NFL Predictions & Game Simulator - MyGameSim.com

NFL Predictions for Week 17

Looking like a big day for Jaxon Smith-Njigba (Seahawks). In this week's simulations, he averaged 154.9 receiving yards per game.
To view all of this week's player projections, you'll need a GameSim+ account.

Odds: Line |  O/U

Week 17 NFL Games
Date/TimeMatchupPredictionActualResult
9/7/2025 1 PM  Miami Dolphins @ Indianapolis Colts 
Spd: -1.5
📊 GOLD
Indianapolis Colts
WIN 22.5-21.3
won 53.21% of sims, average margin of 1.2
Prediction
Projected Stats 		Indianapolis Colts wins 33-8

9/14/2025 4:05 PM  Denver Broncos @ Indianapolis Colts 
Spd: +2.5
📊 GOLD
Indianapolis Colts
WIN 16.1-15.5
won 52.89% of sims, average margin of 0.6
Prediction
Projected Stats 		Indianapolis Colts wins 29-28

 
 
9/21/2025 1 PM  Indianapolis Colts @ Tennessee Titans 
Spd: +4.5
📊 GOLD
Indianapolis Colts
WIN 24.7-12.1
won 83.92% of sims, average margin of 12.6
Prediction
Projected Stats 		Indianapolis Colts wins 41-20

 
9/28/2025 4:05 PM  Indianapolis Colts @ Los Angeles Rams 
Spd: -3.5
📊 GOLD
Los Angeles Rams
WIN 20.9-18.5
won 58.53% of sims, average margin of 2.4
Prediction
Projected Stats 		Los Angeles Rams wins 27-20

 
10/5/2025 1 PM  Las Vegas Raiders @ Indianapolis Colts 
Spd: -6.5
📊 GOLD
Indianapolis Colts
WIN 27.5-15.0
won 81.43% of sims, average margin of 12.5
Prediction
Projected Stats 		Indianapolis Colts wins 40-6

 
10/12/2025 1 PM  Arizona Cardinals @ Indianapolis Colts 
Spd: -6.5
📊 GOLD
Indianapolis Colts
WIN 19.0-15.6
won 59.69% of sims, average margin of 3.4
Prediction
Projected Stats 		Indianapolis Colts wins 31-27

 
 
10/19/2025 4:05 PM  Indianapolis Colts @ Los Angeles Chargers 
Spd: -1.5
📊 GOLD
Los Angeles Chargers
WIN 25.4-20.0
won 66.41% of sims, average margin of 5.4
Prediction
Projected Stats 		Indianapolis Colts wins 38-24

10/26/2025 4:25 PM  Tennessee Titans @ Indianapolis Colts 
Spd: -14.0
📊 GOLD
Indianapolis Colts
WIN 30.9-10.2
won 95.63% of sims, average margin of 20.7
Prediction
Projected Stats 		Indianapolis Colts wins 38-14

 
 
11/2/2025 1 PM  Indianapolis Colts @ Pittsburgh Steelers 
Spd: +3.0
📊 GOLD
Indianapolis Colts
WIN 25.4-18.4
won 71.02% of sims, average margin of 7.0
Prediction
Projected Stats 		Pittsburgh Steelers wins 27-20

11/9/2025 9:30 AM  Atlanta Falcons @ Indianapolis Colts 
Spd: -5.5
📊 GOLD
Indianapolis Colts
WIN 30.7-20.8
won 79.70% of sims, average margin of 9.9
Prediction
Projected Stats 		Indianapolis Colts wins 31-25

 
 
11/23/2025 1 PM  Indianapolis Colts @ Kansas City Chiefs 
Spd: -3.0
📊 GOLD
Indianapolis Colts
WIN 30.1-27.0
won 60.52% of sims, average margin of 3.0
Prediction
Projected Stats 		Kansas City Chiefs wins 23-20

 
11/30/2025 1 PM  Houston Texans @ Indianapolis Colts 
Spd: -4.5
📊 GOLD
Indianapolis Colts
WIN 29.3-22.2
won 72.40% of sims, average margin of 7.1
Prediction
Projected Stats 		Houston Texans wins 20-16

12/7/2025 1 PM  Indianapolis Colts @ Jacksonville Jaguars 
Spd: +1.5
📊 GOLD
Indianapolis Colts
WIN 27.7-22.5
won 67.78% of sims, average margin of 5.2
Prediction
Projected Stats 		Jacksonville Jaguars wins 36-19

12/14/2025 4:25 PM  Indianapolis Colts @ Seattle Seahawks 
Spd: -13.5
📊 GOLD
Seattle Seahawks
WIN 28.0-16.0
won 85.00% of sims, average margin of 12.0
Prediction
Projected Stats 		Seattle Seahawks wins 18-16

 
12/22/2025 8:15 PM  San Francisco 49ers @ Indianapolis Colts 
ML: +235 / -290Spd: +6.0O/U: 46.5
📊 GOLD
Indianapolis Colts
WIN 28.4-22.1
won 68.44% of sims, average margin of 6.4
Prediction
Projected Stats 		San Francisco 49ers wins 48-27

12/28/2025 1 PM  Jacksonville Jaguars @ Indianapolis Colts 
ML: +240 / -298Spd: +6.5O/U: 47.5
📊 GOLD
Indianapolis Colts
WIN 25.3-23.0
won 58.57% of sims, average margin of 2.4
Prediction | Simulate
Projected Stats 		 

 

Legend/Totals

Correct Picks 9 (60.0%)
Incorrect Picks 6 (40.0%)
Final Margin within 7 Pts 6 (40.0%)
Beat the Spread 7 (46.7%)
Feedback