MLB Predictions & Baseball Game Simulator - MyGameSim.com

MLB Predictions for 7/21/2025


7/21/2025 MLB Games
Time *ETMatchupPredictionActualResult
6:40 PM Baltimore Orioles @ Cleveland Guardians  
Tomoyuki Sugano vs Tanner Bibee
-143 or 58.8%
+/- Lineups
Cleveland Guardians
WIN 51.0% of sims
  by 0.4
Prediction
Cleveland Guardians wins 10-5

6:40 PM Detroit Tigers @ Pittsburgh Pirates  
Jack Flaherty vs Paul Skenes
-135 or 57.4%
+/- Lineups
Pittsburgh Pirates
WIN 51.9% of sims
  by 0.2
Prediction
Pittsburgh Pirates wins 3-0

6:40 PM San Diego Padres @ Miami Marlins  
Randy Vasquez vs Eury Perez
-142 or 58.7%
+/- Lineups
Miami Marlins
WIN 65.1% of sims
  by 1.3
Prediction
San Diego Padres wins 2-1

6:45 PM Cincinnati Reds @ Washington Nationals  
Brady Singer vs Jake Irvin
-104 or 51.0%
+/- Lineups
Cincinnati Reds
WIN 55.4% of sims
  by 0.9
Prediction
Washington Nationals wins 10-8

6:45 PM Boston Red Sox @ Philadelphia Phillies  
Walker Buehler vs Zack Wheeler
-245 or 71.0%
+/- Lineups
Philadelphia Phillies
WIN 61.8% of sims
  by 1.2
Prediction
Philadelphia Phillies wins 3-2

 
7:07 PM New York Yankees @ Toronto Blue Jays  
Carlos Rodon vs Kevin Gausman
-100 or 50.0%
+/- Lineups
New York Yankees
WIN 55.9% of sims
  by 0.9
Prediction
Toronto Blue Jays wins 4-1

7:10 PM Los Angeles Angels @ New York Mets  
Tyler Anderson vs Kodai Senga
-190 or 65.5%
+/- Lineups
Los Angeles Angels
WIN 50.9% of sims
  by 0.4
Prediction
New York Mets wins 7-5

7:15 PM San Francisco Giants @ Atlanta Braves  
Hayden Birdsong vs Bryce Elder
-134 or 57.3%
+/- Lineups
San Francisco Giants
WIN 53.8% of sims
  by 0.8
Prediction
Atlanta Braves wins 9-5

7:35 PM Chicago White Sox @ Tampa Bay Rays  
Sean Burke vs Shane Baz
-218 or 68.6%
+/- Lineups
Tampa Bay Rays
WIN 55.6% of sims
  by 0.4
Prediction
Chicago White Sox wins 8-3

 
8:05 PM Kansas City Royals @ Chicago Cubs  
Noah Cameron vs Ben Brown
-154 or 60.6%
+/- Lineups
Chicago Cubs
WIN 55.2% of sims
  by 0.2
Prediction
Kansas City Royals wins 12-4

 
8:05 PM Athletics @ Texas Rangers  
Jacob Lopez vs Jack Leiter
-125 or 55.6%
+/- Lineups
Athletics
WIN 59.2% of sims
  by 1.1
Prediction
Texas Rangers wins 7-2

8:40 PM St. Louis Cardinals @ Colorado Rockies  
Michael McGreevy vs Austin Gomber
-148 or 59.7%
+/- Lineups
St. Louis Cardinals
WIN 54.9% of sims
  by 0.7
Prediction
St. Louis Cardinals wins 6-2

9:40 PM Houston Astros @ Arizona Diamondbacks  
Colton Gordon vs Zac Gallen
-142 or 58.7%
+/- Lineups
Arizona Diamondbacks
WIN 71.5% of sims
  by 1.8
Prediction
Houston Astros wins 6-3

9:40 PM Milwaukee Brewers @ Seattle Mariners  
Brandon Woodruff vs George Kirby
-130 or 56.5%
+/- Lineups
Seattle Mariners
WIN 62.5% of sims
  by 1.1
Prediction
Milwaukee Brewers wins 6-0

10:10 PM Minnesota Twins @ Los Angeles Dodgers  
David Festa vs Dustin May
-181 or 64.4%
+/- Lineups
Los Angeles Dodgers
WIN 56.6% of sims
  by 0.4
Prediction
Los Angeles Dodgers wins 5-2

Legend/Totals

Correct Picks 3 (20.0%)
Incorrect Picks 12 (80.0%)
Final Margin within 5 Runs 1 (6.7%)
Beat the Spread 2 (13.3%)

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