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The MLB Game Simulator uses at-bat-by-at-bat modeling, pitcher data, and player stats to predict outcomes, scores, and performances.

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Yes. Baseball predictions and player stat projections are updated daily to reflect pitching matchups, lineups, and recent performance.

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Accuracy varies by day and matchup. We publish performance summaries so you can track results over time.

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Predictions refresh daily and may update during the day when key injuries or depth chart changes occur.

MLB Predictions for 9/21/2025

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Odds: Line | O/U | Money Line

9/21/2025 MLB Games
Time *ET	Matchup	Prediction	Actual	Result
1:10 PM	Atlanta Braves @ Detroit Tigers Spencer Strider vs Casey Mize -120 or 54.5% +/- Lineups Jurickson Profar LF Matt Olson 1B Ronald Acuna RF Drake Baldwin C Ozzie Albies 2B Ha-Seong Kim SS Marcell Ozuna DH Michael Harris CF Vidal Brujan 3B Spencer Strider P Parker Meadows CF Gleyber Torres 2B Kerry Carpenter DH Riley Greene LF Spencer Torkelson 1B Wenceel Perez RF Dillon Dingler C Zach McKinstry 3B Javier Baez SS Casey Mize P	Atlanta Braves WIN 51.3% of sims by 0.5 Prediction	Atlanta Braves wins 6-2
1:35 PM	Athletics @ Pittsburgh Pirates Mitch Spence vs Mike Burrows -121 or 54.8% +/- Lineups Lawrence Butler CF Brent Rooker DH Nick Kurtz 1B Tyler Soderstrom LF Jacob Wilson SS Carlos Cortes RF Darell Hernaiz 3B Willie MacIver C Max Schuemann 2B Mitch Spence P Oneil Cruz CF Jared Triolo 3B Bryan Reynolds RF Spencer Horwitz 1B Andrew McCutchen DH Nick Gonzales SS Jack Suwinski LF Joey Bart C Nick Yorke 2B Mike Burrows P	Athletics WIN 52.0% of sims by 0.6 Prediction	Pittsburgh Pirates wins 11-0
1:35 PM	New York Yankees @ Baltimore Orioles Cam Schlittler vs Kyle Bradish -112 or 52.8% +/- Lineups Trent Grisham CF Aaron Judge DH Cody Bellinger RF Ben Rice 1B Jasson Dominguez LF Jazz Chisholm 2B Jose Caballero SS Austin Wells C Ryan McMahon 3B Cam Schlittler P Jackson Holliday 2B Dylan Beavers RF Gunnar Henderson SS Ryan Mountcastle DH Samuel Basallo C Jeremiah Jackson 3B Colton Cowser CF Coby Mayo 1B Dylan Carlson LF Kyle Bradish P	New York Yankees WIN 53.8% of sims by 0.6 Prediction	New York Yankees wins 7-1
1:40 PM	Washington Nationals @ New York Mets Jake Irvin vs Clay Holmes -290 or 74.4% +/- Lineups James Wood DH Dylan Crews RF Josh Bell 1B Daylen Lile LF Paul DeJong 2B Jorge Alfaro C Brady House 3B Nasim Nunez SS Jacob Young CF Jake Irvin P Francisco Lindor SS Juan Soto RF Brandon Nimmo LF Pete Alonso 1B Jeff McNeil 2B Mark Vientos DH Brett Baty 3B Luis Torrens C Cedric Mullins CF Clay Holmes P	New York Mets WIN 65.9% of sims by 1.2 Prediction	Washington Nationals wins 3-2
1:40 PM	Chicago Cubs @ Cincinnati Reds Jameson Taillon vs Andrew Abbott -126 or 55.8% +/- Lineups Nico Hoerner 2B Ian Happ LF Seiya Suzuki RF Carson Kelly C Carlos Santana DH Dansby Swanson SS Justin Turner 3B Michael Busch 1B Kevin Alcantara CF Jameson Taillon P TJ Friedl CF Gavin Lux DH Noelvi Marte RF Spencer Steer 1B Will Benson LF Elly De La Cruz SS Ke'Bryan Hayes 3B Jose Trevino C Matt McLain 2B Andrew Abbott P	Cincinnati Reds WIN 54.6% of sims by 0.2 Prediction	Cincinnati Reds wins 1-0
1:40 PM	Atlanta Braves @ Detroit Tigers Spencer Strider vs Casey Mize -120 or 54.5% +/- Lineups Jurickson Profar LF Matt Olson 1B Ronald Acuna RF Drake Baldwin C Ozzie Albies 2B Ha-Seong Kim SS Marcell Ozuna DH Michael Harris CF Vidal Brujan 3B Spencer Strider P Parker Meadows CF Gleyber Torres 2B Kerry Carpenter DH Riley Greene LF Spencer Torkelson 1B Wenceel Perez RF Dillon Dingler C Zach McKinstry 3B Javier Baez SS Casey Mize P	Atlanta Braves WIN 52.3% of sims by 0.4 Prediction \| Simulate
2:10 PM	San Diego Padres @ Chicago White Sox Michael King vs Sean Burke -150 or 60.0% +/- Lineups Fernando Tatis RF Luis Arraez 2B Manny Machado 3B Jackson Merrill CF Ramon Laureano LF Gavin Sheets DH Ryan O'Hearn 1B Jake Cronenworth SS Elias Diaz C Michael King P Chase Meidroth 2B Kyle Teel DH Colson Montgomery SS Miguel Vargas 3B Edgar Quero C Brooks Baldwin CF Lenyn Sosa 1B Will Robertson LF Dominic Fletcher RF Sean Burke P	San Diego Padres WIN 62.6% of sims by 1.5 Prediction	San Diego Padres wins 3-2
2:10 PM	Toronto Blue Jays @ Kansas City Royals Trey Yesavage vs Michael Wacha -105 or 51.2% +/- Lineups George Springer DH Daulton Varsho CF Vladimir Guerrero 1B Addison Barger 3B Davis Schneider LF Nathan Lukes RF Ernie Clement 2B Andres Gimenez SS Tyler Heineman C Trey Yesavage P Mike Yastrzemski LF Bobby Witt SS Vinnie Pasquantino 1B Maikel Garcia 3B Salvador Perez DH Adam Frazier 2B Carter Jensen C Jac Caglianone RF John Rave CF Michael Wacha P	Toronto Blue Jays WIN 63.4% of sims by 1.9 Prediction	Toronto Blue Jays wins 8-5
2:10 PM	Cleveland Guardians @ Minnesota Twins Joey Cantillo vs Simeon Woods Richardson -121 or 54.8% +/- Lineups Steven Kwan LF George Valera DH Jose Ramirez 3B Kyle Manzardo 1B Bo Naylor C Gabriel Arias SS Angel Martinez CF C.J. Kayfus RF Brayan Rocchio 2B Joey Cantillo P Byron Buxton CF Kody Clemens 2B Austin Martin LF Trevor Larnach RF Luke Keaschall DH Edouard Julien 1B Brooks Lee SS Jhonny Pereda C Ryan Fitzgerald 3B Simeon Woods Richardson P	Cleveland Guardians WIN 52.4% of sims by 0.5 Prediction	Minnesota Twins wins 6-2
2:15 PM	Milwaukee Brewers @ St. Louis Cardinals Erick Fedde vs Matthew Liberatore -113 or 53.1% +/- Lineups Jackson Chourio RF Isaac Collins LF Andrew Vaughn 1B Rhys Hoskins DH Caleb Durbin 3B Andruw Monasterio 2B Danny Jansen C Blake Perkins CF Joey Ortiz SS Erick Fedde P Thomas Saggese SS Ivan Herrera DH Alec Burleson 1B Lars Nootbaar LF Jordan Walker RF Nolan Gorman 3B Jose Fermin 2B Jimmy Crooks C Victor Scott CF Matthew Liberatore P	Milwaukee Brewers WIN 58.0% of sims by 1.2 Prediction	St. Louis Cardinals wins 5-1
2:35 PM	Miami Marlins @ Texas Rangers Eury Perez vs Merrill Kelly -125 or 55.6% +/- Lineups Jakob Marsee CF Agustin Ramirez DH Xavier Edwards 2B Liam Hicks 1B Otto Lopez SS Troy Johnston RF Heriberto Hernandez LF Graham Pauley 3B Brian Navarreto C Eury Perez P Joc Pederson DH Wyatt Langford LF Alejandro Osuna RF Rowdy Tellez 1B Josh Jung 3B Cody Freeman 2B Jonah Heim C Ezequiel Duran SS Michael Helman CF Merrill Kelly P	Miami Marlins WIN 60.3% of sims by 1.1 Prediction	Miami Marlins wins 4-2
3:10 PM	Los Angeles Angels @ Colorado Rockies Caden Dana vs Kyle Freeland -112 or 52.8% +/- Lineups Mike Trout DH Taylor Ward LF Jo Adell RF Nolan Schanuel 1B Logan O'Hoppe C Christian Moore 2B Oswald Peraza 3B Denzer Guzman SS Bryce Teodosio CF Caden Dana P Mickey Moniak RF Ezequiel Tovar SS Hunter Goodman DH Blaine Crim 1B Jordan Beck LF Brenton Doyle CF Kyle Karros 3B Braxton Fulford C Ryan Ritter 2B Kyle Freeland P	Colorado Rockies WIN 52.3% of sims by 0.1 Prediction	Colorado Rockies wins 3-1
4:10 PM	Philadelphia Phillies @ Arizona Diamondbacks Ranger Suarez vs Eduardo Rodriguez -110 or 52.4% +/- Lineups Harrison Bader CF Kyle Schwarber DH Bryce Harper 1B J.T. Realmuto C Alec Bohm 3B Nick Castellanos RF Otto Kemp 2B Bryson Stott SS Weston Wilson LF Ranger Suarez P Ketel Marte 2B Geraldo Perdomo SS Corbin Carroll RF Gabriel Moreno C Blaze Alexander 3B Ildemaro Vargas 1B Tim Tawa LF Jordan Lawlar DH Jorge Barrosa CF Eduardo Rodriguez P	Philadelphia Phillies WIN 55.1% of sims by 0.8 Prediction	Arizona Diamondbacks wins 9-2
4:10 PM	San Francisco Giants @ Los Angeles Dodgers Trevor McDonald vs Emmet Sheehan -228 or 69.5% +/- Lineups Heliot Ramos LF Rafael Devers DH Willy Adames SS Matt Chapman 3B Bryce Eldridge 1B Jung Hoo Lee CF Christian Koss 2B Drew Gilbert RF Andrew Knizner C Trevor McDonald P Shohei Ohtani DH Mookie Betts SS Freddie Freeman 1B Max Muncy 3B Andy Pages CF Michael Conforto LF Miguel Rojas 2B Alex Call RF Dalton Rushing C Emmet Sheehan P	Los Angeles Dodgers WIN 67.3% of sims by 1.9 Prediction	San Francisco Giants wins 3-1
7:10 PM	Seattle Mariners @ Houston Astros Logan Gilbert vs Jason Alexander -122 or 55.0% +/- Lineups Randy Arozarena LF Cal Raleigh C Julio Rodriguez CF Josh Naylor 1B Jorge Polanco 2B Eugenio Suarez 3B Dominic Canzone DH Victor Robles RF J.P. Crawford SS Logan Gilbert P Jeremy Pena SS Carlos Correa 3B Isaac Paredes DH Jose Altuve 2B Christian Walker 1B Jesus Sanchez RF Yainer Diaz C Jake Meyers CF Mauricio Dubon LF Jason Alexander P	Seattle Mariners WIN 56.3% of sims by 0.6 Prediction	Seattle Mariners wins 7-3
7:35 PM	Boston Red Sox @ Tampa Bay Rays Connelly Early vs Joe Boyle -110 or 52.4% +/- Lineups Jarren Duran LF Trevor Story SS Alex Bregman 3B Masataka Yoshida RF Romy Gonzalez 2B Nathaniel Lowe 1B Ceddanne Rafaela CF Wilyer Abreu DH Connor Wong C Connelly Early P Chandler Simpson CF Yandy Diaz DH Junior Caminero 3B Brandon Lowe 2B Christopher Morel LF Nick Fortes C Tristan Gray 1B Everson Pereira RF Carson Williams SS Joe Boyle P	Boston Red Sox WIN 51.5% of sims by 0.4 Prediction	Tampa Bay Rays wins 7-3

Legend/Totals

Correct Picks	7 (46.7%)
Incorrect Picks	8 (53.3%)
Final Margin within 5 Runs	3 (20.0%)
Beat the Spread	10 (66.7%)

MLB Predictions for 9/21/2025

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