees @ Baltimore Orioles Cam Schlittler vs Kyle Bradish O/U 8.5 +/- Lineups Trent Grisham CF Aaron Judge DH Cody Bellinger RF Ben Rice 1B Jasson Dominguez LF Jazz Chisholm 2B Jose Caballero SS Austin Wells C Ryan McMahon 3B Cam Schlittler P Jackson Holliday 2B Dylan Beavers RF Gunnar Henderson SS Ryan Mountcastle DH Samuel Basallo C Jeremiah Jackson 3B Colton Cowser CF Coby Mayo 1B Dylan Carlson LF Kyle Bradish P	New York Yankees WIN 4.9-4.3 by 0.6 Prediction	New York Yankees wins 7-1
1:40 PM	Washington Nationals @ New York Mets Jake Irvin vs Clay Holmes O/U 8.5 +/- Lineups James Wood DH Dylan Crews RF Josh Bell 1B Daylen Lile LF Paul DeJong 2B Jorge Alfaro C Brady House 3B Nasim Nunez SS Jacob Young CF Jake Irvin P Francisco Lindor SS Juan Soto RF Brandon Nimmo LF Pete Alonso 1B Jeff McNeil 2B Mark Vientos DH Brett Baty 3B Luis Torrens C Cedric Mullins CF Clay Holmes P	New York Mets WIN 4.5-3.2 by 1.2 Prediction	Washington Nationals wins 3-2
1:40 PM	Chicago Cubs @ Cincinnati Reds Jameson Taillon vs Andrew Abbott O/U 9 +/- Lineups Nico Hoerner 2B Ian Happ LF Seiya Suzuki RF Carson Kelly C Carlos Santana DH Dansby Swanson SS Justin Turner 3B Michael Busch 1B Kevin Alcantara CF Jameson Taillon P TJ Friedl CF Gavin Lux DH Noelvi Marte RF Spencer Steer 1B Will Benson LF Elly De La Cruz SS Ke'Bryan Hayes 3B Jose Trevino C Matt McLain 2B Andrew Abbott P	Cincinnati Reds WIN 4.4-4.3 by 0.2 Prediction	Cincinnati Reds wins 1-0
1:40 PM	Atlanta Braves @ Detroit Tigers Spencer Strider vs Casey Mize O/U 8.5 +/- Lineups Jurickson Profar LF Matt Olson 1B Ronald Acuna RF Drake Baldwin C Ozzie Albies 2B Ha-Seong Kim SS Marcell Ozuna DH Michael Harris CF Vidal Brujan 3B Spencer Strider P Parker Meadows CF Gleyber Torres 2B Kerry Carpenter DH Riley Greene LF Spencer Torkelson 1B Wenceel Perez RF Dillon Dingler C Zach McKinstry 3B Javier Baez SS Casey Mize P	Atlanta Braves WIN 4.9-4.5 by 0.4 Prediction \| Simulate
2:10 PM	San Diego Padres @ Chicago White Sox Michael King vs Sean Burke O/U 8 +/- Lineups Fernando Tatis RF Luis Arraez 2B Manny Machado 3B Jackson Merrill CF Ramon Laureano LF Gavin Sheets DH Ryan O'Hearn 1B Jake Cronenworth SS Elias Diaz C Michael King P Chase Meidroth 2B Kyle Teel DH Colson Montgomery SS Miguel Vargas 3B Edgar Quero C Brooks Baldwin CF Lenyn Sosa 1B Will Robertson LF Dominic Fletcher RF Sean Burke P	San Diego Padres WIN 4.8-3.4 by 1.5 Prediction	San Diego Padres wins 3-2
2:10 PM	Toronto Blue Jays @ Kansas City Royals Trey Yesavage vs Michael Wacha O/U 8.5 +/- Lineups George Springer DH Daulton Varsho CF Vladimir Guerrero 1B Addison Barger 3B Davis Schneider LF Nathan Lukes RF Ernie Clement 2B Andres Gimenez SS Tyler Heineman C Trey Yesavage P Mike Yastrzemski LF Bobby Witt SS Vinnie Pasquantino 1B Maikel Garcia 3B Salvador Perez DH Adam Frazier 2B Carter Jensen C Jac Caglianone RF John Rave CF Michael Wacha P	Toronto Blue Jays WIN 5.4-3.6 by 1.9 Prediction	Toronto Blue Jays wins 8-5
2:10 PM	Cleveland Guardians @ Minnesota Twins Joey Cantillo vs Simeon Woods Richardson O/U 8.5 +/- Lineups Steven Kwan LF George Valera DH Jose Ramirez 3B Kyle Manzardo 1B Bo Naylor C Gabriel Arias SS Angel Martinez CF C.J. Kayfus RF Brayan Rocchio 2B Joey Cantillo P Byron Buxton CF Kody Clemens 2B Austin Martin LF Trevor Larnach RF Luke Keaschall DH Edouard Julien 1B Brooks Lee SS Jhonny Pereda C Ryan Fitzgerald 3B Simeon Woods Richardson P	Cleveland Guardians WIN 4.3-3.8 by 0.5 Prediction	Minnesota Twins wins 6-2
2:15 PM	Milwaukee Brewers @ St. Louis Cardinals Erick Fedde vs Matthew Liberatore O/U 8.5 +/- Lineups Jackson Chourio RF Isaac Collins LF Andrew Vaughn 1B Rhys Hoskins DH Caleb Durbin 3B Andruw Monasterio 2B Danny Jansen C Blake Perkins CF Joey Ortiz SS Erick Fedde P Thomas Saggese SS Ivan Herrera DH Alec Burleson 1B Lars Nootbaar LF Jordan Walker RF Nolan Gorman 3B Jose Fermin 2B Jimmy Crooks C Victor Scott CF Matthew Liberatore P	Milwaukee Brewers WIN 5.9-4.8 by 1.2 Prediction	St. Louis Cardinals wins 5-1
2:35 PM	Miami Marlins @ Texas Rangers Eury Perez vs Merrill Kelly O/U 7.5 +/- Lineups Jakob Marsee CF Agustin Ramirez DH Xavier Edwards 2B Liam Hicks 1B Otto Lopez SS Troy Johnston RF Heriberto Hernandez LF Graham Pauley 3B Brian Navarreto C Eury Perez P Joc Pederson DH Wyatt Langford LF Alejandro Osuna RF Rowdy Tellez 1B Josh Jung 3B Cody Freeman 2B Jonah Heim C Ezequiel Duran SS Michael Helman CF Merrill Kelly P	Miami Marlins WIN 4.3-3.2 by 1.1 Prediction	Miami Marlins wins 4-2
3:10 PM	Los Angeles Angels @ Colorado Rockies Caden Dana vs Kyle Freeland O/U 11.5 +/- Lineups Mike Trout DH Taylor Ward LF Jo Adell RF Nolan Schanuel 1B Logan O'Hoppe C Christian Moore 2B Oswald Peraza 3B Denzer Guzman SS Bryce Teodosio CF Caden Dana P Mickey Moniak RF Ezequiel Tovar SS Hunter Goodman DH Blaine Crim 1B Jordan Beck LF Brenton Doyle CF Kyle Karros 3B Braxton Fulford C Ryan Ritter 2B Kyle Freeland P	Los Angeles Angels WIN 5.1-5.0 by 0.1 Prediction	Colorado Rockies wins 3-1
4:10 PM	Philadelphia Phillies @ Arizona Diamondbacks Ranger Suarez vs Eduardo Rodriguez O/U 8.5 +/- Lineups Harrison Bader CF Kyle Schwarber DH Bryce Harper 1B J.T. Realmuto C Alec Bohm 3B Nick Castellanos RF Otto Kemp 2B Bryson Stott SS Weston Wilson LF Ranger Suarez P Ketel Marte 2B Geraldo Perdomo SS Corbin Carroll RF Gabriel Moreno C Blaze Alexander 3B Ildemaro Vargas 1B Tim Tawa LF Jordan Lawlar DH Jorge Barrosa CF Eduardo Rodriguez P	Philadelphia Phillies WIN 4.1-3.4 by 0.8 Prediction	Arizona Diamondbacks wins 9-2
4:10 PM	San Francisco Giants @ Los Angeles Dodgers Trevor McDonald vs Emmet Sheehan O/U 9 +/- Lineups Heliot Ramos LF Rafael Devers DH Willy Adames SS Matt Chapman 3B Bryce Eldridge 1B Jung Hoo Lee CF Christian Koss 2B Drew Gilbert RF Andrew Knizner C Trevor McDonald P Shohei Ohtani DH Mookie Betts SS Freddie Freeman 1B Max Muncy 3B Andy Pages CF Michael Conforto LF Miguel Rojas 2B Alex Call RF Dalton Rushing C Emmet Sheehan P	Los Angeles Dodgers WIN 5.6-3.7 by 1.9 Prediction	San Francisco Giants wins 3-1
7:10 PM	Seattle Mariners @ Houston Astros Logan Gilbert vs Jason Alexander O/U 8.5 +/- Lineups Randy Arozarena LF Cal Raleigh C Julio Rodriguez CF Josh Naylor 1B Jorge Polanco 2B Eugenio Suarez 3B Dominic Canzone DH Victor Robles RF J.P. Crawford SS Logan Gilbert P Jeremy Pena SS Carlos Correa 3B Isaac Paredes DH Jose Altuve 2B Christian Walker 1B Jesus Sanchez RF Yainer Diaz C Jake Meyers CF Mauricio Dubon LF Jason Alexander P	Seattle Mariners WIN 4.3-3.7 by 0.6 Prediction	Seattle Mariners wins 7-3
7:35 PM	Boston Red Sox @ Tampa Bay Rays Connelly Early vs Joe Boyle O/U 7.5 +/- Lineups Jarren Duran LF Trevor Story SS Alex Bregman 3B Masataka Yoshida RF Romy Gonzalez 2B Nathaniel Lowe 1B Ceddanne Rafaela CF Wilyer Abreu DH Connor Wong C Connelly Early P Chandler Simpson CF Yandy Diaz DH Junior Caminero 3B Brandon Lowe 2B Christopher Morel LF Nick Fortes C Tristan Gray 1B Everson Pereira RF Carson Williams SS Joe Boyle P	Boston Red Sox WIN 4.3-3.9 by 0.4 Prediction	Tampa Bay Rays wins 7-3

Legend/Totals

Correct Picks	7 (46.7%)
Incorrect Picks	8 (53.3%)
Final Margin within 5 Runs	3 (20.0%)
Beat the Spread	6 (40.0%)

MLB Predictions for 9/21/2025

Submit Feedback