MLB Predictions for 9/22/2025
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Odds: Line | O/U | Money Line
| 9/22/2025 MLB Games | ||||
|---|---|---|---|---|
| Time *ET | Matchup | Prediction | Actual | Result |
| 7:15 PM |  Washington Nationals @ Atlanta Braves  MacKenzie Gore vs Chris Sale -278 or 73.5%+/- Lineups | Atlanta Braves WIN 69.2% of sims by 1.5Prediction | Atlanta Braves wins 11-5 |  |
| 9:40 PM |  Milwaukee Brewers @ San Diego Padres  Freddy Peralta vs Nick Pivetta -116 or 53.7%+/- Lineups | Milwaukee Brewers WIN 53.3% of sims by 0.5Prediction | San Diego Padres wins 5-4 |  |
| 9:45 PM |  St. Louis Cardinals @ San Francisco Giants  Michael McGreevy vs Justin Verlander -148 or 59.7%+/- Lineups | San Francisco Giants WIN 57.0% of sims by 0.6Prediction | St. Louis Cardinals wins 6-5 |  |
Legend/Totals
Correct Picks  | 1 (33.3%) |
Incorrect Picks  | 2 (66.7%) |
Final Margin within 5 Runs  | 0 (0.0%) |
| Beat the Spread | 1 (33.3%) |
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