MLB Predictions & Baseball Game Simulator - MyGameSim.com

MLB Predictions for 9/23/2025


9/23/2025 MLB Games
Time *ETMatchupPredictionActualResult
6:35 PM Tampa Bay Rays @ Baltimore Orioles  
Ryan Pepiot vs Dean Kremer
O/U 8.5
+/- Lineups
Baltimore Orioles
WIN 4.7-4.4
  by 0.3
Prediction
Baltimore Orioles wins 6-0

6:40 PM Detroit Tigers @ Cleveland Guardians  
Tarik Skubal vs Gavin Williams
O/U 6.5
+/- Lineups
Detroit Tigers
WIN 4.1-3.2
  by 0.9
Prediction
Cleveland Guardians wins 5-2

 
6:40 PM Pittsburgh Pirates @ Cincinnati Reds  
Johan Oviedo vs Brady Singer
O/U 8
+/- Lineups
Cincinnati Reds
WIN 4.2-3.6
  by 0.6
Prediction
Pittsburgh Pirates wins 4-2

 
6:45 PM Miami Marlins @ Philadelphia Phillies  
Edward Cabrera vs Cristopher Sanchez
O/U 7.5
+/- Lineups
Philadelphia Phillies
WIN 5.1-4.5
  by 0.6
Prediction
Miami Marlins wins 6-5

 
7:05 PM Chicago White Sox @ New York Yankees  
Shane Smith vs Luis Gil
O/U 9
+/- Lineups
New York Yankees
WIN 5.1-3.5
  by 1.5
Prediction
New York Yankees wins 3-2

 
 
7:07 PM Boston Red Sox @ Toronto Blue Jays  
Lucas Giolito vs Kevin Gausman
O/U 8
+/- Lineups
Toronto Blue Jays
WIN 4.7-4.0
  by 0.7
Prediction
Boston Red Sox wins 4-1

7:15 PM Washington Nationals @ Atlanta Braves  
Brad Lord vs Hurston Waldrep
O/U 9
+/- Lineups
Atlanta Braves
WIN 5.0-3.5
  by 1.5
Prediction
Atlanta Braves wins 3-2

 
 
7:40 PM New York Mets @ Chicago Cubs  
David Peterson vs Cade Horton
O/U 7.5
+/- Lineups
New York Mets
WIN 3.9-3.9
  by 0.0
Prediction
New York Mets wins 9-7

 
8:05 PM Minnesota Twins @ Texas Rangers  
Zebby Matthews vs Patrick Corbin
O/U 8
+/- Lineups
Texas Rangers
WIN 4.2-3.5
  by 0.7
Prediction
Minnesota Twins wins 4-1

 
9:38 PM Kansas City Royals @ Los Angeles Angels  
Cole Ragans vs Sam Aldegheri
O/U 9
+/- Lineups
Kansas City Royals
WIN 5.1-4.8
  by 0.4
Prediction
Kansas City Royals wins 8-4

 
9:40 PM Los Angeles Dodgers @ Arizona Diamondbacks  
Shohei Ohtani vs Brandon Pfaadt
O/U 9
+/- Lineups
Los Angeles Dodgers
WIN 5.1-4.2
  by 0.9
Prediction
Arizona Diamondbacks wins 5-4

9:40 PM Colorado Rockies @ Seattle Mariners  
McCade Brown vs Bryce Miller
O/U 8
+/- Lineups
Seattle Mariners
WIN 5.5-4.4
  by 1.1
Prediction
Seattle Mariners wins 4-3

 
9:40 PM Milwaukee Brewers @ San Diego Padres  
Bruce Zimmermann vs Randy Vasquez
O/U 8
+/- Lineups
Milwaukee Brewers
WIN 4.2-4.2
  by 0.0
Prediction
San Diego Padres wins 7-0

9:45 PM St. Louis Cardinals @ San Francisco Giants  
Andre Pallante vs Logan Webb
O/U 7.5
+/- Lineups
San Francisco Giants
WIN 4.9-3.8
  by 1.0
Prediction
St. Louis Cardinals wins 9-8

 
10:05 PM Houston Astros @ Athletics  
Cristian Javier vs Jeffrey Springs
O/U 10
+/- Lineups
Athletics
WIN 4.8-4.7
  by 0.1
Prediction
Athletics wins 5-1

 

Legend/Totals

Correct Picks 7 (46.7%)
Incorrect Picks 8 (53.3%)
Final Margin within 5 Runs 3 (20.0%)
Beat the Spread 10 (66.7%)

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