NFL Predictions & Game Simulator - MyGameSim.com

NFL Predictions for Week 12

Look for Patrick Mahomes (Chiefs) to have a big day. In this week's simulations he averaged 320.6 passing yards per game.
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Week 12 NFL Games
Date/TimeMatchupPredictionActualResult
9/7/2025 4:05 PM  San Francisco 49ers @ Seattle Seahawks 
by 1.5
Seattle Seahawks
WIN 22.4-20.1
won 54.87% of sims, average margin of 2.3
Prediction
Projected Stats
San Francisco 49ers wins 17-13

 
9/14/2025 1 PM  San Francisco 49ers @ New Orleans Saints 
by 3
San Francisco 49ers
WIN 19.5-18.0
won 54.33% of sims, average margin of 1.5
Prediction
Projected Stats
San Francisco 49ers wins 26-21

 
9/21/2025 4:25 PM  Arizona Cardinals @ San Francisco 49ers 
by 2.5
Arizona Cardinals
WIN 15.0-12.0
won 59.53% of sims, average margin of 3.1
Prediction
Projected Stats
San Francisco 49ers wins 16-15

 
 
9/28/2025 4:05 PM  Jacksonville Jaguars @ San Francisco 49ers 
by 3.5
San Francisco 49ers
WIN 16.8-15.2
won 55.39% of sims, average margin of 1.6
Prediction
Projected Stats
Jacksonville Jaguars wins 26-21

 
 
10/2/2025 8:15 PM  San Francisco 49ers @ Los Angeles Rams 
by 8.5
Los Angeles Rams
WIN 24.8-15.0
won 74.88% of sims, average margin of 9.8
Prediction
Projected Stats
San Francisco 49ers wins 26-23

10/12/2025 1 PM  San Francisco 49ers @ Tampa Bay Buccaneers 
by 3
Tampa Bay Buccaneers
WIN 26.0-18.9
won 69.90% of sims, average margin of 7.1
Prediction
Projected Stats
Tampa Bay Buccaneers wins 30-19

 
 
10/19/2025 8:20 PM  Atlanta Falcons @ San Francisco 49ers 
by 3
Atlanta Falcons
WIN 22.0-20.4
won 55.12% of sims, average margin of 1.6
Prediction
Projected Stats
San Francisco 49ers wins 20-10

10/26/2025 1 PM  San Francisco 49ers @ Houston Texans 
by 1.5
Houston Texans
WIN 27.7-15.6
won 80.94% of sims, average margin of 12.1
Prediction
Projected Stats
Houston Texans wins 26-15

 
 
11/2/2025 1 PM  San Francisco 49ers @ New York Giants 
by 2.5
New York Giants
WIN 25.0-21.2
won 61.33% of sims, average margin of 3.8
Prediction
Projected Stats
San Francisco 49ers wins 34-24

11/9/2025 4:25 PM  Los Angeles Rams @ San Francisco 49ers 
by 3.5
Los Angeles Rams
WIN 26.3-24.1
won 58.49% of sims, average margin of 2.3
Prediction
Projected Stats
Los Angeles Rams wins 42-26

11/16/2025 4:05 PM  San Francisco 49ers @ Arizona Cardinals 
by 3.5
Arizona Cardinals
WIN 30.9-24.3
won 70.20% of sims, average margin of 6.6
Prediction
Projected Stats
San Francisco 49ers wins 41-22

11/24/2025 8:15 PM  Carolina Panthers @ San Francisco 49ers 
by 7
San Francisco 49ers
WIN 28.1-24.6
won 57.26% of sims, average margin of 3.4
Prediction | Simulate
Projected Stats
 

 

Legend/Totals

Correct Picks 4 (36.4%)
Incorrect Picks 7 (63.6%)
Final Margin within 7 Pts 6 (54.5%)
Beat the Spread 4 (36.4%)

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