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Yes. Baseball predictions and player stat projections are updated daily to reflect pitching matchups, lineups, and recent performance.

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Predictions refresh daily and may update during the day when key injuries or depth chart changes occur.

MLB Predictions for 9/23/2025

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Odds: Line | O/U | Money Line

9/23/2025 MLB Games
Time *ET	Matchup	Prediction	Actual	Result
6:35 PM	Tampa Bay Rays @ Baltimore Orioles Ryan Pepiot vs Dean Kremer O/U 8.5 +/- Lineups Chandler Simpson CF Yandy Diaz DH Brandon Lowe 2B Junior Caminero 3B Josh Lowe RF Jake Mangum LF Hunter Feduccia C Carson Williams SS Bob Seymour 1B Ryan Pepiot P Jackson Holliday 2B Jordan Westburg 3B Gunnar Henderson SS Tyler O'Neill RF Dylan Beavers LF Adley Rutschman C Samuel Basallo DH Colton Cowser CF Coby Mayo 1B Dean Kremer P	Baltimore Orioles WIN 4.7-4.4 by 0.3 Prediction	Baltimore Orioles wins 6-0
6:40 PM	Detroit Tigers @ Cleveland Guardians Tarik Skubal vs Gavin Williams O/U 6.5 +/- Lineups Parker Meadows CF Gleyber Torres 2B Kerry Carpenter DH Spencer Torkelson 1B Riley Greene LF Dillon Dingler C Wenceel Perez RF Zach McKinstry 3B Javier Baez SS Tarik Skubal P Steven Kwan LF Angel Martinez CF Jose Ramirez 3B David Fry DH Gabriel Arias SS Kyle Manzardo 1B Jhonkensy Noel RF Brayan Rocchio 2B Austin Hedges C Gavin Williams P	Detroit Tigers WIN 4.1-3.2 by 0.9 Prediction	Cleveland Guardians wins 5-2
6:40 PM	Pittsburgh Pirates @ Cincinnati Reds Johan Oviedo vs Brady Singer O/U 8 +/- Lineups Oneil Cruz CF Jared Triolo 3B Bryan Reynolds RF Spencer Horwitz 1B Nick Gonzales SS Joey Bart DH Jack Suwinski LF Rafael Flores C Nick Yorke 2B Johan Oviedo P TJ Friedl CF Noelvi Marte RF Gavin Lux DH Spencer Steer 1B Elly De La Cruz SS Matt McLain 2B Will Benson LF Jose Trevino C Ke'Bryan Hayes 3B Brady Singer P	Cincinnati Reds WIN 4.2-3.6 by 0.6 Prediction	Pittsburgh Pirates wins 4-2
6:45 PM	Miami Marlins @ Philadelphia Phillies Edward Cabrera vs Cristopher Sanchez O/U 7.5 +/- Lineups Otto Lopez SS Agustin Ramirez C Jakob Marsee CF Connor Norby 3B Heriberto Hernandez DH Xavier Edwards 2B Eric Wagaman 1B Griffin Conine LF Dane Myers RF Edward Cabrera P Harrison Bader CF Kyle Schwarber DH Alec Bohm 3B Brandon Marsh LF J.T. Realmuto C Max Kepler RF Weston Wilson 2B Bryson Stott SS Otto Kemp 1B Cristopher Sanchez P	Philadelphia Phillies WIN 5.1-4.5 by 0.6 Prediction	Miami Marlins wins 6-5
7:05 PM	Chicago White Sox @ New York Yankees Shane Smith vs Luis Gil O/U 9 +/- Lineups Chase Meidroth 2B Kyle Teel C Colson Montgomery SS Miguel Vargas 3B Edgar Quero DH Brooks Baldwin CF Lenyn Sosa 1B Will Robertson LF Dominic Fletcher RF Shane Smith P Trent Grisham CF Aaron Judge RF Cody Bellinger LF Ben Rice 1B Giancarlo Stanton DH Jazz Chisholm 2B Ryan McMahon 3B Anthony Volpe SS Austin Wells C Luis Gil P	New York Yankees WIN 5.1-3.5 by 1.5 Prediction	New York Yankees wins 3-2
7:07 PM	Boston Red Sox @ Toronto Blue Jays Lucas Giolito vs Kevin Gausman O/U 8 +/- Lineups Jarren Duran LF Trevor Story SS Alex Bregman 3B Masataka Yoshida DH Romy Gonzalez 2B Ceddanne Rafaela CF Nathaniel Lowe 1B Wilyer Abreu RF Carlos Narvaez C Lucas Giolito P George Springer DH Daulton Varsho CF Vladimir Guerrero 1B Addison Barger 3B Alejandro Kirk C Nathan Lukes RF Davis Schneider LF Andres Gimenez SS Ernie Clement 2B Kevin Gausman P	Toronto Blue Jays WIN 4.7-4.0 by 0.7 Prediction	Boston Red Sox wins 4-1
7:15 PM	Washington Nationals @ Atlanta Braves Brad Lord vs Hurston Waldrep O/U 9 +/- Lineups Nasim Nunez 2B James Wood LF CJ Abrams SS Daylen Lile DH Luis Garcia 1B Dylan Crews RF Riley Adams C Brady House 3B Jacob Young CF Brad Lord P Jurickson Profar LF Matt Olson 1B Ronald Acuna RF Drake Baldwin C Ha-Seong Kim SS Michael Harris CF Marcell Ozuna DH Brett Wisely 2B Nacho Alvarez 3B Hurston Waldrep P	Atlanta Braves WIN 5.0-3.5 by 1.5 Prediction	Atlanta Braves wins 3-2
7:40 PM	New York Mets @ Chicago Cubs David Peterson vs Cade Horton O/U 7.5 +/- Lineups Francisco Lindor SS Juan Soto RF Pete Alonso 1B Brandon Nimmo CF Mark Vientos DH Brett Baty 3B Starling Marte LF Jeff McNeil 2B Francisco Alvarez C David Peterson P Nico Hoerner 2B Ian Happ LF Seiya Suzuki RF Carson Kelly C Carlos Santana 1B Dansby Swanson SS Justin Turner DH Matt Shaw 3B Pete Crow-Armstrong CF Cade Horton P	New York Mets WIN 3.9-3.9 by 0.0 Prediction	New York Mets wins 9-7
8:05 PM	Minnesota Twins @ Texas Rangers Zebby Matthews vs Patrick Corbin O/U 8 +/- Lineups Byron Buxton CF Austin Martin LF Ryan Jeffers DH Luke Keaschall 2B Royce Lewis 3B Carson McCusker RF Brooks Lee SS Kody Clemens 1B Christian Vazquez C Zebby Matthews P Joc Pederson DH Wyatt Langford CF Josh Smith SS Jake Burger 1B Adolis Garcia RF Alejandro Osuna LF Josh Jung 3B Kyle Higashioka C Cody Freeman 2B Patrick Corbin P	Texas Rangers WIN 4.2-3.5 by 0.7 Prediction	Minnesota Twins wins 4-1
9:38 PM	Kansas City Royals @ Los Angeles Angels Cole Ragans vs Sam Aldegheri O/U 9 +/- Lineups Maikel Garcia 3B Bobby Witt SS Vinnie Pasquantino 1B Salvador Perez C Mike Yastrzemski RF Randal Grichuk LF Adam Frazier 2B Carter Jensen DH Tyler Tolbert CF Cole Ragans P Mike Trout DH Nolan Schanuel 1B Taylor Ward LF Jo Adell RF Logan O'Hoppe C Oswald Peraza 3B Christian Moore 2B Denzer Guzman SS Bryce Teodosio CF Sam Aldegheri P	Kansas City Royals WIN 5.1-4.8 by 0.4 Prediction	Kansas City Royals wins 8-4
9:40 PM	Los Angeles Dodgers @ Arizona Diamondbacks Shohei Ohtani vs Brandon Pfaadt O/U 9 +/- Lineups Shohei Ohtani DH Mookie Betts SS Freddie Freeman 1B Max Muncy 3B Teoscar Hernandez RF Michael Conforto LF Tommy Edman 2B Andy Pages CF Ben Rortvedt C Shohei Ohtani P Geraldo Perdomo SS Ketel Marte 2B Corbin Carroll RF Gabriel Moreno DH Blaze Alexander 3B Ildemaro Vargas 1B Alek Thomas CF James McCann C Jake McCarthy LF Brandon Pfaadt P	Los Angeles Dodgers WIN 5.1-4.2 by 0.9 Prediction	Arizona Diamondbacks wins 5-4
9:40 PM	Colorado Rockies @ Seattle Mariners McCade Brown vs Bryce Miller O/U 8 +/- Lineups Tyler Freeman DH Mickey Moniak RF Hunter Goodman C Blaine Crim 1B Jordan Beck LF Ezequiel Tovar SS Brenton Doyle CF Kyle Karros 3B Ryan Ritter 2B McCade Brown P Randy Arozarena LF Cal Raleigh C Julio Rodriguez CF Josh Naylor 1B Jorge Polanco 2B Eugenio Suarez 3B Dominic Canzone DH Victor Robles RF J.P. Crawford SS Bryce Miller P	Seattle Mariners WIN 5.5-4.4 by 1.1 Prediction	Seattle Mariners wins 4-3
9:40 PM	Milwaukee Brewers @ San Diego Padres Bruce Zimmermann vs Randy Vasquez O/U 8 +/- Lineups Christian Yelich DH Jackson Chourio LF Brice Turang 2B William Contreras C Sal Frelick RF Caleb Durbin 3B Jake Bauers 1B Blake Perkins CF Joey Ortiz SS Bruce Zimmermann P Luis Arraez DH Xander Bogaerts SS Gavin Sheets LF Ramon Laureano RF Ryan O'Hearn 1B Jose Iglesias 3B Bryce Johnson CF Freddy Fermin C Mason McCoy 2B Randy Vasquez P	Milwaukee Brewers WIN 4.2-4.2 by 0.0 Prediction	San Diego Padres wins 7-0
9:45 PM	St. Louis Cardinals @ San Francisco Giants Andre Pallante vs Logan Webb O/U 7.5 +/- Lineups Lars Nootbaar LF Ivan Herrera DH Alec Burleson 1B Nolan Arenado 3B Thomas Saggese SS Jose Fermin 2B Jimmy Crooks C Jordan Walker RF Victor Scott CF Andre Pallante P Heliot Ramos LF Rafael Devers 1B Willy Adames SS Matt Chapman 3B Bryce Eldridge DH Jung Hoo Lee CF Patrick Bailey C Christian Koss 2B Drew Gilbert RF Logan Webb P	San Francisco Giants WIN 4.9-3.8 by 1.0 Prediction	St. Louis Cardinals wins 9-8
10:05 PM	Houston Astros @ Athletics Cristian Javier vs Jeffrey Springs O/U 10 +/- Lineups Jose Altuve 2B Carlos Correa 3B Isaac Paredes DH Christian Walker 1B Yainer Diaz C Jake Meyers CF Zach Cole LF Cam Smith RF Mauricio Dubon SS Cristian Javier P Nick Kurtz 1B Shea Langeliers C Tyler Soderstrom LF Brent Rooker DH Jacob Wilson SS Lawrence Butler CF Darell Hernaiz 2B Carlos Cortes RF Brett Harris 3B Jeffrey Springs P	Athletics WIN 4.8-4.7 by 0.1 Prediction	Athletics wins 5-1

Legend/Totals

Correct Picks	7 (46.7%)
Incorrect Picks	8 (53.3%)
Final Margin within 5 Runs	3 (20.0%)
Beat the Spread	10 (66.7%)

MLB Predictions for 9/23/2025

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