NFL Predictions & Game Simulator - MyGameSim.com

NFL Predictions for Week 10

Looking like a big day for Jaxon Smith-Njigba (Seahawks). In this week's simulations, he averaged 119.6 receiving yards per game.
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Week 10 NFL Games
Date/TimeMatchupPredictionActualResult
9/7/2025 1 PM  Miami Dolphins @ Indianapolis Colts 
by 1.5
Indianapolis Colts
WIN 22.5-21.3
won 53.21% of sims, average margin of 1.2
Prediction
Projected Stats
Indianapolis Colts wins 33-8

9/14/2025 4:05 PM  Denver Broncos @ Indianapolis Colts 
by 2.5
Indianapolis Colts
WIN 16.1-15.5
won 52.89% of sims, average margin of 0.6
Prediction
Projected Stats
Indianapolis Colts wins 29-28

 
 
9/21/2025 1 PM  Indianapolis Colts @ Tennessee Titans 
by 4.5
Indianapolis Colts
WIN 24.7-12.1
won 83.92% of sims, average margin of 12.6
Prediction
Projected Stats
Indianapolis Colts wins 41-20

 
9/28/2025 4:05 PM  Indianapolis Colts @ Los Angeles Rams 
by 3.5
Los Angeles Rams
WIN 20.9-18.5
won 58.53% of sims, average margin of 2.4
Prediction
Projected Stats
Los Angeles Rams wins 27-20

 
10/5/2025 1 PM  Las Vegas Raiders @ Indianapolis Colts 
by 6.5
Indianapolis Colts
WIN 27.5-15.0
won 81.43% of sims, average margin of 12.5
Prediction
Projected Stats
Indianapolis Colts wins 40-6

 
10/12/2025 1 PM  Arizona Cardinals @ Indianapolis Colts 
by 6.5
Indianapolis Colts
WIN 19.0-15.6
won 59.69% of sims, average margin of 3.4
Prediction
Projected Stats
Indianapolis Colts wins 31-27

 
 
10/19/2025 4:05 PM  Indianapolis Colts @ Los Angeles Chargers 
by 1.5
Los Angeles Chargers
WIN 25.4-20.0
won 66.41% of sims, average margin of 5.4
Prediction
Projected Stats
Indianapolis Colts wins 38-24

10/26/2025 4:25 PM  Tennessee Titans @ Indianapolis Colts 
by 14
Indianapolis Colts
WIN 30.9-10.2
won 95.63% of sims, average margin of 20.7
Prediction
Projected Stats
Indianapolis Colts wins 38-14

 
 
11/2/2025 1 PM  Indianapolis Colts @ Pittsburgh Steelers 
by 3
Indianapolis Colts
WIN 25.4-18.4
won 71.02% of sims, average margin of 7.0
Prediction
Projected Stats
Pittsburgh Steelers wins 27-20

11/9/2025 9:30 AM  Atlanta Falcons @ Indianapolis Colts 
by 5.5
Indianapolis Colts
WIN 30.7-20.7
won 80.38% of sims, average margin of 10.0
Prediction | Simulate
Projected Stats
 

 

Legend/Totals

Correct Picks 7 (77.8%)
Incorrect Picks 2 (22.2%)
Final Margin within 7 Pts 4 (44.4%)
Beat the Spread 5 (55.6%)

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