MLB Predictions & Baseball Game Simulator - MyGameSim.com

MLB Predictions for 9/16/2025


9/16/2025 MLB Games
Time *ETMatchupPredictionActualResult
1:05 PM Atlanta Braves @ Washington Nationals  
Jose Suarez vs Jake Irvin
-152 or 60.3%
+/- Lineups
Atlanta Braves
WIN 55.1% of sims
  by 0.7
Prediction
Atlanta Braves wins 6-3

6:40 PM Chicago Cubs @ Pittsburgh Pirates  
Cade Horton vs Paul Skenes
-131 or 56.7%
+/- Lineups
Chicago Cubs
WIN 55.3% of sims
  by 0.5
Prediction
Chicago Cubs wins 4-1

 
6:40 PM Cleveland Guardians @ Detroit Tigers  
Joey Cantillo vs Casey Mize
-145 or 59.2%
+/- Lineups
Detroit Tigers
WIN 62.0% of sims
  by 1.0
Prediction
Cleveland Guardians wins 7-5

6:45 PM Athletics @ Boston Red Sox  
Jeffrey Springs vs Connelly Early
-157 or 61.1%
+/- Lineups
Athletics
WIN 50.3% of sims
  by 0.3
Prediction
Athletics wins 2-1

 
 
6:45 PM Atlanta Braves @ Washington Nationals  
Chris Sale vs MacKenzie Gore
-152 or 60.3%
+/- Lineups
Atlanta Braves
WIN 60.0% of sims
  by 1.2
Prediction
Atlanta Braves wins 5-0

7:10 PM San Diego Padres @ New York Mets  
Michael King vs Sean Manaea
-125 or 55.6%
+/- Lineups
New York Mets
WIN 57.4% of sims
  by 0.4
Prediction
New York Mets wins 8-3

 
7:35 PM Toronto Blue Jays @ Tampa Bay Rays  
Jose Berrios vs Ryan Pepiot
-110 or 52.4%
+/- Lineups
Toronto Blue Jays
WIN 52.6% of sims
  by 0.3
Prediction
Toronto Blue Jays wins 6-5

 
 
7:40 PM Baltimore Orioles @ Chicago White Sox  
Dean Kremer vs Shane Smith
-110 or 52.4%
+/- Lineups
Chicago White Sox
WIN 56.8% of sims
  by 0.3
Prediction
Baltimore Orioles wins 8-7

7:40 PM Seattle Mariners @ Kansas City Royals  
Logan Gilbert vs Michael Wacha
-120 or 54.5%
+/- Lineups
Seattle Mariners
WIN 57.0% of sims
  by 1.1
Prediction
Seattle Mariners wins 12-5

 
7:40 PM New York Yankees @ Minnesota Twins  
Cam Schlittler vs Zebby Matthews
-144 or 59.0%
+/- Lineups
New York Yankees
WIN 67.8% of sims
  by 2.2
Prediction
New York Yankees wins 10-9

 
7:40 PM Los Angeles Angels @ Milwaukee Brewers  
Caden Dana vs Freddy Peralta
-277 or 73.5%
+/- Lineups
Milwaukee Brewers
WIN 59.8% of sims
  by 1.0
Prediction
Milwaukee Brewers wins 9-2

7:45 PM Cincinnati Reds @ St. Louis Cardinals  
Andrew Abbott vs Michael McGreevy
-105 or 51.2%
+/- Lineups
Cincinnati Reds
WIN 62.4% of sims
  by 1.5
Prediction
St. Louis Cardinals wins 3-0

8:10 PM Texas Rangers @ Houston Astros  
Merrill Kelly vs AJ Blubaugh
-101 or 50.2%
+/- Lineups
Houston Astros
WIN 59.6% of sims
  by 0.8
Prediction
Houston Astros wins 6-5

 
 
8:40 PM Miami Marlins @ Colorado Rockies  
Eury Perez vs Kyle Freeland
-122 or 55.0%
+/- Lineups
Miami Marlins
WIN 54.8% of sims
  by 0.7
Prediction
Miami Marlins wins 6-5

 
9:40 PM San Francisco Giants @ Arizona Diamondbacks  
Tristan Beck vs Eduardo Rodriguez
-134 or 57.3%
+/- Lineups
Arizona Diamondbacks
WIN 57.1% of sims
  by 0.6
Prediction
Arizona Diamondbacks wins 6-5

 
10:10 PM Philadelphia Phillies @ Los Angeles Dodgers  
Cristopher Sanchez vs Shohei Ohtani
-128 or 56.1%
+/- Lineups
Los Angeles Dodgers
WIN 50.0% of sims
  by 0.3
Prediction
Philadelphia Phillies wins 9-6

 

Legend/Totals

Correct Picks 13 (81.3%)
Incorrect Picks 3 (18.8%)
Final Margin within 5 Runs 5 (31.3%)
Beat the Spread 8 (50.0%)

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